FZD6

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Frizzled homolog 6 (Drosophila)
Identifiers
SymbolsFZD6; Hfz6
External IDsOMIM603409 MGI108474 HomoloGene2617 IUPHAR: FZD6 GeneCards: FZD6 Gene
RNA expression pattern
250px
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez832314368
EnsemblENSG00000164930ENSMUSG00000022297
UniProtO60353Q3UTZ0
RefSeq (mRNA)NM_003506NM_008056
RefSeq (protein)NP_003497NP_032082
Location (UCSC)Chr 8:
104.38 - 104.41 Mb
Chr 15:
38.84 - 38.87 Mb
PubMed search[1][2]

Frizzled-6 is a protein that in humans is encoded by the FZD6 gene.[1][2][3]

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD6 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and 7 transmembrane domains. However, unlike many other Fz family members, FDZ6 does not contain a C-terminal PDZ domain-binding motif.[3]

Interactions

FZD6 has been shown to interact with Secreted frizzled-related protein 1.[4]

See also

References

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External links

  • "Frizzled Receptors: FZD6". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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