LPAR1

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Lysophosphatidic acid receptor 1
Identifiers
SymbolsLPAR1; EDG2; Gpcr26; LPA1; Mrec1.3; edg-2; rec.1.3; vzg-1
External IDsOMIM: 602282 MGI: 108429 HomoloGene: 1072 IUPHAR: LPA1 GeneCards: LPAR1 Gene
RNA expression pattern
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More reference expression data
Orthologs
SpeciesHumanMouse
Entrez190214745
EnsemblENSG00000198121ENSMUSG00000038668
UniProtQ92633Q544V2
RefSeq (mRNA)NM_001401NM_010336
RefSeq (protein)NP_001392NP_034466
Location (UCSC)Chr 9:
112.68 - 112.84 Mb		Chr 4:
58.53 - 58.65 Mb
PubMed search[1][2]

Lysophosphatidic acid receptor 1 also known as LPA1 is a protein that in humans is encoded by the LPAR1 gene.[1][2][3] LPA1 is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).[4]

Function

The integral membrane protein encoded by this gene is a lysophosphatidic acid (LPA) receptor from a group known as EDG receptors. These receptors are members of the G protein-coupled receptor superfamily. Utilized by LPA for cell signaling, EDG receptors mediate diverse biologic functions, including proliferation, platelet aggregation, smooth muscle contraction, inhibition of neuroblastoma cell differentiation, chemotaxis, and tumor cell invasion. Alternative splicing of this gene has been observed and two transcript variants have been described, each encoding identical proteins. An alternate translation start codon has been identified, which results in isoforms differing in the N-terminal extracellular tail. In addition, an alternate polyadenylation site has been reported.[1]

See also

References

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Further reading

  • An S, Goetzl EJ, Lee H (1999). "Signaling mechanisms and molecular characteristics of G protein-coupled receptors for lysophosphatidic acid and sphingosine 1-phosphate". J. Cell. Biochem. Suppl. 30-31: 147–57. PMID 9893266. 
  • Contos JJ, Ishii I, Chun J (2001). "Lysophosphatidic acid receptors". Mol. Pharmacol. 58 (6): 1188–96. PMID 11093753. 
  • Moolenaar WH, Kranenburg O, Postma FR, Zondag GC (1997). "Lysophosphatidic acid: G-protein signalling and cellular responses". Curr. Opin. Cell Biol. 9 (2): 168–73. doi:10.1016/S0955-0674(97)80059-2. PMID 9069262. 
  • Fukushima N, Kimura Y, Chun J (1998). "A single receptor encoded by vzg-1/lpA1/edg-2 couples to G proteins and mediates multiple cellular responses to lysophosphatidic acid". Proc. Natl. Acad. Sci. U.S.A. 95 (11): 6151–6. doi:10.1073/pnas.95.11.6151. PMID 9600933. 
  • An S, Bleu T, Zheng Y, Goetzl EJ (1998). "Recombinant human G protein-coupled lysophosphatidic acid receptors mediate intracellular calcium mobilization". Mol. Pharmacol. 54 (5): 881–8. PMID 9804623. 
  • Cervera P, Tirard M, Barron S; et al. (2002). "Immunohistological localization of the myelinating cell-specific receptor LP(A1)". Glia. 38 (2): 126–36. doi:10.1002/glia.10054. PMID 11948806. 
  • Hama K, Bandoh K, Kakehi Y; et al. (2002). "Lysophosphatidic acid (LPA) receptors are activated differentially by biological fluids: possible role of LPA-binding proteins in activation of LPA receptors". FEBS Lett. 523 (1-3): 187–92. doi:10.1016/S0014-5793(02)02976-9. PMID 12123830. 
  • Van Leeuwen FN, Olivo C, Grivell S; et al. (2003). "Rac activation by lysophosphatidic acid LPA1 receptors through the guanine nucleotide exchange factor Tiam1". J. Biol. Chem. 278 (1): 400–6. doi:10.1074/jbc.M210151200. PMID 12393875. 
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Murph MM, Scaccia LA, Volpicelli LA, Radhakrishna H (2004). "Agonist-induced endocytosis of lysophosphatidic acid-coupled LPA1/EDG-2 receptors via a dynamin2- and Rab5-dependent pathway". J. Cell. Sci. 116 (Pt 10): 1969–80. doi:10.1242/jcs.00397. PMID 12668728. 
  • Shida D, Kitayama J, Yamaguchi H; et al. (2003). "Lysophosphatidic acid (LPA) enhances the metastatic potential of human colon carcinoma DLD1 cells through LPA1". Cancer Res. 63 (7): 1706–11. PMID 12670925. 
  • Matsuda A, Suzuki Y, Honda G; et al. (2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501. 
  • Xu J, Lai YJ, Lin WC, Lin FT (2004). "TRIP6 enhances lysophosphatidic acid-induced cell migration by interacting with the lysophosphatidic acid 2 receptor". J. Biol. Chem. 279 (11): 10459–68. doi:10.1074/jbc.M311891200. PMID 14688263. 
  • Komuro Y, Watanabe T, Kitayama J; et al. (2004). "The Immunohistochemical expression of endothelial cell differentiation gene-2 receptor in human colorectal adenomas". Hepatogastroenterology. 50 (54): 1770–3. PMID 14696401. 
  • Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Kaneider NC, Lindner J, Feistritzer C; et al. (2005). "The immune modulator FTY720 targets sphingosine-kinase-dependent migration of human monocytes in response to amyloid beta-protein and its precursor". FASEB J. 18 (11): 1309–11. doi:10.1096/fj.03-1050fje. PMID 15208267. 

External links

Class A: Rhodopsin like
α1 (A, B, D) · α2 (A, B, C) · β1 · β2 · β3
Adenosine (A1, A2A, A2B, A3) · P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
(all but 5-HT3) 5-HT1 (A, B, D, E, F) · 5-HT2 (A, B, C) · 5-HT (4, 5A, 6, 7)
Other
Acetylcholine (M1, M2, M3, M4, M5) · Dopamine (D1, D2, D3, D4, D5) · Histamine (H1, H2, H3, H4) · Melatonin (1A, 1B, 1C) · TAAR (1, 2, 3, 5, 6, 8, 9)
Metabolites and
signaling molecules
CysLT (1, 2) · LTB4 (1, 2) · FPRL1 · OXE · Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) · Prostacyclin · Thromboxane
Other
Bile acid · Cannabinoid (CB1, CB2, GPR (18, 55, 119)) · EBI2 · Estrogen · Free fatty acid (1, 2, 3, 4) · Lactate  · Lysophosphatidic acid (1, 2, 3, 4, 5, 6)  · Lysophospholipid (1, 2, 3, 4, 5, 6, 7, 8) · Niacin (1, 2) · Oxoglutarate · PAF · Sphingosine-1-phosphate (1, 2, 3, 4, 5) · Succinate
Peptide
B/W (1, 2) · FF (1, 2) · S · Y (1, 2, 4, 5) · Neuromedin (B, U (1, 2)) · Neurotensin (1, 2)
Other
Miscellaneous
GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Other
Class B: Secretin like
GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Other
Class C: Metabotropic
glutamate / pheromone
TAS1R (1, 2, 3) · TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Other
Class F:
Frizzled / Smoothened
Frizzled
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Smoothened

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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  1. ↑ 1.0 1.1 "Entrez Gene: LPAR1 Lysophosphatidic acid receptor 1". 
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