GPR6

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G protein-coupled receptor 6
Identifiers
Symbols	GPR6;
External IDs	OMIM: 600553 MGI: 2155249 HomoloGene: 38026 IUPHAR: GPR6 GeneCards: GPR6 Gene
Gene Ontology Molecular function • lysosphingolipid and lysophosphatidic acid receptor activity • receptor activity Cellular component • integral to plasma membrane • membrane Biological process • signal transduction • G-protein coupled receptor protein signaling pathway • elevation of cytosolic calcium ion concentration Sources: Amigo / EGO
RNA expression pattern
250px
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2830	140741
Ensembl	ENSG00000146360	ENSMUSG00000046922
UniProt	P46095	Q2M2N8
RefSeq (mRNA)	NM_005284	NM_199058
RefSeq (protein)	NP_005275	NP_951013
Location (UCSC)	Chr 6: 110.41 - 110.41 Mb	Chr 10: 40.76 - 40.76 Mb
PubMed search	[1]	[2]

G protein-coupled receptor 6, also known as GPR6, is a protein which in humans is encoded by the GPR6 gene.

Function

GPR6 is a member of the G protein-coupled receptor family of transmembrane receptors. It has been reported that GPR6 is both constitutively active but in addition is further activated by sphingosine-1-phosphate.

GPR6 up-regulates cyclic AMP levels and promotes neurite outgrowth.

See also

• Lysophospholipid receptor

Further reading

• Heiber M, Docherty JM, Shah G; et al. (1995). "Isolation of three novel human genes encoding G protein-coupled receptors". DNA Cell Biol. 14 (1): 25–35. doi:10.1089/dna.1995.14.25. PMID 7832990. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Song ZH, Modi W, Bonner TI (1996). "Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors". Genomics. 28 (2): 347–9. doi:10.1006/geno.1995.1154. PMID 8530049. CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241 Freely accessible. PMID 12477932. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Uhlenbrock K, Huber J, Ardati A; et al. (2003). "Fluid shear stress differentially regulates gpr3, gpr6, and gpr12 expression in human umbilical vein endothelial cells". Cell. Physiol. Biochem. 13 (2): 75–84. doi:10.1159/000070251. PMID 12649592. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mungall AJ, Palmer SA, Sims SK; et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 Freely accessible. PMID 15489334. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

External links

• "GPR6". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.