G protein-coupled bile acid receptor

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G protein-coupled bile acid receptor 1
SymbolsGPBAR1; GPCR; BG37; GPCR19; GPR131; M-BAR; MGC40597; TGR5
External IDsOMIM610147 MGI2653863 HomoloGene18125 IUPHAR: GPBA GeneCards: GPBAR1 Gene
RNA expression pattern
More reference expression data
RefSeq (mRNA)NM_001077191NM_174985
RefSeq (protein)NP_001070659NP_778150
Location (UCSC)Chr 2:
218.83 - 218.84 Mb
Chr 1:
74.21 - 74.21 Mb
PubMed search[1][2]

The G protein-coupled bile acid receptor is a G-protein coupled receptor which binds bile acids.[1] One effect of this receptor is to activate deiodinases which convert the prohormone thyroxine (T4) to the active hormone triiodothyronine (T3). T3 in turn activates the thyroid hormone receptor which increases metabolic rate.[2][3]

This gene encodes a member of the G protein-coupled receptor (GPCR) superfamily. This enzyme functions as a cell surface receptor for bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway, and internalization of the receptor. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids. Alternative splicing results in multiple transcript variants encoding the same protein.[4]


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Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.
  1. Kawamata Y, Fujii R, Hosoya M, Harada M, Yoshida H, Miwa M, Fukusumi S, Habata Y, Itoh T, Shintani Y, Hinuma S, Fujisawa Y, Fujino M (2003). "A G protein-coupled receptor responsive to bile acids". J. Biol. Chem. 278 (11): 9435–40. doi:10.1074/jbc.M209706200. PMID 12524422. 
  2. Watanabe M, Houten SM, Mataki C, Christoffolete MA, Kim BW, Sato H, Messaddeq N, Harney JW, Ezaki O, Kodama T, Schoonjans K, Bianco AC, Auwerx J (2006). "Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation". Nature. 439 (7075): 484–9. doi:10.1038/nature04330. PMID 16400329. 
  3. Baxter JD, Webb P (2006). "Metabolism: bile acids heat things up". Nature. 439 (7075): 402–3. doi:10.1038/439402a. PMID 16437098. 
  4. "Entrez Gene: GPBAR1 G protein-coupled bile acid receptor 1".