Prostacyclin receptor

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Prostaglandin I2 (prostacyclin) receptor (IP1)
Identifiers
SymbolsPTGIR; IP; MGC102830; PRIPR
External IDsOMIM: 600022 MGI: 99535 HomoloGene: 7496 IUPHAR: IP1 GeneCards: PTGIR Gene
RNA expression pattern
250px
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez573919222
EnsemblENSG00000160013ENSMUSG00000043017
UniProtP43119Q3U4F1
RefSeq (mRNA)NM_000960NM_008967
RefSeq (protein)NP_000951NP_032993
Location (UCSC)Chr 19:
51.82 - 51.82 Mb		Chr 7:
16.07 - 16.07 Mb
PubMed search[1][2]

Prostacyclin receptor ( or prostaglandin I2 receptor, IP1) is a receptor for prostacyclin.

It is a member of the G-protein coupled receptor family. Prostacyclin, the major product of cyclooxygenase in macrovascular endothelium, elicits a potent vasodilation and inhibition of platelet aggregation through binding to this receptor.[1]

Transduction

When binding a prostacyclin-molecule, the receptor changes conformation and activates Gs, with its activation of cAMP and increase in protein kinase A (PKA) activity.

In vasodilation

In vasodilation, the PKA activity causes phosphorylation of MLCK, decreasing its activity, resulting in dephosphorylation of MLC of myosin. The smooth muscle relaxation leads to vasodilation.[2]

Gene

The receptor is encoded by the human gene PTGIR.[1]


