F2RL1

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Coagulation factor II (thrombin) receptor-like 1
Identifiers
SymbolsF2RL1; GPR11; PAR2
External IDsOMIM600933 MGI101910 HomoloGene21087 IUPHAR: PAR2 GeneCards: F2RL1 Gene
RNA expression pattern
250px
250px
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez215014063
EnsemblENSG00000164251ENSMUSG00000021678
UniProtP55085Q3TU81
RefSeq (mRNA)NM_005242NM_007974
RefSeq (protein)NP_005233NP_032000
Location (UCSC)Chr 5:
76.15 - 76.17 Mb
Chr 13:
96.61 - 96.63 Mb
PubMed search[1][2]

Protease activated receptor 2 (PAR2) or Coagulation factor II (thrombin) receptor-like 1, is a protein encoded by the F2RL1 gene in humans.

PAR2 is a member of the large family of 7-transmembrane receptors that couple to guanosine-nucleotide-binding proteins. PAR2 is also a member of the protease-activated receptor family. It is activated by trypsin, but not by thrombin. It is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. Additionally, these receptors can be activated by exogenous proteases, such as house dust mite protein Der P9.[1] These receptors can also be activated non-protealytically, by exogenous peptide sequences that mimic the final amino acids of the tethered ligand.[2] Recently, potent and selective small molecule agonists for these receptors have also been discovered but are not currently widely available.[3] The F2RL1 gene contains two exons and is widely expressed in human tissues. The predicted protein sequence is 83% identical to the mouse receptor sequence.[4]

See also

References

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External links

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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