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Gamma-aminobutyric acid (GABA) B receptor, 1
PDB rendering based on 1srz.
SymbolsGABBR1; GABAB(1e); GABABR1; GABBR1-3; GPRC3A; dJ271M21.1.1; dJ271M21.1.2; hGB1a
External IDsOMIM603540 MGI1860139 HomoloGene1132 IUPHAR: GABAB1 GeneCards: GABBR1 Gene
RNA expression pattern
More reference expression data
RefSeq (mRNA)NM_001470XM_001001239
RefSeq (protein)NP_001461XP_001001239
Location (UCSC)Chr 6:
29.63 - 29.78 Mb
Chr 17:
36.65 - 36.68 Mb
PubMed search[1][2]

Gamma-aminobutyric acid (GABA) B receptor, 1 (GABAB1), is a G-protein coupled receptor subunit encoded by the GABBR1 gene.

Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the mammalian central nervous system. GABA exerts its effects through ionotropic [GABA(A/C)] receptors, to produce fast synaptic inhibition, and metabotropic [GABA(B)] receptors, to produce slow, prolonged inhibitory signals. The GABA(B) receptor consists of a heterodimer of two related 7-transmembrane receptors, GABA(B) receptor 1 and GABA(B) receptor 2. The GABA(B) receptor 1 gene is mapped to chromosome 6p21.3 within the HLA class I region close to the HLA-F gene. Susceptibility loci for multiple sclerosis, epilepsy, and schizophrenia have also been mapped in this region. Alternative splicing of this gene generates 4 transcript variants.[1]


GABBR1 has been shown to interact with ATF4[2] and GABBR2.[3]

See also


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External links

  • "GABAB Receptors: GABAB1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

Further reading

  • Fraser DD, Mudrick-Donnon LA, MacVicar BA (1994). "Astrocytic GABA receptors". Glia. 11 (2): 83–93. doi:10.1002/glia.440110203. PMID 7927650. 
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
  • Kaupmann K, Huggel K, Heid J; et al. (1997). "Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors". Nature. 386 (6622): 239–46. doi:10.1038/386239a0. PMID 9069281. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
  • Grifa A, Totaro A, Rommens JM; et al. (1998). "GABA (gamma-amino-butyric acid) neurotransmission: identification and fine mapping of the human GABAB receptor gene". Biochem. Biophys. Res. Commun. 250 (2): 240–5. doi:10.1006/bbrc.1998.9296. PMID 9753614. 
  • Goei VL, Choi J, Ahn J; et al. (1999). "Human gamma-aminobutyric acid B receptor gene: complementary DNA cloning, expression, chromosomal location, and genomic organization". Biol. Psychiatry. 44 (8): 659–66. doi:10.1016/S0006-3223(98)00244-3. PMID 9798068. 
  • Kaupmann K, Schuler V, Mosbacher J; et al. (1999). "Human gamma-aminobutyric acid type B receptors are differentially expressed and regulate inwardly rectifying K+ channels". Proc. Natl. Acad. Sci. U.S.A. 95 (25): 14991–6. doi:10.1073/pnas.95.25.14991. PMC 24563Freely accessible. PMID 9844003. 
  • White JH, Wise A, Main MJ; et al. (1999). "Heterodimerization is required for the formation of a functional GABA(B) receptor". Nature. 396 (6712): 679–82. doi:10.1038/25354. PMID 9872316. 
  • Kuner R, Köhr G, Grünewald S; et al. (1999). "Role of heteromer formation in GABAB receptor function". Science. 283 (5398): 74–7. doi:10.1126/science.283.5398.74. PMID 9872744. 
  • Makoff A (1999). "Molecular cloning of human GABABR1 and its tissue distribution". Brain Res. Mol. Brain Res. 64 (1): 137–40. doi:10.1016/S0169-328X(98)00316-7. PMID 9889352. 
  • Peters HC, Kämmer G, Volz A; et al. (2000). "Mapping, genomic structure, and polymorphisms of the human GABABR1 receptor gene: evaluation of its involvement in idiopathic generalized epilepsy". Neurogenetics. 2 (1): 47–54. doi:10.1007/s100480050051. PMID 9933300. 
  • Ng GY, Clark J, Coulombe N; et al. (1999). "Identification of a GABAB receptor subunit, gb2, required for functional GABAB receptor activity". J. Biol. Chem. 274 (12): 7607–10. doi:10.1074/jbc.274.12.7607. PMID 10075644. 
  • Sander T, Peters C, Kämmer G; et al. (1999). "Association analysis of exonic variants of the gene encoding the GABAB receptor and idiopathic generalized epilepsy". Am. J. Med. Genet. 88 (4): 305–10. doi:10.1002/(SICI)1096-8628(19990820)88:4<305::AID-AJMG5>3.0.CO;2-X. PMID 10402495. 
  • Wise A, Green A, Main MJ; et al. (1999). "Calcium sensing properties of the GABA(B) receptor". Neuropharmacology. 38 (11): 1647–56. doi:10.1016/S0028-3908(99)00119-7. PMID 10587080. 
  • Sullivan R, Chateauneuf A, Coulombe N; et al. (2000). "Coexpression of full-length gamma-aminobutyric acid(B) (GABA(B)) receptors with truncated receptors and metabotropic glutamate receptor 4 supports the GABA(B) heterodimer as the functional receptor". J. Pharmacol. Exp. Ther. 293 (2): 460–7. PMID 10773016. 
  • Schwarz DA, Barry G, Eliasof SD; et al. (2000). "Characterization of gamma-aminobutyric acid receptor GABAB(1e), a GABAB(1) splice variant encoding a truncated receptor". J. Biol. Chem. 275 (41): 32174–81. doi:10.1074/jbc.M005333200. PMID 10906333. 
  • White JH, McIllhinney RA, Wise A; et al. (2001). "The GABAB receptor interacts directly with the related transcription factors CREB2 and ATFx". Proc. Natl. Acad. Sci. U.S.A. 97 (25): 13967–72. doi:10.1073/pnas.240452197. PMC 17684Freely accessible. PMID 11087824. 
  • Couve A, Kittler JT, Uren JM; et al. (2001). "Association of GABA(B) receptors and members of the 14-3-3 family of signaling proteins". Mol. Cell. Neurosci. 17 (2): 317–28. doi:10.1006/mcne.2000.0938. PMID 11178869. 
  • Muñoz A, Arellano JI, DeFelipe J (2002). "GABABR1 receptor protein expression in human mesial temporal cortex: changes in temporal lobe epilepsy". J. Comp. Neurol. 449 (2): 166–79. doi:10.1002/cne.10287. PMID 12115687. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

  1. "Entrez Gene: GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1". 
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