TAS1R1

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Taste receptor, type 1, member 1
Identifiers
Symbols	TAS1R1; TR1; GPR70; T1R1; gm148
External IDs	OMIM: 606225 MGI: 1927505 HomoloGene: 12888 GeneCards: TAS1R1 Gene
Gene Ontology Molecular function • receptor activity • metabotropic glutamate, GABA-B-like receptor activity • taste receptor activity • protein heterodimerization activity Cellular component • membrane • integral to membrane Biological process • signal transduction • G-protein coupled receptor protein signaling pathway • response to stimulus • sensory perception of umami taste Sources: Amigo / EGO
Orthologs
Species	Human	Mouse
Entrez	80835	110326
Ensembl	ENSG00000173662	ENSMUSG00000028950
UniProt	Q7RTX1	Q3U5H1
RefSeq (mRNA)	NM_138697	NM_031867
RefSeq (protein)	NP_619642	NP_114073
Location (UCSC)	Chr 1: 6.54 - 6.56 Mb	Chr 4: 150.87 - 150.88 Mb
PubMed search	[1]	[2]

Taste receptor type 1 member 1 is a protein that in humans is encoded by the TAS1R1 gene.

The protein encoded by this gene is a G protein-coupled receptor and is a component of the heterodimeric amino acid taste receptor T1R1+3. The T1R1+3 receptor responds to L-amino acids but not to D-enantiomers or other compounds. Most amino acids that are perceived as sweet activate T1R1+3, and this activation is strictly dependent on an intact T1R1+3 heterodimer. Multiple transcript variants encoding several different isoforms have been found for this gene.

See also

• Taste receptor

Further reading

• Chandrashekar J, Hoon MA, Ryba NJ, Zuker CS (2007). "The receptors and cells for mammalian taste". Nature. 444 (7117): 288–94. doi:10.1038/nature05401. PMID 17108952. CS1 maint: Multiple names: authors list (link)
• Hoon MA, Adler E, Lindemeier J; et al. (1999). "Putative mammalian taste receptors: a class of taste-specific GPCRs with distinct topographic selectivity". Cell. 96 (4): 541–51. doi:10.1016/S0092-8674(00)80658-3. PMID 10052456. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Makalowska I, Sood R, Faruque MU; et al. (2002). "Identification of six novel genes by experimental validation of GeneMachine predicted genes". Gene. 284 (1-2): 203–13. doi:10.1016/S0378-1119(01)00897-6. PMID 11891061. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nelson G, Chandrashekar J, Hoon MA; et al. (2002). "An amino-acid taste receptor". Nature. 416 (6877): 199–202. doi:10.1038/nature726. PMID 11894099. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Li X, Staszewski L, Xu H; et al. (2002). "Human receptors for sweet and umami taste". Proc. Natl. Acad. Sci. U.S.A. 99 (7): 4692–6. doi:10.1073/pnas.072090199. PMC 123709 Freely accessible. PMID 11917125. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Liao J, Schultz PG (2003). "Three sweet receptor genes are clustered in human chromosome 1". Mamm. Genome. 14 (5): 291–301. doi:10.1007/s00335-002-2233-0. PMID 12856281. 
• Xu H, Staszewski L, Tang H; et al. (2005). "Different functional roles of T1R subunits in the heteromeric taste receptors". Proc. Natl. Acad. Sci. U.S.A. 101 (39): 14258–63. doi:10.1073/pnas.0404384101. PMC 521102 Freely accessible. PMID 15353592. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gregory SG, Barlow KF, McLay KE; et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sainz E, Cavenagh MM, LopezJimenez ND; et al. (2007). "The G-protein coupling properties of the human sweet and amino acid taste receptors". Dev Neurobiol. 67 (7): 948–59. doi:10.1002/dneu.20403. PMID 17506496. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.