Prolactin-releasing peptide receptor
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| Prolactin releasing hormone receptor | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | PRLHR; GPR10; GR3; MGC126539; MGC126541; PrRPR | ||||||||||||
| External IDs | OMIM: 600895 MGI: 2135956 HomoloGene: 3134 IUPHAR: PRRP GeneCards: PRLHR Gene | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 2834 | 226278 | |||||||||||
| Ensembl | ENSG00000119973 | ENSMUSG00000045052 | |||||||||||
| UniProt | P49683 | Q059H6 | |||||||||||
| RefSeq (mRNA) | NM_004248 | NM_201615 | |||||||||||
| RefSeq (protein) | NP_004239 | NP_963909 | |||||||||||
| Location (UCSC) | Chr 10: 120.34 - 120.34 Mb | Chr 19: 60.52 - 60.52 Mb | |||||||||||
| PubMed search | [1] | [2] | |||||||||||
The prolactin-releasing hormone receptor (PRRP) is a G-protein coupled receptor[1] that binds the prolactin releasing hormone.[2]
PRLHR is a 7-transmembrane domain receptor for prolactin-releasing hormone (PRLH; MIM 602663) that is highly expressed in anterior pituitary (Ozawa et al., 2002).[supplied by OMIM][3]
References
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- Hinuma S, Onda H, Fujino M (1999). "The quest for novel bioactive peptides utilizing orphan seven-transmembrane-domain receptors". J. Mol. Med. 77 (6): 495–504. doi:10.1007/s001090050403. PMID 10475064.
- Marchese A, Heiber M, Nguyen T; et al. (1996). "Cloning and chromosomal mapping of three novel genes, GPR9, GPR10, and GPR14, encoding receptors related to interleukin 8, neuropeptide Y, and somatostatin receptors". Genomics. 29 (2): 335–44. doi:10.1006/geno.1995.9996. PMID 8666380.
- Hinuma S, Habata Y, Fujii R; et al. (1998). "A prolactin-releasing peptide in the brain". Nature. 393 (6682): 272–6. doi:10.1038/30515. PMID 9607765.
- Fujii R, Fukusumi S, Hosoya M; et al. (1999). "Tissue distribution of prolactin-releasing peptide (PrRP) and its receptor". Regul. Pept. 83 (1): 1–10. doi:10.1016/S0167-0115(99)00028-2. PMID 10498338.
- Langmead CJ, Szekeres PG, Chambers JK; et al. (2000). "Characterization of the binding of [(125)I]-human prolactin releasing peptide (PrRP) to GPR10, a novel G protein coupled receptor". Br. J. Pharmacol. 131 (4): 683–8. doi:10.1038/sj.bjp.0703617. PMC 1572376 Freely accessible. PMID 11030716.
- Lin SH, Arai AC, Wang Z; et al. (2001). "The carboxyl terminus of the prolactin-releasing peptide receptor interacts with PDZ domain proteins involved in alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor clustering". Mol. Pharmacol. 60 (5): 916–23. PMID 11641419.
- Ozawa A, Yamada M, Satoh T; et al. (2002). "Transcriptional regulation of the human PRL-releasing peptide (PrRP) receptor gene by a dopamine 2 Receptor agonist: cloning and characterization of the human PrRP receptor gene and its promoter region". Mol. Endocrinol. 16 (4): 785–98. doi:10.1210/me.16.4.785. PMID 11923475.
- Takahashi K, Totsune K, Murakami O; et al. (2003). "Expression of prolactin-releasing peptide and its receptor in the human adrenal glands and tumor tissues of adrenocortical tumors, pheochromocytomas and neuroblastomas". Peptides. 23 (6): 1135–40. doi:10.1016/S0196-9781(02)00046-3. PMID 12126742.
- Kemp DM, Lin JC, Ubeda M, Habener JF (2002). "NRSF/REST confers transcriptional repression of the GPR10 gene via a putative NRSE/RE-1 located in the 5' promoter region". FEBS Lett. 531 (2): 193–8. doi:10.1016/S0014-5793(02)03502-0. PMID 12417311.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241 Freely accessible. PMID 12477932.
- Bhattacharyya S, Luan J, Challis B; et al. (2003). "Association of polymorphisms in GPR10, the gene encoding the prolactin-releasing peptide receptor with blood pressure, but not obesity, in a U.K. Caucasian population.". Diabetes. 52 (5): 1296–9. doi:10.2337/diabetes.52.5.1296. PMID 12716769.
- Deloukas P, Earthrowl ME, Grafham DV; et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 Freely accessible. PMID 15489334.
- Ellacott KL, Donald EL, Clarkson P; et al. (2005). "Characterization of a naturally-occurring polymorphism in the UHR-1 gene encoding the putative rat prolactin-releasing peptide receptor". Peptides. 26 (4): 675–81. doi:10.1016/j.peptides.2004.11.020. PMID 15752583.
- Lagerström MC, Fredriksson R, Bjarnadóttir TK; et al. (2005). "Origin of the prolactin-releasing hormone (PRLH) receptors: evidence of coevolution between PRLH and a redundant neuropeptide Y receptor during vertebrate evolution". Genomics. 85 (6): 688–703. doi:10.1016/j.ygeno.2005.02.007. PMID 15885496.
- Kimura K, Wakamatsu A, Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129 Freely accessible. PMID 16344560.
External links
- "Prolactin-Releasing Peptide Receptor". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
- MeSH PRLHR+protein,+human
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
- ↑ Marchese A, Heiber M, Nguyen T, Heng HH, Saldivia VR, Cheng R, Murphy PM, Tsui LC, Shi X, Gregor P (1995). "Cloning and chromosomal mapping of three novel genes, GPR9, GPR10, and GPR14, encoding receptors related to interleukin 8, neuropeptide Y, and somatostatin receptors". Genomics. 29 (2): 335–44. doi:10.1006/geno.1995.9996. PMID 8666380.
- ↑ Hinuma S, Habata Y, Fujii R, Kawamata Y, Hosoya M, Fukusumi S, Kitada C, Masuo Y, Asano T, Matsumoto H, Sekiguchi M, Kurokawa T, Nishimura O, Onda H, Fujino M (1998). "A prolactin-releasing peptide in the brain". Nature. 393 (6682): 272–6. doi:10.1038/30515. PMID 9607765.
- ↑ "Entrez Gene: PRLHR prolactin releasing hormone receptor".
