GPR50

From Self-sufficiency
Jump to: navigation, search
edit
G protein-coupled receptor 50
Identifiers
SymbolsGPR50; H9; MGC125342
External IDsOMIM300207 MGI1333877 HomoloGene3113 IUPHAR: GPR50 GeneCards: GPR50 Gene
RNA expression pattern
250px
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez924814765
EnsemblENSG00000102195ENSMUSG00000056380
UniProtQ13585Q3V1S8
RefSeq (mRNA)NM_004224XM_990925
RefSeq (protein)NP_004215XP_996019
Location (UCSC)Chr X:
150.1 - 150.1 Mb
Chr X:
67.92 - 67.93 Mb
PubMed search[1][2]

G protein-coupled receptor 50 is a protein which in humans is encoded by the GPR50 gene.[1][2][3]

Function

GPR50 is a member of the G protein-coupled receptor family of integral membrane proteins and is most closely related to the melatonin receptor.[2] GPR50 is able to heterodimerize with both the MT1 and MT2 melatonin receptor subtypes. While GPR50 has no effect on MT2 function, GPR50 prevented MT1 from both binding melatonin and coupling to G proteins.[4]

Clinical significance

Certain polymorphisms of the GPR50 gene in females are associated with increased risk of developing bipolar affective disorder, major depressive disorder, and schizophrenia.[5] Other GPR50 gene polymorphism are associated with higher fasting circulating triglyceride levels and lower circulating High-density lipoprotein levels.[6]

References

Cite error: Invalid <references> tag; parameter "group" is allowed only.

Use <references />, or <references group="..." />

Further reading

  1. "Entrez Gene: GPR50 G protein-coupled receptor 50". 
  2. 2.0 2.1 Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
  3. Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
  4. Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
  5. Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
  6. Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.