Thyrotropin receptor
From Self-sufficiency
Not to be confused with Thyrotropin-releasing hormone or Thyrotropin-releasing hormone receptor.
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The thyrotropin receptor (or TSH receptor) is a receptor (and associated protein) that responds to thyroid-stimulating hormone (also known as "thyrotropin", and stimulates the production of thyroxine (T4) and triiodothyronine (T3). The TSH receptor is a member of the G protein-coupled receptor superfamily of integral membrane proteins[1] and is coupled to the Gs protein.[2]
It is primarily found on the surface of the thyroid epithelial cells.
See also
References
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- Führer D, Wonerow P, Willgerodt H, Paschke R (1998). "Identification of a new thyrotropin receptor germline mutation (Leu629Phe) in a family with neonatal onset of autosomal dominant nonautoimmune hyperthyroidism". J. Clin. Endocrinol. Metab. 82 (12): 4234–8. doi:10.1210/jc.82.12.4234. PMID 9398746.
- Farid NR, Kascur V, Balazs C (2000). "The human thyrotropin receptor is highly mutable: a review of gain-of-function mutations". Eur. J. Endocrinol. 143 (1): 25–30. doi:10.1530/eje.0.1430025. PMID 10870027.
- Szkudlinski MW, Fremont V, Ronin C, Weintraub BD (2002). "Thyroid-stimulating hormone and thyroid-stimulating hormone receptor structure-function relationships". Physiol. Rev. 82 (2): 473–502. doi:10.1152/physrev.00031.2001. PMID 11917095.
- Tonacchera M, Vitti P, De Servi M; et al. (2004). "Gain of function TSH receptor mutations and iodine deficiency: implications in iodine prophylaxis". J. Endocrinol. Invest. 26 (2 Suppl): 2–6. PMID 12762632.
- Arturi F, Scarpelli D, Coco A; et al. (2004). "Thyrotropin receptor mutations and thyroid hyperfunctioning adenomas ten years after their first discovery: unresolved questions". Thyroid. 13 (4): 341–3. doi:10.1089/105072503321669811. PMID 12804102.
- Vaidya B, Campbell V, Tripp JH; et al. (2004). "Premature birth and low birth weight associated with nonautoimmune hyperthyroidism due to an activating thyrotropin receptor gene mutation". Clin. Endocrinol. (Oxf). 60 (6): 711–8. doi:10.1111/j.1365-2265.2004.02040.x. PMID 15163335.
- Takeshita A, Nagayama Y, Fujiyama K; et al. (1992). "Molecular cloning and sequencing of an alternatively spliced form of the human thyrotropin receptor transcript". Biochem. Biophys. Res. Commun. 188 (3): 1214–9. doi:10.1016/0006-291X(92)91360-3. PMID 1445355.
- Graves PN, Tomer Y, Davies TF (1992). "Cloning and sequencing of a 1.3 KB variant of human thyrotropin receptor mRNA lacking the transmembrane domain". Biochem. Biophys. Res. Commun. 187 (2): 1135–43. doi:10.1016/0006-291X(92)91315-H. PMID 1530609.
- Loosfelt H, Pichon C, Jolivet A; et al. (1992). "Two-subunit structure of the human thyrotropin receptor". Proc. Natl. Acad. Sci. U.S.A. 89 (9): 3765–9. doi:10.1073/pnas.89.9.3765. PMC 525571 Freely accessible. PMID 1570295.
- Nagayama Y, Russo D, Wadsworth HL; et al. (1991). "Eleven amino acids (Lys-201 to Lys-211) and 9 amino acids (Gly-222 to Leu-230) in the human thyrotropin receptor are involved in ligand binding". J. Biol. Chem. 266 (23): 14926–30. PMID 1651314.
- Murakami M, Mori M (1990). "Identification of immunogenic regions in human thyrotropin receptor for immunoglobulin G of patients with Graves' disease". Biochem. Biophys. Res. Commun. 171 (1): 512–8. doi:10.1016/0006-291X(90)91423-P. PMID 1697467.
- Heldin NE, Gustavsson B, Westermark K, Westermark B (1992). "A somatic point mutation in a putative ligand binding domain of the TSH receptor in a patient with autoimmune hyperthyroidism". J. Clin. Endocrinol. Metab. 73 (6): 1374–6. doi:10.1210/jcem-73-6-1374. PMID 1955520.
- Libert F, Passage E, Lefort A; et al. (1991). "Localization of human thyrotropin receptor gene to chromosome region 14q3 by in situ hybridization". Cytogenet. Cell Genet. 54 (1-2): 82–3. doi:10.1159/000132964. PMID 2249482.
- Frazier AL, Robbins LS, Stork PJ; et al. (1991). "Isolation of TSH and LH/CG receptor cDNAs from human thyroid: regulation by tissue specific splicing". Mol. Endocrinol. 4 (8): 1264–76. doi:10.1210/mend-4-8-1264. PMID 2293030.
- Misrahi M, Loosfelt H, Atger M; et al. (1990). "Cloning, sequencing and expression of human TSH receptor". Biochem. Biophys. Res. Commun. 166 (1): 394–403. doi:10.1016/0006-291X(90)91958-U. PMID 2302212.
- Nagayama Y, Kaufman KD, Seto P, Rapoport B (1990). "Molecular cloning, sequence and functional expression of the cDNA for the human thyrotropin receptor". Biochem. Biophys. Res. Commun. 165 (3): 1184–90. doi:10.1016/0006-291X(89)92727-7. PMID 2558651.
- Libert F, Lefort A, Gerard C; et al. (1990). "Cloning, sequencing and expression of the human thyrotropin (TSH) receptor: evidence for binding of autoantibodies". Biochem. Biophys. Res. Commun. 165 (3): 1250–5. doi:10.1016/0006-291X(89)92736-8. PMID 2610690.
- Cuddihy RM, Bryant WP, Bahn RS (1996). "Normal function in vivo of a homozygotic polymorphism in the human thyrotropin receptor". Thyroid. 5 (4): 255–7. doi:10.1089/thy.1995.5.255. PMID 7488864.
- Bahn RS, Dutton CM, Heufelder AE, Sarkar G (1994). "A genomic point mutation in the extracellular domain of the thyrotropin receptor in patients with Graves' ophthalmopathy". J. Clin. Endocrinol. Metab. 78 (2): 256–60. doi:10.1210/jc.78.2.256. PMID 7508946.
- Sunthornthepvarakui T, Gottschalk ME, Hayashi Y, Refetoff S (1995). "Brief report: resistance to thyrotropin caused by mutations in the thyrotropin-receptor gene". N. Engl. J. Med. 332 (3): 155–60. doi:10.1056/NEJM199501193320305. PMID 7528344.
External links
- "Glycoprotein Hormone Receptors: TSH". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
- MeSH Thyrotropin+Receptors
- GRIS: Glycoprotein-hormone Receptor Information System
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