See also

References

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External links

Further reading

  • Coleman RA, Smith WL, Narumiya S (1994). "International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes". Pharmacol. Rev. 46 (2): 205–29. PMID 7938166. 
  • Rauvala H, Peng HB (1997). "HB-GAM (heparin-binding growth-associated molecule) and heparin-type glycans in the development and plasticity of neuron-target contacts". Prog. Neurobiol. 52 (2): 127–44. doi:10.1016/S0301-0082(97)00007-5. PMID 9185236. 
  • Smyth EM, FitzGerald GA (2003). "Human prostacyclin receptor". Vitam. Horm. 65: 149–65. doi:10.1016/S0083-6729(02)65063-0. PMID 12481546. 
  • Boie Y, Rushmore TH, Darmon-Goodwin A; et al. (1994). "Cloning and expression of a cDNA for the human prostanoid IP receptor". J. Biol. Chem. 269 (16): 12173–8. PMID 7512962. 
  • Katsuyama M, Sugimoto Y, Namba T; et al. (1994). "Cloning and expression of a cDNA for the human prostacyclin receptor". FEBS Lett. 344 (1): 74–8. doi:10.1016/0014-5793(94)00355-6. PMID 7514139. 
  • Ogawa Y, Tanaka I, Inoue M; et al. (1995). "Structural organization and chromosomal assignment of the human prostacyclin receptor gene". Genomics. 27 (1): 142–8. doi:10.1006/geno.1995.1016. PMID 7665161. 
  • Duncan AM, Anderson LL, Funk CD; et al. (1995). "Chromosomal localization of the human prostanoid receptor gene family". Genomics. 25 (3): 740–2. doi:10.1016/0888-7543(95)80022-E. PMID 7759114. 
  • Nakagawa O, Tanaka I, Usui T; et al. (1994). "Molecular cloning of human prostacyclin receptor cDNA and its gene expression in the cardiovascular system". Circulation. 90 (4): 1643–7. PMID 7923647. 
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548. 
  • Sasaki Y, Takahashi T, Tanaka I; et al. (1997). "Expression of prostacyclin receptor in human megakaryocytes". Blood. 90 (3): 1039–46. PMID 9242534. 
  • Fisch A, Tobusch K, Veit K; et al. (1997). "Prostacyclin receptor desensitization is a reversible phenomenon in human platelets". Circulation. 96 (3): 756–60. PMID 9264479. 
  • Smyth EM, Li WH, FitzGerald GA (1998). "Phosphorylation of the prostacyclin receptor during homologous desensitization. A critical role for protein kinase c". J. Biol. Chem. 273 (36): 23258–66. doi:10.1074/jbc.273.36.23258. PMID 9722557. 
  • Kömhoff M, Lesener B, Nakao K; et al. (1999). "Localization of the prostacyclin receptor in human kidney". Kidney Int. 54 (6): 1899–908. doi:10.1046/j.1523-1755.1998.00213.x. PMID 9853255. 
  • Hayes JS, Lawler OA, Walsh MT, Kinsella BT (1999). "The prostacyclin receptor is isoprenylated. Isoprenylation is required for efficient receptor-effector coupling". J. Biol. Chem. 274 (34): 23707–18. doi:10.1074/jbc.274.34.23707. PMID 10446129. 
  • Smyth EM, Austin SC, Reilly MP, FitzGerald GA (2000). "Internalization and sequestration of the human prostacyclin receptor". J. Biol. Chem. 275 (41): 32037–45. doi:10.1074/jbc.M003873200. PMID 10889200. 
  • Lawler OA, Miggin SM, Kinsella BT (2001). "Protein kinase A-mediated phosphorylation of serine 357 of the mouse prostacyclin receptor regulates its coupling to G(s)-, to G(i)-, and to G(q)-coupled effector signaling". J. Biol. Chem. 276 (36): 33596–607. doi:10.1074/jbc.M104434200. PMID 11443126. 
  • Zhang Z, Austin SC, Smyth EM (2001). "Glycosylation of the human prostacyclin receptor: role in ligand binding and signal transduction". Mol. Pharmacol. 60 (3): 480–7. PMID 11502878. 
  • Fortier I, Patry C, Lora M; et al. (2001). "Immunohistochemical localization of the prostacyclin receptor (IP) human bone". Prostaglandins Leukot. Essent. Fatty Acids. 65 (2): 79–83. doi:10.1054/plef.2001.0292. PMID 11545623. 
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Class A: Rhodopsin like
α1 (A, B, D) · α2 (A, B, C) · β1 · β2 · β3
Adenosine (A1, A2A, A2B, A3) · P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
(all but 5-HT3) 5-HT1 (A, B, D, E, F) · 5-HT2 (A, B, C) · 5-HT (4, 5A, 6, 7)
Other
Acetylcholine (M1, M2, M3, M4, M5) · Dopamine (D1, D2, D3, D4, D5) · Histamine (H1, H2, H3, H4) · Melatonin (1A, 1B, 1C) · TAAR (1, 2, 3, 5, 6, 8, 9)
Metabolites and
signaling molecules
CysLT (1, 2) · LTB4 (1, 2) · FPRL1 · OXE · Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) · Prostacyclin · Thromboxane
Other
Bile acid · Cannabinoid (CB1, CB2, GPR (18, 55, 119)) · EBI2 · Estrogen · Free fatty acid (1, 2, 3, 4) · Lactate  · Lysophosphatidic acid (1, 2, 3, 4, 5, 6)  · Lysophospholipid (1, 2, 3, 4, 5, 6, 7, 8) · Niacin (1, 2) · Oxoglutarate · PAF · Sphingosine-1-phosphate (1, 2, 3, 4, 5) · Succinate
Peptide
B/W (1, 2) · FF (1, 2) · S · Y (1, 2, 4, 5) · Neuromedin (B, U (1, 2)) · Neurotensin (1, 2)
Other
Miscellaneous
GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Other
Class B: Secretin like
GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Other
Class C: Metabotropic
glutamate / pheromone
TAS1R (1, 2, 3) · TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Other
Class F:
Frizzled / Smoothened
Frizzled
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Smoothened
de:Prostacyclin-Rezeptor
  1. ↑ 1.0 1.1 "Entrez Gene: PTGIR prostaglandin I2 (prostacyclin) receptor (IP)". 
  2. ↑ Walter F., PhD. Boron (2005). Medical Physiology: A Cellular And Molecular Approaoch. Elsevier/Saunders. ISBN 1-4160-2328-3.  Page 479
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