Prostaglandin D2 receptor

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Prostaglandin D2 receptor (DP)
Identifiers
SymbolsPTGDR; AS1; ASRT1; DP; MGC49004
External IDsOMIM604687 MGI102966 HomoloGene736 IUPHAR: DP1 GeneCards: PTGDR Gene
RNA expression pattern
250px
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez572919214
EnsemblENSG00000168229ENSMUSG00000071489
UniProtQ13258Q8CCM3
RefSeq (mRNA)NM_000953NM_008962
RefSeq (protein)NP_000944NP_032988
Location (UCSC)Chr 14:
51.8 - 51.81 Mb
Chr 14:
43.77 - 43.78 Mb
PubMed search[1][2]

Prostaglandin D2 receptor (DP1) is a G-protein coupled receptor, encoded by the PTGDR gene, for prostaglandin D2.[1]


Mechanism

DP1 is a G-protein-coupled receptor. Its activity is mainly mediated by G-S proteins that stimulate adenylate cyclase resulting in an elevation of intracellular cAMP and Ca2+.

Function

Knockout studies in mice suggest that the ligand of this receptor, prostaglandin D2 (PGD2), functions as a mast cell-derived mediator to trigger asthmatic responses.[1] It also causes vasodilation

See also

References

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External links

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

de:Prostaglandin-D2-Rezeptor
  1. 1.0 1.1 "Entrez Gene: PTGDR prostaglandin D2 receptor (DP)".