Melanocortin 3 receptor

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Melanocortin 3 receptor
Identifiers
Symbols	MC3R; MC3
External IDs	OMIM: 155540 MGI: 96929 HomoloGene: 7412 IUPHAR: MC3 GeneCards: MC3R Gene
Gene Ontology Molecular function • rhodopsin-like receptor activity • receptor activity • melanocortin receptor activity Cellular component • integral to plasma membrane • membrane Biological process • signal transduction • G-protein signaling, coupled to cyclic nucleotide second messenger • G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) Sources: Amigo / EGO
RNA expression pattern
250px
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4159	17201
Ensembl	ENSG00000124089	ENSMUSG00000038537
UniProt	P41968	Q3ZAT4
RefSeq (mRNA)	NM_019888	NM_008561
RefSeq (protein)	NP_063941	NP_032587
Location (UCSC)	Chr 20: 54.26 - 54.26 Mb	Chr 2: 171.94 - 171.94 Mb
PubMed search	[1]	[2]

Melanocortin receptor 3 is a protein that in humans is encoded by the MC3R gene.

This gene encodes MC₃, a G-protein coupled receptor for melanocyte-stimulating hormone and adrenocorticotropic hormone that is expressed in tissues other than the adrenal cortex and melanocytes. This gene maps to the same region as the locus for benign neonatal epilepsy. Mice deficient for this gene have increased fat mass despite decreased food intake suggesting a role for this gene product in the regulation of energy homeostasis.

See also

• Melanocortin receptor

External links

• "Melanocortin Receptors: MC₃". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

Further reading

• Magenis RE, Smith L, Nadeau JH; et al. (1994). "Mapping of the ACTH, MSH, and neural (MC3 and MC4) melanocortin receptors in the mouse and human". Mamm. Genome. 5 (8): 503–8. doi:10.1007/BF00369320. PMID 7949735. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Konda Y, Gantz I, DelValle J; et al. (1994). "Interaction of dual intracellular signaling pathways activated by the melanocortin-3 receptor". J. Biol. Chem. 269 (18): 13162–6. PMID 8175743. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gantz I, Tashiro T, Barcroft C; et al. (1994). "Localization of the genes encoding the melanocortin-2 (adrenocorticotropic hormone) and melanocortin-3 receptors to chromosomes 18p11.2 and 20q13.2-q13.3 by fluorescence in situ hybridization". Genomics. 18 (1): 166–7. doi:10.1006/geno.1993.1448. PMID 8276410. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yang YK, Ollmann MM, Wilson BD; et al. (1997). "Effects of recombinant agouti-signaling protein on melanocortin action". Mol. Endocrinol. 11 (3): 274–80. doi:10.1210/me.11.3.274. PMID 9058374. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tota MR, Smith TS, Mao C; et al. (1999). "Molecular interaction of Agouti protein and Agouti-related protein with human melanocortin receptors". Biochemistry. 38 (3): 897–904. doi:10.1021/bi9815602. PMID 9893984. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• McNulty JC, Thompson DA, Bolin KA; et al. (2002). "High-resolution NMR structure of the chemically-synthesized melanocortin receptor binding domain AGRP(87-132) of the agouti-related protein". Biochemistry. 40 (51): 15520–7. doi:10.1021/bi0117192. PMID 11747427. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Deloukas P, Matthews LH, Ashurst J; et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lee YS, Poh LK, Loke KY (2002). "A novel melanocortin 3 receptor gene (MC3R) mutation associated with severe obesity". J. Clin. Endocrinol. Metab. 87 (3): 1423–6. doi:10.1210/jc.87.3.1423. PMID 11889220. CS1 maint: Multiple names: authors list (link)
• Qian S, Chen H, Weingarth D; et al. (2002). "Neither agouti-related protein nor neuropeptide Y is critically required for the regulation of energy homeostasis in mice". Mol. Cell. Biol. 22 (14): 5027–35. doi:10.1128/MCB.22.14.5027-5035.2002. PMC 139785 Freely accessible. PMID 12077332. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Boucher N, Lanouette CM, Larose M; et al. (2003). "A +2138InsCAGACC polymorphism of the melanocortin receptor 3 gene is associated in human with fat level and partitioning in interaction with body corpulence". Mol. Med. 8 (3): 158–65. PMC 2039979 Freely accessible. PMID 12142547. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wong J, Love DR, Kyle C; et al. (2002). "Melanocortin-3 receptor gene variants in a Maori kindred with obesity and early onset type 2 diabetes". Diabetes Res. Clin. Pract. 58 (1): 61–71. doi:10.1016/S0168-8227(02)00126-2. PMID 12161058. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241 Freely accessible. PMID 12477932. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rached M, Buronfosse A, Begeot M, Penhoat A (2004). "Inactivation and intracellular retention of the human I183N mutated melanocortin 3 receptor associated with obesity". Biochim. Biophys. Acta. 1689 (3): 229–34. doi:10.1016/j.bbadis.2004.03.009. PMID 15276649. CS1 maint: Multiple names: authors list (link)
• Tao YX, Segaloff DL (2004). "Functional characterization of melanocortin-3 receptor variants identify a loss-of-function mutation involving an amino acid critical for G protein-coupled receptor activation". J. Clin. Endocrinol. Metab. 89 (8): 3936–42. doi:10.1210/jc.2004-0367. PMID 15292330. 
• Lapinsh M, Veiksina S, Uhlén S; et al. (2005). "Proteochemometric mapping of the interaction of organic compounds with melanocortin receptor subtypes". Mol. Pharmacol. 67 (1): 50–9. doi:10.1124/mol.104.002857. PMID 15470082. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 Freely accessible. PMID 15489334. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mandrika I, Petrovska R, Wikberg J (2005). "Melanocortin receptors form constitutive homo- and heterodimers". Biochem. Biophys. Res. Commun. 326 (2): 349–54. doi:10.1016/j.bbrc.2004.11.036. PMID 15582585. CS1 maint: Multiple names: authors list (link)
• de Krom M, de Rijke CE, Hendriks J; et al. (2006). "Mutation analysis of the agouti related protein promoter region and the melanocortin-3 receptor in anorexia nervosa patients". Psychiatr. Genet. 15 (4): 237. doi:10.1097/00041444-200512000-00003. PMID 16314751. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chen M, Aprahamian CJ, Celik A; et al. (2006). "Molecular characterization of human melanocortin-3 receptor ligand-receptor interaction". Biochemistry. 45 (4): 1128–37. doi:10.1021/bi0521792. PMID 16430209. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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