Relaxin/insulin-like family peptide receptor 4

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Relaxin/insulin-like family peptide receptor 4
Identifiers
Symbols	RXFP4; GPCR142; GPR100; MGC126556; MGC126558; RLN3R2
External IDs	OMIM: 609043 MGI: 2182926 HomoloGene: 18775 IUPHAR: RXFP4 GeneCards: RXFP4 Gene
Gene Ontology Molecular function • rhodopsin-like receptor activity • receptor activity • angiotensin type II receptor activity Cellular component • membrane • integral to membrane Biological process • signal transduction • G-protein coupled receptor protein signaling pathway Sources: Amigo / EGO
Orthologs
Species	Human	Mouse
Entrez	339403	242093
Ensembl	ENSG00000173080	ENSMUSG00000049741
UniProt	Q8TDU9	Q3B805
RefSeq (mRNA)	NM_181885	NM_181817
RefSeq (protein)	NP_871001	NP_861538
Location (UCSC)	Chr 1: 154.18 - 154.18 Mb	Chr 3: 88.74 - 88.74 Mb
PubMed search	[1]	[2]

Relaxin/insulin-like family peptide receptor 4, also known as RXFP4, is a human G-protein coupled receptor.

GPR100 is a member of the rhodopsin family of G protein-coupled receptors (GPRs) (Fredriksson et al., 2003).[supplied by OMIM]

See also

• Relaxin receptor

External links

• "Relaxin Family Peptide Receptors: RXFP4". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

Further reading

• Bathgate RA, Ivell R, Sanborn BM; et al. (2005). "Receptors for relaxin family peptides". Ann. N. Y. Acad. Sci. 1041: 61–76. doi:10.1196/annals.1282.010. PMID 15956688. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bathgate RA, Ivell R, Sanborn BM; et al. (2006). "International Union of Pharmacology LVII: recommendations for the nomenclature of receptors for relaxin family peptides". Pharmacol. Rev. 58 (1): 7–31. doi:10.1124/pr.58.1.9. PMID 16507880. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Takeda S, Kadowaki S, Haga T; et al. (2002). "Identification of G protein-coupled receptor genes from the human genome sequence". FEBS Lett. 520 (1-3): 97–101. doi:10.1016/S0014-5793(02)02775-8. PMID 12044878. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241 Freely accessible. PMID 12477932. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Liu C, Chen J, Sutton S; et al. (2004). "Identification of relaxin-3/INSL7 as a ligand for GPCR142". J. Biol. Chem. 278 (50): 50765–70. doi:10.1074/jbc.M308996200. PMID 14522967. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Boels K, Schaller HC (2004). "Identification and characterisation of GPR100 as a novel human G-protein-coupled bradykinin receptor". Br. J. Pharmacol. 140 (5): 932–8. doi:10.1038/sj.bjp.0705521. PMC 1574110 Freely accessible. PMID 14530218. 
• Fredriksson R, Höglund PJ, Gloriam DE; et al. (2003). "Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives". FEBS Lett. 554 (3): 381–8. doi:10.1016/S0014-5793(03)01196-7. PMID 14623098. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Liu C, Chen J, Kuei C; et al. (2005). "Relaxin-3/insulin-like peptide 5 chimeric peptide, a selective ligand for G protein-coupled receptor (GPCR)135 and GPCR142 over leucine-rich repeat-containing G protein-coupled receptor 7". Mol. Pharmacol. 67 (1): 231–40. doi:10.1124/mol.104.006700. PMID 15465925. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 Freely accessible. PMID 15489334. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Liu C, Kuei C, Sutton S; et al. (2005). "INSL5 is a high affinity specific agonist for GPCR142 (GPR100)". J. Biol. Chem. 280 (1): 292–300. doi:10.1074/jbc.M409916200. PMID 15525639. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gregory SG, Barlow KF, McLay KE; et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.