Free fatty acid receptor 1

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Free fatty acid receptor 1
Identifiers
SymbolsFFAR1; FFA1R; GPR40
External IDsOMIM: 603820 MGI: 2684079 HomoloGene: 3876 IUPHAR: FFA1 GeneCards: FFAR1 Gene
Orthologs
SpeciesHumanMouse
Entrez2864233081
EnsemblENSG00000126266ENSMUSG00000044453
UniProtO14842Q76JU9
RefSeq (mRNA)NM_005303NM_194057
RefSeq (protein)NP_005294NP_918946
Location (UCSC)Chr 19:
40.53 - 40.54 Mb		Chr 7:
30.57 - 30.57 Mb
PubMed search[1][2]

Free fatty acid receptor 1, (FFA1) is a G-protein coupled receptor encoded by the human gene FFAR1.[1] It is strongly expressed in the cells of the pancreas, but also, to a lesser extent, the uterus and brain[2].


See also

References

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External links

Further reading

  • Brown AJ, Jupe S, Briscoe CP (2005). "A family of fatty acid binding receptors". DNA Cell Biol. 24 (1): 54–61. doi:10.1089/dna.2005.24.54. PMID 15684720. 
  • Sawzdargo M, George SR, Nguyen T; et al. (1997). "A cluster of four novel human G protein-coupled receptor genes occurring in close proximity to CD22 gene on chromosome 19q13.1". Biochem. Biophys. Res. Commun. 239 (2): 543–7. doi:10.1006/bbrc.1997.7513. PMID 9344866. 
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241 Freely accessible. PMID 12477932. 
  • Briscoe CP, Tadayyon M, Andrews JL; et al. (2003). "The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids". J. Biol. Chem. 278 (13): 11303–11. doi:10.1074/jbc.M211495200. PMID 12496284. 
  • Kotarsky K, Nilsson NE, Flodgren E; et al. (2003). "A human cell surface receptor activated by free fatty acids and thiazolidinedione drugs". Biochem. Biophys. Res. Commun. 301 (2): 406–10. doi:10.1016/S0006-291X(02)03064-4. PMID 12565875. 
  • Itoh Y, Kawamata Y, Harada M; et al. (2003). "Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40". Nature. 422 (6928): 173–6. doi:10.1038/nature01478. PMID 12629551. 
  • Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 Freely accessible. PMID 15489334. 
  • Hardy S, St-Onge GG, Joly E; et al. (2005). "Oleate promotes the proliferation of breast cancer cells via the G protein-coupled receptor GPR40". J. Biol. Chem. 280 (14): 13285–91. doi:10.1074/jbc.M410922200. PMID 15695516. 
  • Ogawa T, Hirose H, Miyashita K; et al. (2005). "GPR40 gene Arg211His polymorphism may contribute to the variation of insulin secretory capacity in Japanese men". Metab. Clin. Exp. 54 (3): 296–9. doi:10.1016/j.metabol.2004.09.008. PMID 15736105. 
  • Tomita T, Masuzaki H, Noguchi M; et al. (2006). "GPR40 gene expression in human pancreas and insulinoma". Biochem. Biophys. Res. Commun. 338 (4): 1788–90. doi:10.1016/j.bbrc.2005.10.161. PMID 16289108. 
  • Tomita T, Masuzaki H, Iwakura H; et al. (2006). "Expression of the gene for a membrane-bound fatty acid receptor in the pancreas and islet cell tumours in humans: evidence for GPR40 expression in pancreatic beta cells and implications for insulin secretion". Diabetologia. 49 (5): 962–8. doi:10.1007/s00125-006-0193-8. PMID 16525841. 
  • Stoddart LA, Brown AJ, Milligan G (2007). "Uncovering the pharmacology of the G protein-coupled receptor GPR40: high apparent constitutive activity in guanosine 5'-O-(3-[35S]thio)triphosphate binding studies reflects binding of an endogenous agonist". Mol. Pharmacol. 71 (4): 994–1005. doi:10.1124/mol.106.031534. PMID 17200419. 
  • Bartoov-Shifman R, Ridner G, Bahar K; et al. (2007). "Regulation of the gene encoding GPR40, a fatty acid receptor expressed selectively in pancreatic beta cells". J. Biol. Chem. 282 (32): 23561–71. doi:10.1074/jbc.M702115200. PMID 17525159. 
  • Sum CS, Tikhonova IG, Neumann S; et al. (2007). "Identification of residues important for agonist recognition and activation in GPR40". J. Biol. Chem. 282 (40): 29248–55. doi:10.1074/jbc.M705077200. PMID 17699519. 
40x30px This transmembrane receptor-related article is a stub. You can help ssf by expanding it.
Class A: Rhodopsin like
α1 (A, B, D) · α2 (A, B, C) · β1 · β2 · β3
Adenosine (A1, A2A, A2B, A3) · P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
(all but 5-HT3) 5-HT1 (A, B, D, E, F) · 5-HT2 (A, B, C) · 5-HT (4, 5A, 6, 7)
Other
Acetylcholine (M1, M2, M3, M4, M5) · Dopamine (D1, D2, D3, D4, D5) · Histamine (H1, H2, H3, H4) · Melatonin (1A, 1B, 1C) · TAAR (1, 2, 3, 5, 6, 8, 9)
Metabolites and
signaling molecules
CysLT (1, 2) · LTB4 (1, 2) · FPRL1 · OXE · Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) · Prostacyclin · Thromboxane
Other
Bile acid · Cannabinoid (CB1, CB2, GPR (18, 55, 119)) · EBI2 · Estrogen · Free fatty acid (1, 2, 3, 4) · Lactate  · Lysophosphatidic acid (1, 2, 3, 4, 5, 6)  · Lysophospholipid (1, 2, 3, 4, 5, 6, 7, 8) · Niacin (1, 2) · Oxoglutarate · PAF · Sphingosine-1-phosphate (1, 2, 3, 4, 5) · Succinate
Peptide
B/W (1, 2) · FF (1, 2) · S · Y (1, 2, 4, 5) · Neuromedin (B, U (1, 2)) · Neurotensin (1, 2)
Other
Miscellaneous
GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Other
Class B: Secretin like
GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Other
Class C: Metabotropic
glutamate / pheromone
TAS1R (1, 2, 3) · TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Other
Class F:
Frizzled / Smoothened
Frizzled
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Smoothened
  1. ↑ "Entrez Gene: FFAR1 free fatty acid receptor 1". 
  2. ↑ "UniGene: EST profile FFAR1 free fatty acid receptor 1". 
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