TAS2R38

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Taste receptor, type 2, member 38
Identifiers
SymbolsTAS2R38; PTC; T2R61
External IDsOMIM607751 MGI2681306 HomoloGene47976 GeneCards: TAS2R38 Gene
Orthologs
SpeciesHumanMouse
Entrez5726387513
EnsemblENSG00000183609ENSMUSG00000058250
UniProtP59533A0PK79
RefSeq (mRNA)NM_176817NM_001001451
RefSeq (protein)NP_789787NP_001001451
Location (UCSC)Chr 7:
141.32 - 141.32 Mb
Chr 6:
40.54 - 40.54 Mb
PubMed search[1][2]

TAS2R38 is a bitter taste receptor[1][2] which facilitates the tasting of phenylthiocarbamide (PTC)[3] and propylthiouracil (PROP),[4] although it does not explain supertasting.[5]. Carriers of the PAV allele experience more bitterness from vegetables (Sandell & Breslin 2006) and consume vegetables less frequently and in lower amounts (Duffy et al 2010).

References

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Further reading

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External links


zh:TAS2R38
  1. Conte C, Ebeling M, Marcuz A, Nef P, Andres-Barquin PJ (2002). "Identification and characterization of human taste receptor genes belonging to the TAS2R family". Cytogenet. Genome Res. 98 (1): 45–53. doi:10.1159/000068546. PMID 12584440. 
  2. Drayna D, Coon H, Kim UK, Elsner T, Cromer K, Otterud B, Baird L, Peiffer AP, Leppert M (2003). "Genetic analysis of a complex trait in the Utah Genetic Reference Project: a major locus for PTC taste ability on chromosome 7q and a secondary locus on chromosome 16p". Hum. Genet. 112 (5-6): 567–72. doi:10.1007/s00439-003-0911-y. PMID 12624758. 
  3. Prodi DA, Drayna D, Forabosco P, Palmas MA, Maestrale GB, Piras D, Pirastu M, Angius A (2004). "Bitter taste study in a sardinian genetic isolate supports the association of phenylthiocarbamide sensitivity to the TAS2R38 bitter receptor gene". Chem. Senses. 29 (8): 697–702. doi:10.1093/chemse/bjh074. PMID 15466815. 
  4. Duffy VB, Davidson AC, Kidd JR, Kidd KK, Speed WC, Pakstis AJ, Reed DR, Snyder DJ, Bartoshuk LM (2004). "Bitter receptor gene (TAS2R38), 6-n-propylthiouracil (PROP) bitterness and alcohol intake". Alcohol. Clin. Exp. Res. 28 (11): 1629–37. doi:10.1097/01.ALC.0000145789.55183.D4. PMC 1397913Freely accessible. PMID 15547448. 
  5. Hayes JE, Bartoshuk LM, Kidd JR, Duffy VB (2008). "Supertasting and PROP Bitterness Depends on More Than the TAS2R38 Gene". Chem Senses. 33 (3): 255–65. doi:10.1093/chemse/bjm084. PMID 18209019.