TAS2R38

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Taste receptor, type 2, member 38
Identifiers
SymbolsTAS2R38; PTC; T2R61
External IDsOMIM607751 MGI2681306 HomoloGene47976 GeneCards: TAS2R38 Gene
Orthologs
SpeciesHumanMouse
Entrez5726387513
EnsemblENSG00000183609ENSMUSG00000058250
UniProtP59533A0PK79
RefSeq (mRNA)NM_176817NM_001001451
RefSeq (protein)NP_789787NP_001001451
Location (UCSC)Chr 7:
141.32 - 141.32 Mb
Chr 6:
40.54 - 40.54 Mb
PubMed search[1][2]

TAS2R38 is a bitter taste receptor[1][2] which facilitates the tasting of phenylthiocarbamide (PTC)[3] and propylthiouracil (PROP),[4] although it does not explain supertasting.[5]. Carriers of the PAV allele experience more bitterness from vegetables (Sandell & Breslin 2006) and consume vegetables less frequently and in lower amounts (Duffy et al 2010).

References

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Further reading

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zh:TAS2R38
  1. Jump up Conte C, Ebeling M, Marcuz A, Nef P, Andres-Barquin PJ (2002). "Identification and characterization of human taste receptor genes belonging to the TAS2R family". Cytogenet. Genome Res. 98 (1): 45–53. doi:10.1159/000068546. PMID 12584440. 
  2. Jump up Drayna D, Coon H, Kim UK, Elsner T, Cromer K, Otterud B, Baird L, Peiffer AP, Leppert M (2003). "Genetic analysis of a complex trait in the Utah Genetic Reference Project: a major locus for PTC taste ability on chromosome 7q and a secondary locus on chromosome 16p". Hum. Genet. 112 (5-6): 567–72. doi:10.1007/s00439-003-0911-y. PMID 12624758. 
  3. Jump up Prodi DA, Drayna D, Forabosco P, Palmas MA, Maestrale GB, Piras D, Pirastu M, Angius A (2004). "Bitter taste study in a sardinian genetic isolate supports the association of phenylthiocarbamide sensitivity to the TAS2R38 bitter receptor gene". Chem. Senses. 29 (8): 697–702. doi:10.1093/chemse/bjh074. PMID 15466815. 
  4. Jump up Duffy VB, Davidson AC, Kidd JR, Kidd KK, Speed WC, Pakstis AJ, Reed DR, Snyder DJ, Bartoshuk LM (2004). "Bitter receptor gene (TAS2R38), 6-n-propylthiouracil (PROP) bitterness and alcohol intake". Alcohol. Clin. Exp. Res. 28 (11): 1629–37. doi:10.1097/01.ALC.0000145789.55183.D4. PMC 1397913Freely accessible. PMID 15547448. 
  5. Jump up Hayes JE, Bartoshuk LM, Kidd JR, Duffy VB (2008). "Supertasting and PROP Bitterness Depends on More Than the TAS2R38 Gene". Chem Senses. 33 (3): 255–65. doi:10.1093/chemse/bjm084. PMID 18209019.