Leukotriene B4 receptor 2

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Leukotriene B4 receptor 2
Identifiers
Symbols	LTB4R2; BLT2; BLTR2; JULF2; KPG_004; NOP9
External IDs	OMIM: 605773 MGI: 1888501 HomoloGene: 10519 IUPHAR: BLT2 GeneCards: LTB4R2 Gene
Gene Ontology Molecular function • receptor activity • leukotriene receptor activity Cellular component • integral to plasma membrane • membrane Biological process • chemotaxis • signal transduction • G-protein coupled receptor protein signaling pathway • negative regulation of adenylate cyclase activity • antimicrobial humoral response Sources: Amigo / EGO
Orthologs
Species	Human	Mouse
Entrez	56413	57260
Ensembl	ENSG00000213906	ENSMUSG00000040432
UniProt	Q9NPC1	Q3KP98
RefSeq (mRNA)	NM_019839	NM_020490
RefSeq (protein)	NP_062813	NP_065236
Location (UCSC)	Chr 14: 24.78 - 24.78 Mb	Chr 14: 54.72 - 54.72 Mb
PubMed search	[1]	[2]

Leukotriene B4 receptor 2 is a protein that in humans is encoded by the LTB4R2 gene.

This is a low-affinity receptor for leukotrienes, especially leukotriene B4. It mediates chemotaxis of granulocytes and macrophages.

See also

• Eicosanoid receptor

External links

• "Leukotriene Receptors: BLT₂". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

Further reading

• Tager AM, Luster AD (2004). "BLT1 and BLT2: the leukotriene B(4) receptors". Prostaglandins Leukot. Essent. Fatty Acids. 69 (2-3): 123–34. doi:10.1016/S0952-3278(03)00073-5. PMID 12895595. 
• Kamohara M, Takasaki J, Matsumoto M; et al. (2000). "Molecular cloning and characterization of another leukotriene B4 receptor". J. Biol. Chem. 275 (35): 27000–4. doi:10.1074/jbc.C000382200. PMID 10889186. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tryselius Y, Nilsson NE, Kotarsky K; et al. (2000). "Cloning and characterization of cDNA encoding a novel human leukotriene B(4) receptor". Biochem. Biophys. Res. Commun. 274 (2): 377–82. doi:10.1006/bbrc.2000.3152. PMID 10913346. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nilsson NE, Tryselius Y, Owman C (2000). "Genomic organization of the leukotriene B(4) receptor locus of human chromosome 14". Biochem. Biophys. Res. Commun. 274 (2): 383–8. doi:10.1006/bbrc.2000.3153. PMID 10913347. CS1 maint: Multiple names: authors list (link)
• Yokomizo T, Kato K, Terawaki K; et al. (2000). "A second leukotriene B(4) receptor, BLT2. A new therapeutic target in inflammation and immunological disorders". J. Exp. Med. 192 (3): 421–32. doi:10.1084/jem.192.3.421. PMC 2193217 Freely accessible. PMID 10934230. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Takeda S, Kadowaki S, Haga T; et al. (2002). "Identification of G protein-coupled receptor genes from the human genome sequence". FEBS Lett. 520 (1-3): 97–101. doi:10.1016/S0014-5793(02)02775-8. PMID 12044878. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241 Freely accessible. PMID 12477932. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hashimoto A, Endo H, Hayashi I; et al. (2003). "Differential expression of leukotriene B4 receptor subtypes (BLT1 and BLT2) in human synovial tissues and synovial fluid leukocytes of patients with rheumatoid arthritis". J. Rheumatol. 30 (8): 1712–8. PMID 12913925. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yoo MH, Song H, Woo CH; et al. (2005). "Role of the BLT2, a leukotriene B4 receptor, in Ras transformation". Oncogene. 23 (57): 9259–68. doi:10.1038/sj.onc.1208151. PMID 15489890. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Qiu H, Johansson AS, Sjöström M; et al. (2006). "Differential induction of BLT receptor expression on human endothelial cells by lipopolysaccharide, cytokines, and leukotriene B4". Proc. Natl. Acad. Sci. U.S.A. 103 (18): 6913–8. doi:10.1073/pnas.0602208103. PMC 1440767 Freely accessible. PMID 16624877. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lundeen KA, Sun B, Karlsson L, Fourie AM (2006). "Leukotriene B4 receptors BLT1 and BLT2: expression and function in human and murine mast cells". J. Immunol. 177 (5): 3439–47. PMID 16920986. CS1 maint: Multiple names: authors list (link)

External links

• IUPHAR GPCR Database - Leukotriene receptors
• MeSH LTB4R2+protein,+human
• MeSH Receptors,+Leukotriene+B4

This article incorporates text from the United States National Library of Medicine, which is in the public domain.