GPR63
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| G protein-coupled receptor 63 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | GPR63; PSP24(beta); PSP24B | ||||||||||||
| External IDs | OMIM: 606915 MGI: 2135884 HomoloGene: 12759 IUPHAR: GPR63 GeneCards: GPR63 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
| 250px | |||||||||||||
| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 81491 | 81006 | |||||||||||
| Ensembl | ENSG00000112218 | ENSMUSG00000040372 | |||||||||||
| UniProt | Q9BZJ6 | Q8BZ93 | |||||||||||
| RefSeq (mRNA) | NM_030784 | NM_030733 | |||||||||||
| RefSeq (protein) | NP_110411 | NP_109658 | |||||||||||
| Location (UCSC) | Chr 6: 97.35 - 97.39 Mb | Chr 4: 25.06 - 25.1 Mb | |||||||||||
| PubMed search | [1] | [2] | |||||||||||
Probable G-protein coupled receptor 63 is a protein that in humans is encoded by the GPR63 gene.[1]
G protein-coupled receptors (GPCRs, or GPRs) contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.[supplied by OMIM][1]
References
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<references />, or <references group="..." />Further reading
- Kawasawa Y, Kume K, Nakade S; et al. (2000). "Brain-specific expression of novel G-protein-coupled receptors, with homologies to Xenopus PSP24 and human GPR45". Biochem. Biophys. Res. Commun. 276 (3): 952–6. doi:10.1006/bbrc.2000.3569. PMID 11027574.
- Kawasawa Y, Kume K, Izumi T, Shimizu T (2000). "Mammalian PSP24s (alpha and beta isoforms) are not responsive to lysophosphatidic acid in mammalian expression systems". Biochem. Biophys. Res. Commun. 276 (3): 957–64. doi:10.1006/bbrc.2000.3570. PMID 11027575.
- Lee DK, George SR, Cheng R; et al. (2001). "Identification of four novel human G protein-coupled receptors expressed in the brain". Brain Res. Mol. Brain Res. 86 (1-2): 13–22. doi:10.1016/S0169-328X(00)00242-4. PMID 11165367.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241 Freely accessible. PMID 12477932.
- Niedernberg A, Tunaru S, Blaukat A; et al. (2004). "Sphingosine 1-phosphate and dioleoylphosphatidic acid are low affinity agonists for the orphan receptor GPR63". Cell. Signal. 15 (4): 435–46. doi:10.1016/S0898-6568(02)00119-5. PMID 12618218.
- Mungall AJ, Palmer SA, Sims SK; et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 Freely accessible. PMID 15489334.
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