GPRC6A
From Self-sufficiency
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| G protein-coupled receptor, family C, group 6, member A | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | GPRC6A; GPCR; bA86F4.3 | ||||||||||||
| External IDs | MGI: 2429498 HomoloGene: 17529 IUPHAR: GPRC6 GeneCards: GPRC6A Gene | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 222545 | 210198 | |||||||||||
| Ensembl | ENSG00000173612 | ENSMUSG00000019905 | |||||||||||
| UniProt | Q5T6X5 | Q8K4Z6 | |||||||||||
| RefSeq (mRNA) | NM_148963 | NM_153071 | |||||||||||
| RefSeq (protein) | NP_683766 | NP_694711 | |||||||||||
| Location (UCSC) | Chr 6: 117.22 - 117.26 Mb | Chr 10: 51.3 - 51.32 Mb | |||||||||||
| PubMed search | [1] | [2] | |||||||||||
G-protein coupled receptor family C group 6 member A is a protein that in humans is encoded by the GPRC6A gene.[1] This receptor functions as a sensor of L-amino acids.[2]
References
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<references />, or <references group="..." />Further reading
- Harrington JJ, Sherf B, Rundlett S; et al. (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression". Nat. Biotechnol. 19 (5): 440–5. doi:10.1038/88107. PMID 11329013.
- Takeda S, Kadowaki S, Haga T; et al. (2002). "Identification of G protein-coupled receptor genes from the human genome sequence". FEBS Lett. 520 (1-3): 97–101. doi:10.1016/S0014-5793(02)02775-8. PMID 12044878.
- Mungall AJ, Palmer SA, Sims SK; et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
- Wellendorph P, Bräuner-Osborne H (2004). "Molecular cloning, expression, and sequence analysis of GPRC6A, a novel family C G-protein-coupled receptor". Gene. 335: 37–46. doi:10.1016/j.gene.2004.03.003. PMID 15194188.
- Wellendorph P, Hansen KB, Balsgaard A; et al. (2005). "Deorphanization of GPRC6A: a promiscuous L-alpha-amino acid receptor with preference for basic amino acids". Mol. Pharmacol. 67 (3): 589–97. doi:10.1124/mol.104.007559. PMID 15576628.
- Pi M, Faber P, Ekema G; et al. (2006). "Identification of a novel extracellular cation-sensing G-protein-coupled receptor". J. Biol. Chem. 280 (48): 40201–9. doi:10.1074/jbc.M505186200. PMC 1435382 Freely accessible. PMID 16199532.
External links
- "Calcium-Sensing Receptors: GPRC6". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
- MeSH GPRC6A+protein,+human
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- ↑ "Entrez Gene: GPRC6A G protein-coupled receptor, family C, group 6, member A".
- ↑ Wellendorph P, Hansen KB, Balsgaard A, Greenwood JR, Egebjerg J, Bräuner-Osborne H (2005). "Deorphanization of GPRC6A: a promiscuous L-alpha-amino acid receptor with preference for basic amino acids". Mol. Pharmacol. 67 (3): 589–97. doi:10.1124/mol.104.007559. PMID 15576628.
