Thyrotropin receptor

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Thyroid-stimulating hormone receptor
Identifiers
SymbolsTSHR; LGR3; MGC75129; hTSHR-I
External IDsOMIM603372 MGI98849 HomoloGene315 IUPHAR: TSH GeneCards: TSHR Gene
RNA expression pattern
250px
250px
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More reference expression data
Orthologs
SpeciesHumanMouse
Entrez725322095
EnsemblENSG00000165409ENSMUSG00000020963
UniProtP16473Q562E4
RefSeq (mRNA)NM_000369NM_011648
RefSeq (protein)NP_000360NP_035778
Location (UCSC)Chr 14:
80.49 - 80.68 Mb
Chr 12:
91.81 - 91.95 Mb
PubMed search[1][2]

The thyrotropin receptor (or TSH receptor) is a receptor (and associated protein) that responds to thyroid-stimulating hormone (also known as "thyrotropin", and stimulates the production of thyroxine (T4) and triiodothyronine (T3). The TSH receptor is a member of the G protein-coupled receptor superfamily of integral membrane proteins[1] and is coupled to the Gs protein.[2]

It is primarily found on the surface of the thyroid epithelial cells.

See also

References

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Further reading

  • Führer D, Wonerow P, Willgerodt H, Paschke R (1998). "Identification of a new thyrotropin receptor germline mutation (Leu629Phe) in a family with neonatal onset of autosomal dominant nonautoimmune hyperthyroidism". J. Clin. Endocrinol. Metab. 82 (12): 4234–8. doi:10.1210/jc.82.12.4234. PMID 9398746. 
  • Farid NR, Kascur V, Balazs C (2000). "The human thyrotropin receptor is highly mutable: a review of gain-of-function mutations". Eur. J. Endocrinol. 143 (1): 25–30. doi:10.1530/eje.0.1430025. PMID 10870027. 
  • Szkudlinski MW, Fremont V, Ronin C, Weintraub BD (2002). "Thyroid-stimulating hormone and thyroid-stimulating hormone receptor structure-function relationships". Physiol. Rev. 82 (2): 473–502. doi:10.1152/physrev.00031.2001. PMID 11917095. 
  • Tonacchera M, Vitti P, De Servi M; et al. (2004). "Gain of function TSH receptor mutations and iodine deficiency: implications in iodine prophylaxis". J. Endocrinol. Invest. 26 (2 Suppl): 2–6. PMID 12762632. 
  • Arturi F, Scarpelli D, Coco A; et al. (2004). "Thyrotropin receptor mutations and thyroid hyperfunctioning adenomas ten years after their first discovery: unresolved questions". Thyroid. 13 (4): 341–3. doi:10.1089/105072503321669811. PMID 12804102. 
  • Vaidya B, Campbell V, Tripp JH; et al. (2004). "Premature birth and low birth weight associated with nonautoimmune hyperthyroidism due to an activating thyrotropin receptor gene mutation". Clin. Endocrinol. (Oxf). 60 (6): 711–8. doi:10.1111/j.1365-2265.2004.02040.x. PMID 15163335. 
  • Takeshita A, Nagayama Y, Fujiyama K; et al. (1992). "Molecular cloning and sequencing of an alternatively spliced form of the human thyrotropin receptor transcript". Biochem. Biophys. Res. Commun. 188 (3): 1214–9. doi:10.1016/0006-291X(92)91360-3. PMID 1445355. 
  • Graves PN, Tomer Y, Davies TF (1992). "Cloning and sequencing of a 1.3 KB variant of human thyrotropin receptor mRNA lacking the transmembrane domain". Biochem. Biophys. Res. Commun. 187 (2): 1135–43. doi:10.1016/0006-291X(92)91315-H. PMID 1530609. 
