FZD6

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Frizzled homolog 6 (Drosophila)
Identifiers
Symbols	FZD6; Hfz6
External IDs	OMIM: 603409 MGI: 108474 HomoloGene: 2617 IUPHAR: FZD6 GeneCards: FZD6 Gene
Gene Ontology Molecular function • receptor activity • non-G-protein coupled 7TM receptor activity • G-protein coupled receptor activity • Wnt receptor activity Cellular component • integral to plasma membrane • membrane • apical part of cell Biological process • establishment of planar polarity • neural tube closure • G-protein coupled receptor protein signaling pathway • Wnt receptor signaling pathway • multicellular organismal development • inner ear morphogenesis Sources: Amigo / EGO
RNA expression pattern
250px
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8323	14368
Ensembl	ENSG00000164930	ENSMUSG00000022297
UniProt	O60353	Q3UTZ0
RefSeq (mRNA)	NM_003506	NM_008056
RefSeq (protein)	NP_003497	NP_032082
Location (UCSC)	Chr 8: 104.38 - 104.41 Mb	Chr 15: 38.84 - 38.87 Mb
PubMed search	[1]	[2]

Frizzled-6 is a protein that in humans is encoded by the FZD6 gene.

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD6 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and 7 transmembrane domains. However, unlike many other Fz family members, FDZ6 does not contain a C-terminal PDZ domain-binding motif.

Interactions

FZD6 has been shown to interact with Secreted frizzled-related protein 1.

See also

• Frizzled

External links

• "Frizzled Receptors: FZD₆". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

Further reading

• Wang Y, Macke JP, Abella BS; et al. (1996). "A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled". J. Biol. Chem. 271 (8): 4468–76. doi:10.1074/jbc.271.8.4468. PMID 8626800. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Finch PW, He X, Kelley MJ; et al. (1997). "Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action". Proc. Natl. Acad. Sci. U.S.A. 94 (13): 6770–5. doi:10.1073/pnas.94.13.6770. PMC 21233 Freely accessible. PMID 9192640. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bafico A, Gazit A, Pramila T; et al. (1999). "Interaction of frizzled related protein (FRP) with Wnt ligands and the frizzled receptor suggests alternative mechanisms for FRP inhibition of Wnt signaling". J. Biol. Chem. 274 (23): 16180–7. doi:10.1074/jbc.274.23.16180. PMID 10347172. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241 Freely accessible. PMID 12477932. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Omoto S, Hayashi T, Kitahara K; et al. (2004). "Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R)". Ophthalmic Genet. 25 (2): 81–90. doi:10.1080/13816810490514270. PMID 15370539. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 Freely accessible. PMID 15489334. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kimura K, Wakamatsu A, Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129 Freely accessible. PMID 16344560. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sirchia R, Luparello C (2007). "Mid-region parathyroid hormone-related protein (PTHrP) and gene expression of MDA-MB231 breast cancer cells". Biol. Chem. 388 (5): 457–65. doi:10.1515/BC.2007.059. PMID 17516841. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.