Somatostatin receptor 3

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Somatostatin receptor 3
Identifiers
SymbolsSSTR3;
External IDsOMIM182453 MGI98329 HomoloGene20285 IUPHAR: sst3 GeneCards: SSTR3 Gene
RNA expression pattern
250px
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez675320607
EnsemblENSG00000183473ENSMUSG00000044933
UniProtP32745Q0VB04
RefSeq (mRNA)NM_001051NM_009218
RefSeq (protein)NP_001042NP_033244
Location (UCSC)Chr 22:
35.93 - 35.94 Mb
Chr 15:
78.36 - 78.37 Mb
PubMed search[1][2]

Somatostatin receptor type 3 is a protein that in humans is encoded by the SSTR3 gene.[1][2]

Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biological effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR3 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in brain and pancreatic islets. SSTR3 is functionally coupled to adenylyl cyclase.[2]

See also

References

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Further reading

  • Yamada Y, Reisine T, Law SF; et al. (1993). "Somatostatin receptors, an expanding gene family: cloning and functional characterization of human SSTR3, a protein coupled to adenylyl cyclase". Mol. Endocrinol. 6 (12): 2136–42. doi:10.1210/me.6.12.2136. PMID 1337145. 
  • Yamada Y, Post SR, Wang K; et al. (1992). "Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney". Proc. Natl. Acad. Sci. U.S.A. 89 (1): 251–5. doi:10.1073/pnas.89.1.251. PMC 48214Freely accessible. PMID 1346068. 
  • Corness JD, Demchyshyn LL, Seeman P; et al. (1993). "A human somatostatin receptor (SSTR3), located on chromosome 22, displays preferential affinity for somatostatin-14 like peptides". FEBS Lett. 321 (2-3): 279–84. doi:10.1016/0014-5793(93)80124-D. PMID 8097479. 
  • Law SF, Zaina S, Sweet R; et al. (1994). "Gi alpha 1 selectively couples somatostatin receptor subtype 3 to adenylyl cyclase: identification of the functional domains of this alpha subunit necessary for mediating the inhibition by somatostatin of cAMP formation". Mol. Pharmacol. 45 (4): 587–90. PMID 8183236. 
  • Kaupmann K, Bruns C, Hoyer D; et al. (1993). "Distribution and second messenger coupling of four somatostatin receptor subtypes expressed in brain". FEBS Lett. 331 (1-2): 53–9. doi:10.1016/0014-5793(93)80296-7. PMID 8405411. 
  • Sharma K, Patel YC, Srikant CB (1997). "Subtype-selective induction of wild-type p53 and apoptosis, but not cell cycle arrest, by human somatostatin receptor 3". Mol. Endocrinol. 10 (12): 1688–96. doi:10.1210/me.10.12.1688. PMID 8961277. 
  • Fukusumi S, Kitada C, Takekawa S; et al. (1997). "Identification and characterization of a novel human cortistatin-like peptide". Biochem. Biophys. Res. Commun. 232 (1): 157–63. doi:10.1006/bbrc.1997.6252. PMID 9125122. 
  • Ain KB, Taylor KD, Tofiq S, Venkataraman G (1997). "Somatostatin receptor subtype expression in human thyroid and thyroid carcinoma cell lines". J. Clin. Endocrinol. Metab. 82 (6): 1857–62. doi:10.1210/jc.82.6.1857. PMID 9177396. 
  • de Lecea L, Ruiz-Lozano P, Danielson PE; et al. (1997). "Cloning, mRNA expression, and chromosomal mapping of mouse and human preprocortistatin". Genomics. 42 (3): 499–506. doi:10.1006/geno.1997.4763. PMID 9205124. 
  • Roth A, Kreienkamp HJ, Meyerhof W, Richter D (1997). "Phosphorylation of four amino acid residues in the carboxyl terminus of the rat somatostatin receptor subtype 3 is crucial for its desensitization and internalization". J. Biol. Chem. 272 (38): 23769–74. doi:10.1074/jbc.272.38.23769. PMID 9295322. 
  • Dunham I, Shimizu N, Roe BA; et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208. 
  • Zatelli MC, Tagliati F, Taylor JE; et al. (2001). "Somatostatin receptor subtypes 2 and 5 differentially affect proliferation in vitro of the human medullary thyroid carcinoma cell line tt". J. Clin. Endocrinol. Metab. 86 (5): 2161–9. doi:10.1210/jc.86.5.2161. PMID 11344221. 
  • Talme T, Ivanoff J, Hägglund M; et al. (2001). "Somatostatin receptor (SSTR) expression and function in normal and leukaemic T-cells. Evidence for selective effects on adhesion to extracellular matrix components via SSTR2 and/or 3". Clin. Exp. Immunol. 125 (1): 71–9. doi:10.1046/j.1365-2249.2001.01577.x. PMC 1906108Freely accessible. PMID 11472428. 
  • Pasquali D, Notaro A, Esposito D; et al. (2002). "[Somatostatin receptor genes expression and effects of octreotide on orbital fibroblasts from Graves' ophthalmopathy]". Minerva Endocrinol. 26 (3): 175–9. PMID 11753241. 
  • Papotti M, Bongiovanni M, Volante M; et al. (2002). "Expression of somatostatin receptor types 1-5 in 81 cases of gastrointestinal and pancreatic endocrine tumors. A correlative immunohistochemical and reverse-transcriptase polymerase chain reaction analysis". Virchows Arch. 440 (5): 461–75. doi:10.1007/s00428-002-0609-x. PMID 12021920. 
  • Ferone D, Pivonello R, Van Hagen PM; et al. (2002). "Quantitative and functional expression of somatostatin receptor subtypes in human thymocytes". Am. J. Physiol. Endocrinol. Metab. 283 (5): E1056–66. doi:10.1152/ajpendo.00205.2001. PMID 12376335. 
  • Pasquali D, Notaro A, Bonavolonta' G; et al. (2002). "Somatostatin receptor genes are expressed in lymphocytes from retroorbital tissues in Graves' disease". J. Clin. Endocrinol. Metab. 87 (11): 5125–9. doi:10.1210/jc.2002-020790. PMID 12414882. 
  • Dizeyi N, Konrad L, Bjartell A; et al. (2002). "Localization and mRNA expression of somatostatin receptor subtypes in human prostatic tissue and prostate cancer cell lines". Urol. Oncol. 7 (3): 91–8. doi:10.1016/S1078-1439(01)00173-9. PMID 12474541. 
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241Freely accessible. PMID 12477932. 

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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  2. 2.0 2.1 "Entrez Gene: SSTR3 somatostatin receptor 3".