Neuromedin U receptor

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neuromedin U receptor 1
Identifiers
Symbol NMUR1
Alt. symbols GPR66
Entrez 10316
HUGO 4518
OMIM 604153
RefSeq NM_006056
UniProt Q9HB89
Other data
Locus Chr. 2 q37.1
neuromedin U receptor 2
Identifiers
Symbol NMUR2
Alt. symbols NMU2R
Entrez 56923
HUGO 16454
OMIM 605108
RefSeq NM_020167
UniProt Q9GZQ4
Other data
Locus Chr. 5 q33.1

The neuromedin U receptors are two G-protein coupled receptors which bind the neuropeptide hormones neuromedin U and neuromedin S.[1] There are two subtypes of the neuromedin U receptor, each encoded by a separate gene (NMUR1, NMUR2).

Selective Ligands

Neuromedin U is an agonist at both the NMU1 and NMU2 subtypes, while neuromedin S is selective for NMU2, and is a more potent agonist at this subtype than neuromedin U.[2][3] Several other peptide and non-peptide ligands are also available for the NMU receptors.

Agonists

Non-selective
NMU2 selective

Antagonists

NMU2 selective

References

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External links

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  5. Kajino M, Hinuma S, Tarui N, Yamashita T, Nakayama Y. Receptor regulators. European Patent EP 1559428 A1. Published 03.08.2005
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