CELSR2

From Self-sufficiency
Jump to: navigation, search
edit
Cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)
Identifiers
SymbolsCELSR2; CDHF10; EGFL2; FLJ34118; FLJ42737; FLJ45143; FLJ45845; Flamingo1; KIAA0279; MEGF3
External IDsOMIM604265 MGI1858235 HomoloGene1078 IUPHAR: CELSR2 GeneCards: CELSR2 Gene
RNA expression pattern
250px
250px
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez195253883
EnsemblENSG00000143126ENSMUSG00000068740
UniProtQ9HCU4Q9R0M0
RefSeq (mRNA)NM_001408NM_001004177
RefSeq (protein)NP_001399NP_001004177
Location (UCSC)Chr 1:
109.59 - 109.62 Mb
Chr 3:
108.52 - 108.54 Mb
PubMed search[1][2]

Cadherin EGF LAG seven-pass G-type receptor 2 is a protein that in humans is encoded by the CELSR2 gene.[1][2]

The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined.[2]

See also

References

Cite error: Invalid <references> tag; parameter "group" is allowed only.

Use <references />, or <references group="..." />

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

  1. Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
  2. 2.0 2.1 "Entrez Gene: CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)".