  • Loosfelt H, Pichon C, Jolivet A; et al. (1992). "Two-subunit structure of the human thyrotropin receptor". Proc. Natl. Acad. Sci. U.S.A. 89 (9): 3765–9. doi:10.1073/pnas.89.9.3765. PMC 525571Freely accessible. PMID 1570295. 
  • Nagayama Y, Russo D, Wadsworth HL; et al. (1991). "Eleven amino acids (Lys-201 to Lys-211) and 9 amino acids (Gly-222 to Leu-230) in the human thyrotropin receptor are involved in ligand binding". J. Biol. Chem. 266 (23): 14926–30. PMID 1651314. 
  • Murakami M, Mori M (1990). "Identification of immunogenic regions in human thyrotropin receptor for immunoglobulin G of patients with Graves' disease". Biochem. Biophys. Res. Commun. 171 (1): 512–8. doi:10.1016/0006-291X(90)91423-P. PMID 1697467. 
  • Heldin NE, Gustavsson B, Westermark K, Westermark B (1992). "A somatic point mutation in a putative ligand binding domain of the TSH receptor in a patient with autoimmune hyperthyroidism". J. Clin. Endocrinol. Metab. 73 (6): 1374–6. doi:10.1210/jcem-73-6-1374. PMID 1955520. 
  • Libert F, Passage E, Lefort A; et al. (1991). "Localization of human thyrotropin receptor gene to chromosome region 14q3 by in situ hybridization". Cytogenet. Cell Genet. 54 (1-2): 82–3. doi:10.1159/000132964. PMID 2249482. 
  • Frazier AL, Robbins LS, Stork PJ; et al. (1991). "Isolation of TSH and LH/CG receptor cDNAs from human thyroid: regulation by tissue specific splicing". Mol. Endocrinol. 4 (8): 1264–76. doi:10.1210/mend-4-8-1264. PMID 2293030. 
  • Misrahi M, Loosfelt H, Atger M; et al. (1990). "Cloning, sequencing and expression of human TSH receptor". Biochem. Biophys. Res. Commun. 166 (1): 394–403. doi:10.1016/0006-291X(90)91958-U. PMID 2302212. 
  • Nagayama Y, Kaufman KD, Seto P, Rapoport B (1990). "Molecular cloning, sequence and functional expression of the cDNA for the human thyrotropin receptor". Biochem. Biophys. Res. Commun. 165 (3): 1184–90. doi:10.1016/0006-291X(89)92727-7. PMID 2558651. 
  • Libert F, Lefort A, Gerard C; et al. (1990). "Cloning, sequencing and expression of the human thyrotropin (TSH) receptor: evidence for binding of autoantibodies". Biochem. Biophys. Res. Commun. 165 (3): 1250–5. doi:10.1016/0006-291X(89)92736-8. PMID 2610690. 
  • Cuddihy RM, Bryant WP, Bahn RS (1996). "Normal function in vivo of a homozygotic polymorphism in the human thyrotropin receptor". Thyroid. 5 (4): 255–7. doi:10.1089/thy.1995.5.255. PMID 7488864. 
  • Bahn RS, Dutton CM, Heufelder AE, Sarkar G (1994). "A genomic point mutation in the extracellular domain of the thyrotropin receptor in patients with Graves' ophthalmopathy". J. Clin. Endocrinol. Metab. 78 (2): 256–60. doi:10.1210/jc.78.2.256. PMID 7508946. 
  • Sunthornthepvarakui T, Gottschalk ME, Hayashi Y, Refetoff S (1995). "Brief report: resistance to thyrotropin caused by mutations in the thyrotropin-receptor gene". N. Engl. J. Med. 332 (3): 155–60. doi:10.1056/NEJM199501193320305. PMID 7528344. 

External links

pt:Receptor de tirotrofina
  1. Farid NR, Szkudlinski MW (2004). "Minireview: structural and functional evolution of the thyrotropin receptor". Endocrinology. 145 (9): 4048–57. doi:10.1210/en.2004-0437. PMID 15231707. 
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