Gastric inhibitory polypeptide receptor

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Gastric inhibitory polypeptide receptor
Identifiers
SymbolsGIPR; MGC126722
External IDsOMIM137241 MGI1352753 HomoloGene20081 IUPHAR: GIP GeneCards: GIPR Gene
RNA expression pattern
250px
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez2696381853
EnsemblENSG00000010310ENSMUSG00000030406
UniProtP48546Q0P543
RefSeq (mRNA)NM_000164XM_133238
RefSeq (protein)NP_000155XP_133238
Location (UCSC)Chr 19:
50.86 - 50.88 Mb
Chr 7:
18.32 - 18.32 Mb
PubMed search[1][2]

The gastric inhibitory polypeptide receptor (GIP-R) also known as the glucose-dependent insulinotropic polypeptide receptor is a protein that in humans is encoded by the GIPR gene.[1][2] The GIP-R is seven-transmembrane proteins found on beta-cells in the pancreas.[3][4]

Function

Gastric inhibitory polypeptide (GIP), also called glucose-dependent insulinotropic polypeptide, is a 42-amino acid polypeptide synthesized by K cells of the duodenum and small intestine. It was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release potently in the presence of elevated glucose. The insulinotropic effect on pancreatic islet beta-cells was then recognized to be the principal physiologic action of GIP. Together with glucagon-like peptide-1, GIP is largely responsible for the secretion of insulin after eating. It is involved in several other facets of the anabolic response.[1]

References

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Further reading

  • Yamada Y, Seino Y (2005). "Physiology of GIP--a lesson from GIP receptor knockout mice". Horm. Metab. Res. 36 (11-12): 771–4. doi:10.1055/s-2004-826162. PMID 15655707. 
  • Gremlich S, Porret A, Hani EH; et al. (1995). "Cloning, functional expression, and chromosomal localization of the human pancreatic islet glucose-dependent insulinotropic polypeptide receptor". Diabetes. 44 (10): 1202–8. doi:10.2337/diabetes.44.10.1202. PMID 7556958. 
  • Volz A, Göke R, Lankat-Buttgereit B; et al. (1995). "Molecular cloning, functional expression, and signal transduction of the GIP-receptor cloned from a human insulinoma". FEBS Lett. 373 (1): 23–9. doi:10.1016/0014-5793(95)01006-Z. PMID 7589426. 
  • Usdin TB, Mezey E, Button DC; et al. (1994). "Gastric inhibitory polypeptide receptor, a member of the secretin-vasoactive intestinal peptide receptor family, is widely distributed in peripheral organs and the brain". Endocrinology. 133 (6): 2861–70. doi:10.1210/en.133.6.2861. PMID 8243312. 
  • Yamada Y, Hayami T, Nakamura K; et al. (1996). "Human gastric inhibitory polypeptide receptor: cloning of the gene (GIPR) and cDNA". Genomics. 29 (3): 773–6. doi:10.1006/geno.1995.9937. PMID 8575774. 
  • Gallwitz B, Witt M, Morys-Wortmann C; et al. (1997). "GLP-1/GIP chimeric peptides define the structural requirements for specific ligand-receptor interaction of GLP-1". Regul. Pept. 63 (1): 17–22. doi:10.1016/0167-0115(96)00019-5. PMID 8795084. 
  • N'Diaye N, Tremblay J, Hamet P; et al. (1998). "Adrenocortical overexpression of gastric inhibitory polypeptide receptor underlies food-dependent Cushing's syndrome". J. Clin. Endocrinol. Metab. 83 (8): 2781–5. doi:10.1210/jc.83.8.2781. PMID 9709947. 
  • Tseng CC, Zhang XY (2000). "Role of G protein-coupled receptor kinases in glucose-dependent insulinotropic polypeptide receptor signaling". Endocrinology. 141 (3): 947–52. doi:10.1210/en.141.3.947. PMID 10698169. 
  • Bollag RJ, Zhong Q, Phillips P; et al. (2000). "Osteoblast-derived cells express functional glucose-dependent insulinotropic peptide receptors". Endocrinology. 141 (3): 1228–35. doi:10.1210/en.141.3.1228. PMID 10698200. 
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241Freely accessible. PMID 12477932. 
  • Baldacchino V, Oble S, Hamet P; et al. (2003). "Partial characterisation of the 5' flanking region of the human GIP receptor (GIPR) gene". Endocr. Res. 28 (4): 577. doi:10.1081/ERC-120016843. PMID 12530665. 
  • Antonini SR, N'Diaye N, Hamet P; et al. (2003). "Analysis of the putative promoter region of the GIP receptor gene (GIPR) in GIP-dependent Cushing's syndrome (CS)". Endocr. Res. 28 (4): 755–6. doi:10.1081/ERC-120017003. PMID 12530694. 
  • Manhart S, Hinke SA, McIntosh CH; et al. (2003). "Structure-function analysis of a series of novel GIP analogues containing different helical length linkers". Biochemistry. 42 (10): 3081–8. doi:10.1021/bi026868e. PMID 12627975. 
  • Ding KH, Zhong Q, Isales CM (2003). "Glucose-dependent insulinotropic peptide stimulates thymidine incorporation in endothelial cells: role of endothelin-1". Am. J. Physiol. Endocrinol. Metab. 285 (2): E390–6. doi:10.1152/ajpendo.00509.2002. PMID 12721154. 
  • Grimwood J, Gordon LA, Olsen A; et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824. 
  • Hansotia T, Baggio LL, Delmeire D; et al. (2004). "Double incretin receptor knockout (DIRKO) mice reveal an essential role for the enteroinsular axis in transducing the glucoregulatory actions of DPP-IV inhibitors". Diabetes. 53 (5): 1326–35. doi:10.2337/diabetes.53.5.1326. PMID 15111503. 
  • Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928Freely accessible. PMID 15489334. 
  • Baldacchino V, Oble S, Hamet P; et al. (2005). "The Sp transcription factor family is involved in the cellular expression of the human GIP-R gene promoter". Endocr. Res. 30 (4): 805–6. doi:10.1081/ERC-200044046. PMID 15666829. 

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

  1. 1.0 1.1 "Entrez Gene: gastric inhibitory polypeptide receptor". 
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  3. "Gastrointestinal Hormones and Peptides". Retrieved 2007-08-24. 
  4. Brubaker PL, Drucker DJ (2002). "Structure-function of the glucagon receptor family of G protein-coupled receptors: the glucagon, GIP, GLP-1, and GLP-2 receptors". Recept. Channels. 8 (3-4): 179–88. doi:10.1080/10606820213687+]</sup>. PMID 12529935.