Melanin-concentrating hormone receptor 2

edit

Melanin-concentrating hormone receptor 2
Identifiers
Symbols	MCHR2; MCH2; GPR145; MCH2R; SLT
External IDs	OMIM: 606111 HomoloGene: 50004 IUPHAR: MCH2 GeneCards: MCHR2 Gene
Gene Ontology Molecular function • rhodopsin-like receptor activity • receptor activity Cellular component • membrane • integral to membrane Biological process • signal transduction • G-protein coupled receptor protein signaling pathway Sources: Amigo / EGO
Orthologs
Species	Human	Mouse
Entrez	84539	n/a
Ensembl	ENSG00000152034	n/a
UniProt	Q969V1	n/a
RefSeq (mRNA)	NM_001040179	n/a
RefSeq (protein)	NP_001035269	n/a
Location (UCSC)	Chr 6: 100.47 - 100.55 Mb	n/a
PubMed search	[1]	n/a

Melanin-concentrating hormone receptor 2, also known as MCH₂, is both a human gene, and the receptor that it codes for. MCH₂ is found in humans, dogs, ferrets, and some other primates and carnivores, but is not found in mice or rats. This has delayed research into the receptor as a therapeutic target, due to most early pharmaceutical research usually being conducted in small mammals such as mice, rats or rabbits which lack the MCH₂ gene and its receptor product.

See also

• Melanin-concentrating hormone receptor

External links

• "Melanin-Concentrating Hormone Receptors: MCH₂". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

Further reading

• Hill J, Duckworth M, Murdock P; et al. (2001). "Molecular cloning and functional characterization of MCH2, a novel human MCH receptor". J. Biol. Chem. 276 (23): 20125–9. doi:10.1074/jbc.M102068200. PMID 11274220. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mori M, Harada M, Terao Y; et al. (2001). "Cloning of a novel G protein-coupled receptor, SLT, a subtype of the melanin-concentrating hormone receptor". Biochem. Biophys. Res. Commun. 283 (5): 1013–8. doi:10.1006/bbrc.2001.4893. PMID 11355873. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sailer AW, Sano H, Zeng Z; et al. (2001). "Identification and characterization of a second melanin-concentrating hormone receptor, MCH-2R". Proc. Natl. Acad. Sci. U.S.A. 98 (13): 7564–9. doi:10.1073/pnas.121170598. PMC 34708 Freely accessible. PMID 11404457. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• An S, Cutler G, Zhao JJ; et al. (2001). "Identification and characterization of a melanin-concentrating hormone receptor". Proc. Natl. Acad. Sci. U.S.A. 98 (13): 7576–81. doi:10.1073/pnas.131200698. PMC 34710 Freely accessible. PMID 11416225. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wang S, Behan J, O'Neill K; et al. (2001). "Identification and pharmacological characterization of a novel human melanin-concentrating hormone receptor, mch-r2". J. Biol. Chem. 276 (37): 34664–70. doi:10.1074/jbc.M102601200. PMID 11459838. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bednarek MA, Feighner SD, Hreniuk DL; et al. (2001). "Short segment of human melanin-concentrating hormone that is sufficient for full activation of human melanin-concentrating hormone receptors 1 and 2". Biochemistry. 40 (31): 9379–86. doi:10.1021/bi010867p. PMID 11478907. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bednarek MA, Tan C, Hreniuk DL; et al. (2002). "Synthesis and biological evaluation in vitro of a selective, high potency peptide agonist of human melanin-concentrating hormone action at human melanin-concentrating hormone receptor 1". J. Biol. Chem. 277 (16): 13821–6. doi:10.1074/jbc.M200563200. PMID 11839762. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Audinot V, Lahaye C, Suply T; et al. (2002). "SVK14 cells express an MCH binding site different from the MCH1 or MCH2 receptor". Biochem. