Metabotropic glutamate receptor 8

From Self-sufficiency
Jump to: navigation, search
edit
Glutamate receptor, metabotropic 8
Identifiers
SymbolsGRM8; FLJ41058; GLUR8; GPRC1H; MGC126724; MGLUR8; mGlu8
External IDsOMIM601116 MGI1351345 HomoloGene654 IUPHAR: mGlu8 GeneCards: GRM8 Gene
Orthologs
SpeciesHumanMouse
Entrez291814823
EnsemblENSG00000179603ENSMUSG00000024211
UniProtO00222Q05BD6
RefSeq (mRNA)NM_000845NM_008174
RefSeq (protein)NP_000836NP_032200
Location (UCSC)Chr 7:
126.08 - 126.89 Mb
Chr 6:
27.23 - 28.08 Mb
PubMed search[1][2]

Metabotropic glutamate receptor 8 is a protein that in humans is encoded by the GRM8 gene.[1][2]

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternative splice variants of GRM8 have been described but their full-length nature has not been determined.[2]

Ligands

See also

References

Cite error: Invalid <references> tag; parameter "group" is allowed only.

Use <references />, or <references group="..." />

External links

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

pt:Receptor metabotrópico de glutamato 8
  1. Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
  2. 2.0 2.1 "Entrez Gene: GRM8 glutamate receptor, metabotropic 8". 
  3. Thomas NK, Wright RA, Howson PA, Kingston AE, Schoepp DD, Jane DE (2001). "(S)-3,4-DCPG, a potent and selective mGlu8a receptor agonist, activates metabotropic glutamate receptors on primary afferent terminals in the neonatal rat spinal cord". Neuropharmacology. 40 (3): 311–8. doi:10.1016/S0028-3908(00)00169-6. PMID 11166323.