TAS2R38
From Self-sufficiency
| edit |
| Taste receptor, type 2, member 38 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | TAS2R38; PTC; T2R61 | ||||||||||||
| External IDs | OMIM: 607751 MGI: 2681306 HomoloGene: 47976 GeneCards: TAS2R38 Gene | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 5726 | 387513 | |||||||||||
| Ensembl | ENSG00000183609 | ENSMUSG00000058250 | |||||||||||
| UniProt | P59533 | A0PK79 | |||||||||||
| RefSeq (mRNA) | NM_176817 | NM_001001451 | |||||||||||
| RefSeq (protein) | NP_789787 | NP_001001451 | |||||||||||
| Location (UCSC) | Chr 7: 141.32 - 141.32 Mb | Chr 6: 40.54 - 40.54 Mb | |||||||||||
| PubMed search | [1] | [2] | |||||||||||
TAS2R38 is a bitter taste receptor[1][2] which facilitates the tasting of phenylthiocarbamide (PTC)[3] and propylthiouracil (PROP),[4] although it does not explain supertasting.[5]. Carriers of the PAV allele experience more bitterness from vegetables (Sandell & Breslin 2006) and consume vegetables less frequently and in lower amounts (Duffy et al 2010).
References
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- Margolskee RF (2002). "Molecular mechanisms of bitter and sweet taste transduction". J. Biol. Chem. 277 (1): 1–4. doi:10.1074/jbc.R100054200. PMID 11696554.
- Montmayeur JP, Matsunami H (2002). "Receptors for bitter and sweet taste". Curr. Opin. Neurobiol. 12 (4): 366–71. doi:10.1016/S0959-4388(02)00345-8. PMID 12139982.
- Kim UK, Drayna D (2005). "Genetics of individual differences in bitter taste perception: lessons from the PTC gene". Clin. Genet. 67 (4): 275–80. doi:10.1111/j.1399-0004.2004.00361.x. PMID 15733260.
- Anne-Spence M, Falk CT, Neiswanger K; et al. (1984). "Estimating the recombination frequency for the PTC-Kell linkage". Hum. Genet. 67 (2): 183–6. doi:10.1007/BF00272997. PMID 6745938.
- Bufe B, Hofmann T, Krautwurst D; et al. (2002). "The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides". Nat. Genet. 32 (3): 397–401. doi:10.1038/ng1014. PMID 12379855.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241 Freely accessible. PMID 12477932.
- Zhang Y, Hoon MA, Chandrashekar J; et al. (2003). "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways". Cell. 112 (3): 293–301. doi:10.1016/S0092-8674(03)00071-0. PMID 12581520.
- Conte C, Ebeling M, Marcuz A; et al. (2003). "Identification and characterization of human taste receptor genes belonging to the TAS2R family". Cytogenet. Genome Res. 98 (1): 45–53. doi:10.1159/000068546. PMID 12584440.
- Kim UK, Jorgenson E, Coon H; et al. (2003). "Positional cloning of the human quantitative trait locus underlying taste sensitivity to phenylthiocarbamide". Science. 299 (5610): 1221–5. doi:10.1126/science.1080190. PMID 12595690.
- Drayna D, Coon H, Kim UK; et al. (2003). "Genetic analysis of a complex trait in the Utah Genetic Reference Project: a major locus for PTC taste ability on chromosome 7q and a secondary locus on chromosome 16p". Hum. Genet. 112 (5-6): 567–72. doi:10.1007/s00439-003-0911-y. PMID 12624758.
- Scherer SW, Cheung J, MacDonald JR; et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961 Freely accessible. PMID 12690205.
- Wooding S, Kim UK, Bamshad MJ; et al. (2004). "Natural selection and molecular evolution in PTC, a bitter-taste receptor gene". Am. J. Hum. Genet. 74 (4): 637–46. doi:10.1086/383092. PMC 1181941 Freely accessible. PMID 14997422.
- Pronin AN, Tang H, Connor J, Keung W (2005). "Identification of ligands for two human bitter T2R receptors". Chem. Senses. 29 (7): 583–93. doi:10.1093/chemse/bjh064. PMID 15337684.
- Prodi DA, Drayna D, Forabosco P; et al. (2005). "Bitter taste study in a sardinian genetic isolate supports the association of phenylthiocarbamide sensitivity to the TAS2R38 bitter receptor gene". Chem. Senses. 29 (8): 697–702. doi:10.1093/chemse/bjh074. PMID 15466815.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 Freely accessible. PMID 15489334.
- Fischer A, Gilad Y, Man O, Pääbo S (2005). "Evolution of bitter taste receptors in humans and apes". Mol. Biol. Evol. 22 (3): 432–6. doi:10.1093/molbev/msi027. PMID 15496549.
- Go Y, Satta Y, Takenaka O, Takahata N (2006). "Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates". Genetics. 170 (1): 313–26. doi:10.1534/genetics.104.037523. PMC 1449719 Freely accessible. PMID 15744053.
See also
External links
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- ↑ Conte C, Ebeling M, Marcuz A, Nef P, Andres-Barquin PJ (2002). "Identification and characterization of human taste receptor genes belonging to the TAS2R family". Cytogenet. Genome Res. 98 (1): 45–53. doi:10.1159/000068546. PMID 12584440.
- ↑ Drayna D, Coon H, Kim UK, Elsner T, Cromer K, Otterud B, Baird L, Peiffer AP, Leppert M (2003). "Genetic analysis of a complex trait in the Utah Genetic Reference Project: a major locus for PTC taste ability on chromosome 7q and a secondary locus on chromosome 16p". Hum. Genet. 112 (5-6): 567–72. doi:10.1007/s00439-003-0911-y. PMID 12624758.
- ↑ Prodi DA, Drayna D, Forabosco P, Palmas MA, Maestrale GB, Piras D, Pirastu M, Angius A (2004). "Bitter taste study in a sardinian genetic isolate supports the association of phenylthiocarbamide sensitivity to the TAS2R38 bitter receptor gene". Chem. Senses. 29 (8): 697–702. doi:10.1093/chemse/bjh074. PMID 15466815.
- ↑ Duffy VB, Davidson AC, Kidd JR, Kidd KK, Speed WC, Pakstis AJ, Reed DR, Snyder DJ, Bartoshuk LM (2004). "Bitter receptor gene (TAS2R38), 6-n-propylthiouracil (PROP) bitterness and alcohol intake". Alcohol. Clin. Exp. Res. 28 (11): 1629–37. doi:10.1097/01.ALC.0000145789.55183.D4. PMC 1397913 Freely accessible. PMID 15547448.
- ↑ Hayes JE, Bartoshuk LM, Kidd JR, Duffy VB (2008). "Supertasting and PROP Bitterness Depends on More Than the TAS2R38 Gene". Chem Senses. 33 (3): 255–65. doi:10.1093/chemse/bjm084. PMID 18209019.
