TAS2R4

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Taste receptor, type 2, member 4
Identifiers
Symbols	TAS2R4; MGC163311; T2R4
External IDs	OMIM: 604869 MGI: 2681210 HomoloGene: 49480 GeneCards: TAS2R4 Gene
Gene Ontology Molecular function • receptor activity • G-protein coupled receptor activity • taste receptor activity Cellular component • membrane • integral to membrane Biological process • signal transduction • G-protein coupled receptor protein signaling pathway • response to stimulus • sensory perception of taste Sources: Amigo / EGO
RNA expression pattern
250px
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	50832	57253
Ensembl	ENSG00000127364	ENSMUSG00000037140
UniProt	Q9NYW5	Q9JKT3
RefSeq (mRNA)	NM_016944	NM_020502
RefSeq (protein)	NP_058640	NP_065248
Location (UCSC)	Chr 7: 141.12 - 141.13 Mb	Chr 6: 40.42 - 40.42 Mb
PubMed search	[1]	[2]

Taste receptor type 2 member 4 is a protein that in humans is encoded by the TAS2R4 gene.

This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. These apparently intronless genes encode a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes in chromosome 7 and is genetically linked to loci that influence bitter perception.

See also

• Taste receptor

Further reading

• Kinnamon SC (2000). "A plethora of taste receptors". Neuron. 25 (3): 507–10. doi:10.1016/S0896-6273(00)81054-5. PMID 10774719. 
• Margolskee RF (2002). "Molecular mechanisms of bitter and sweet taste transduction". J. Biol. Chem. 277 (1): 1–4. doi:10.1074/jbc.R100054200. PMID 11696554. 
• Montmayeur JP, Matsunami H (2002). "Receptors for bitter and sweet taste". Curr. Opin. Neurobiol. 12 (4): 366–71. doi:10.1016/S0959-4388(02)00345-8. PMID 12139982. 
• Firestein S (2000). "The good taste of genomics". Nature. 404 (6778): 552–3. doi:10.1038/35007167. PMID 10766221. 
• Matsunami H, Montmayeur JP, Buck LB (2000). "A family of candidate taste receptors in human and mouse". Nature. 404 (6778): 601–4. doi:10.1038/35007072. PMID 10766242. CS1 maint: Multiple names: authors list (link)
• Ueda T, Ugawa S, Ishida Y; et al. (2001). "Identification of coding single-nucleotide polymorphisms in human taste receptor genes involving bitter tasting". Biochem. Biophys. Res. Commun. 285 (1): 147–51. doi:10.1006/bbrc.2001.5136. PMID 11437385. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhang Y, Hoon MA, Chandrashekar J; et al. (2003). "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways". Cell. 112 (3): 293–301. doi:10.1016/S0092-8674(03)00071-0. PMID 12581520. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hillier LW, Fulton RS, Fulton LA; et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fischer A, Gilad Y, Man O, Pääbo S (2005). "Evolution of bitter taste receptors in humans and apes". Mol. Biol. Evol. 22 (3): 432–6. doi:10.1093/molbev/msi027. PMID 15496549. CS1 maint: Multiple names: authors list (link)
• Go Y, Satta Y, Takenaka O, Takahata N (2006). "Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates". Genetics. 170 (1): 313–26. doi:10.1534/genetics.104.037523. PMC 1449719 Freely accessible. PMID 15744053. CS1 maint: Multiple names: authors list (link)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.