Endothelin receptor type A

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Endothelin receptor type A
External IDsOMIM131243 MGI105923 HomoloGene1478 IUPHAR: ETA GeneCards: EDNRA Gene
RNA expression pattern
More reference expression data
RefSeq (mRNA)NM_001957NM_010332
RefSeq (protein)NP_001948NP_034462
Location (UCSC)Chr 4:
148.62 - 148.69 Mb
Chr 8:
80.56 - 80.62 Mb
PubMed search[1][2]

Endothelin receptor type A, also known as ETA, is a human G protein-coupled receptor.[1]


Endothelin receptor type A has been shown to interact with HDAC7A[2] and HTATIP.[2]

See also


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External links

Further reading

  • Arai H, Nakao K, Hosoda K; et al. (1993). "[Molecular cloning of human endothelin receptors and their expression in vascular endothelial cells and smooth muscle cells]". Jpn. Circ. J. 56 Suppl 5: 1303–7. PMID 1291713. 
  • Hosoda K, Nakao K, Tamura N; et al. (1992). "Organization, structure, chromosomal assignment, and expression of the gene encoding the human endothelin-A receptor". J. Biol. Chem. 267 (26): 18797–804. PMID 1326535. 
  • Hayzer DJ, Rose PM, Lynch JS; et al. (1992). "Cloning and expression of a human endothelin receptor: subtype A". Am. J. Med. Sci. 304 (4): 231–8. doi:10.1097/00000441-199210000-00002. PMID 1415318. 
  • Hosoda K, Nakao K, Hiroshi-Arai; et al. (1991). "Cloning and expression of human endothelin-1 receptor cDNA". FEBS Lett. 287 (1-2): 23–6. doi:10.1016/0014-5793(91)80007-P. PMID 1652463. 
  • Cyr C, Huebner K, Druck T, Kris R (1992). "Cloning and chromosomal localization of a human endothelin ETA receptor". Biochem. Biophys. Res. Commun. 181 (1): 184–90. doi:10.1016/S0006-291X(05)81399-3. PMID 1659806. 
  • Adachi M, Yang YY, Furuichi Y, Miyamoto C (1991). "Cloning and characterization of cDNA encoding human A-type endothelin receptor". Biochem. Biophys. Res. Commun. 180 (3): 1265–72. doi:10.1016/S0006-291X(05)81332-4. PMID 1719979. 
  • Lin HY, Kaji EH, Winkel GK; et al. (1991). "Cloning and functional expression of a vascular smooth muscle endothelin 1 receptor". Proc. Natl. Acad. Sci. U.S.A. 88 (8): 3185–9. doi:10.1073/pnas.88.8.3185. PMC 51410Freely accessible. PMID 1849646. 
  • Takigawa M, Sakurai T, Kasuya Y; et al. (1995). "Molecular identification of guanine-nucleotide-binding regulatory proteins which couple to endothelin receptors". Eur. J. Biochem. 228 (1): 102–8. doi:10.1111/j.1432-1033.1995.tb20236.x. PMID 7882989. 
  • Kobayashi S, Tang R, Wang B; et al. (1994). "Binding and functional properties of endothelin receptor subtypes in the human prostate". Mol. Pharmacol. 45 (2): 306–11. PMID 8114678. 
  • Yang H, Tabuchi H, Furuichi Y, Miyamoto C (1993). "Molecular characterization of the 5'-flanking region of human genomic ETA gene". Biochem. Biophys. Res. Commun. 190 (2): 332–9. doi:10.1006/bbrc.1993.1052. PMID 8427579. 
  • Elshourbagy NA, Korman DR, Wu HL; et al. (1993). "Molecular characterization and regulation of the human endothelin receptors". J. Biol. Chem. 268 (6): 3873–9. PMID 8440682. 
  • Miyamoto Y, Yoshimasa T, Arai H; et al. (1996). "Alternative RNA splicing of the human endothelin-A receptor generates multiple transcripts". Biochem. J. 313 ( Pt 3): 795–801. PMC 1216980Freely accessible. PMID 8611157. 
  • Horstmeyer A, Cramer H, Sauer T; et al. (1996). "Palmitoylation of endothelin receptor A. Differential modulation of signal transduction activity by post-translational modification". J. Biol. Chem. 271 (34): 20811–9. doi:10.1074/jbc.271.34.20811. PMID 8702836. 
  • Freedman NJ, Ament AS, Oppermann M; et al. (1997). "Phosphorylation and desensitization of human endothelin A and B receptors. Evidence for G protein-coupled receptor kinase specificity". J. Biol. Chem. 272 (28): 17734–43. doi:10.1074/jbc.272.28.17734. PMID 9211925. 
  • Bourgeois C, Robert B, Rebourcet R; et al. (1997). "Endothelin-1 and ETA receptor expression in vascular smooth muscle cells from human placenta: a new ETA receptor messenger ribonucleic acid is generated by alternative splicing of exon 3". J. Clin. Endocrinol. Metab. 82 (9): 3116–23. doi:10.1210/jc.82.9.3116. PMID 9284755. 
  • Mao XQ, Gao PS, Roberts MH; et al. (1999). "Variants of endothelin-1 and its receptors in atopic asthma". Biochem. Biophys. Res. Commun. 262 (1): 259–62. doi:10.1006/bbrc.1999.1158. PMID 10448102. 
  • Maggi M, Barni T, Fantoni G; et al. (2000). "Expression and biological effects of endothelin-1 in human gonadotropin-releasing hormone-secreting neurons". J. Clin. Endocrinol. Metab. 85 (4): 1658–65. doi:10.1210/jc.85.4.1658. PMID 10770212. 
  • Shraga-Levine Z, Sokolovsky M (2000). "Functional coupling of G proteins to endothelin receptors is ligand and receptor subtype specific". Cell. Mol. Neurobiol. 20 (3): 305–17. doi:10.1023/A:1007010125316. PMID 10789830. 
  • Lee HJ, Chun M, Kandror KV (2001). "Tip60 and HDAC7 interact with the endothelin receptor a and may be involved in downstream signaling". J. Biol. Chem. 276 (20): 16597–600. doi:10.1074/jbc.C000909200. PMID 11262386. 
  • Paasche JD, Attramadal T, Sandberg C; et al. (2001). "Mechanisms of endothelin receptor subtype-specific targeting to distinct intracellular trafficking pathways". J. Biol. Chem. 276 (36): 34041–50. doi:10.1074/jbc.M103243200. PMID 11382773. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

  1. "Entrez Gene: EDNRA endothelin receptor type A". 
  2. 2.0 2.1 Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.