Somatostatin receptor 1

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Somatostatin receptor 1
Identifiers
SymbolsSSTR1; SRIF-2
External IDsOMIM182451 MGI98327 HomoloGene820 IUPHAR: sst1 GeneCards: SSTR1 Gene
RNA expression pattern
250px
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez675120605
EnsemblENSG00000139874ENSMUSG00000035431
UniProtP30872Q543T0
RefSeq (mRNA)NM_001049XM_984503
RefSeq (protein)NP_001040XP_989597
Location (UCSC)Chr 14:
37.75 - 37.75 Mb
Chr 12:
59.13 - 59.13 Mb
PubMed search[1][2]

Somatostatin receptor type 1 is a protein that in humans is encoded by the SSTR1 gene.[1][2]

Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biological effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. The encoded protein is a member of the superfamily of somatostatin receptors having seven transmembrane segments, and is expressed in highest levels in jejunum and stomach.[2]

See also

References

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Further reading

  • Yamada Y, Post SR, Wang K; et al. (1992). "Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney". Proc. Natl. Acad. Sci. U.S.A. 89 (1): 251–5. doi:10.1073/pnas.89.1.251. PMC 48214Freely accessible. PMID 1346068. 
  • Fujita T, Yamaji Y, Sato M; et al. (1994). "Gene expression of somatostatin receptor subtypes, SSTR1 and SSTR2, in human lung cancer cell lines". Life Sci. 55 (23): 1797–806. doi:10.1016/0024-3205(94)90090-6. PMID 7968260. 
  • Kaupmann K, Bruns C, Hoyer D; et al. (1993). "Distribution and second messenger coupling of four somatostatin receptor subtypes expressed in brain". FEBS Lett. 331 (1-2): 53–9. doi:10.1016/0014-5793(93)80296-7. PMID 8405411. 
  • Le Romancer M, Cherifi Y, Levasseur S; et al. (1996). "Messenger RNA expression of somatostatin receptor subtypes in human and rat gastric mucosae". Life Sci. 58 (13): 1091–8. doi:10.1016/0024-3205(96)00063-X. PMID 8622562. 
  • Fukusumi S, Kitada C, Takekawa S; et al. (1997). "Identification and characterization of a novel human cortistatin-like peptide". Biochem. Biophys. Res. Commun. 232 (1): 157–63. doi:10.1006/bbrc.1997.6252. PMID 9125122. 
  • de Lecea L, Ruiz-Lozano P, Danielson PE; et al. (1997). "Cloning, mRNA expression, and chromosomal mapping of mouse and human preprocortistatin". Genomics. 42 (3): 499–506. doi:10.1006/geno.1997.4763. PMID 9205124. 
  • Jaïs P, Terris B, Ruszniewski P; et al. (1997). "Somatostatin receptor subtype gene expression in human endocrine gastroentero-pancreatic tumours". Eur. J. Clin. Invest. 27 (8): 639–44. doi:10.1046/j.1365-2362.1997.1740719.x. PMID 9279525. 
  • Ferone D, van Hagen PM, van Koetsveld PM; et al. (1999). "In vitro characterization of somatostatin receptors in the human thymus and effects of somatostatin and octreotide on cultured thymic epithelial cells". Endocrinology. 140 (1): 373–80. doi:10.1210/en.140.1.373. PMID 9886848. 
  • Kumar U, Sasi R, Suresh S; et al. (1999). "Subtype-selective expression of the five somatostatin receptors (hSSTR1-5) in human pancreatic islet cells: a quantitative double-label immunohistochemical analysis". Diabetes. 48 (1): 77–85. doi:10.2337/diabetes.48.1.77. PMID 9892225. 
  • Rocheville M, Lange DC, Kumar U; et al. (2000). "Subtypes of the somatostatin receptor assemble as functional homo- and heterodimers". J. Biol. Chem. 275 (11): 7862–9. doi:10.1074/jbc.275.11.7862. PMID 10713101. 
  • Schwärzler A, Kreienkamp HJ, Richter D (2000). "Interaction of the somatostatin receptor subtype 1 with the human homolog of the Shk1 kinase-binding protein from yeast". J. Biol. Chem. 275 (13): 9557–62. doi:10.1074/jbc.275.13.9557. PMID 10734105. 
  • Zatelli MC, Tagliati F, Taylor JE; et al. (2001). "Somatostatin receptor subtypes 2 and 5 differentially affect proliferation in vitro of the human medullary thyroid carcinoma cell line tt". J. Clin. Endocrinol. Metab. 86 (5): 2161–9. doi:10.1210/jc.86.5.2161. PMID 11344221. 
  • Klisovic DD, O'Dorisio MS, Katz SE; et al. (2001). "Somatostatin receptor gene expression in human ocular tissues: RT-PCR and immunohistochemical study". Invest. Ophthalmol. Vis. Sci. 42 (10): 2193–201. PMID 11527930. 
  • Pasquali D, Notaro A, Esposito D; et al. (2002). "[Somatostatin receptor genes expression and effects of octreotide on orbital fibroblasts from Graves' ophthalmopathy]". Minerva Endocrinol. 26 (3): 175–9. PMID 11753241. 
  • Papotti M, Bongiovanni M, Volante M; et al. (2002). "Expression of somatostatin receptor types 1-5 in 81 cases of gastrointestinal and pancreatic endocrine tumors. A correlative immunohistochemical and reverse-transcriptase polymerase chain reaction analysis". Virchows Arch. 440 (5): 461–75. doi:10.1007/s00428-002-0609-x. PMID 12021920. 
  • Zatelli MC, Tagliati F, Piccin D; et al. (2002). "Somatostatin receptor subtype 1-selective activation reduces cell growth and calcitonin secretion in a human medullary thyroid carcinoma cell line". Biochem. Biophys. Res. Commun. 297 (4): 828–34. doi:10.1016/S0006-291X(02)02307-0. PMID 12359227. 
  • Ferone D, Pivonello R, Van Hagen PM; et al. (2002). "Quantitative and functional expression of somatostatin receptor subtypes in human thymocytes". Am. J. Physiol. Endocrinol. Metab. 283 (5): E1056–66. doi:10.1152/ajpendo.00205.2001. PMID 12376335. 
  • Pasquali D, Notaro A, Bonavolonta' G; et al. (2002). "Somatostatin receptor genes are expressed in lymphocytes from retroorbital tissues in Graves' disease". J. Clin. Endocrinol. Metab. 87 (11): 5125–9. doi:10.1210/jc.2002-020790. PMID 12414882. 
  • Dizeyi N, Konrad L, Bjartell A; et al. (2002). "Localization and mRNA expression of somatostatin receptor subtypes in human prostatic tissue and prostate cancer cell lines". Urol. Oncol. 7 (3): 91–8. doi:10.1016/S1078-1439(01)00173-9. PMID 12474541. 

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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  2. 2.0 2.1 "Entrez Gene: SSTR1 somatostatin receptor 1".