GPR18

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G protein-coupled receptor 18
Identifiers
Symbols	GPR18;
External IDs	OMIM: 602042 MGI: 107859 HomoloGene: 18814 IUPHAR: GPR18 GeneCards: GPR18 Gene
Gene Ontology Molecular function • rhodopsin-like receptor activity • receptor activity • purinergic nucleotide receptor activity, G-protein coupled Cellular component • membrane • integral to membrane Biological process • signal transduction • G-protein coupled receptor protein signaling pathway Sources: Amigo / EGO
RNA expression pattern
250px
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2841	110168
Ensembl	ENSG00000125245	ENSMUSG00000050350
UniProt	Q14330	n/a
RefSeq (mRNA)	NM_005292	NM_182806
RefSeq (protein)	NP_005283	NP_877958
Location (UCSC)	Chr 13: 98.7 - 98.71 Mb	Chr 14: 121.05 - 121.05 Mb
PubMed search	[1]	[2]

N-arachidonyl glycine receptor also known as G-protein coupled receptor 18 (GPR18) is a protein that in humans is encoded by the GPR18 gene. Along with the other previously "orphan" receptors GPR55 and GPR119, GPR18 has been found to be a receptor for endogenous lipid neurotransmitters, several of which also bind to cannabinoid receptors. Recent research strongly supports the hypothesis that GPR18 is the molecular identity of the abnormal cannabidiol receptor and additionally suggests that N-arachidonoyl glycine, the endogenous lipid metabolite of anandamide, initiates directed microglial migration in the CNS through activation of GPR18.

Ligands

Ligands found to bind to GPR18 include:

• Abnormal cannabidiol
• N-arachidonoyl glycine

Further reading

• Christian SL, McDonough J, Liu Cy CY; et al. (2002). "An evaluation of the assembly of an approximately 15-Mb region on human chromosome 13q32-q33 linked to bipolar disorder and schizophrenia". Genomics. 79 (5): 635–56. doi:10.1006/geno.2002.6765. PMID 11991713. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241 Freely accessible. PMID 12477932. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dunham A, Matthews LH, Burton J; et al. (2004). "The DNA sequence and analysis of human chromosome 13". Nature. 428 (6982): 522–8. doi:10.1038/nature02379. PMC 2665288 Freely accessible. PMID 15057823. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 Freely accessible. PMID 15489334. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kohno M, Hasegawa H, Inoue A; et al. (2006). "Identification of N-arachidonylglycine as the endogenous ligand for orphan G-protein-coupled receptor GPR18". Biochem. Biophys. Res. Commun. 347 (3): 827–32. doi:10.1016/j.bbrc.2006.06.175. PMID 16844083. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)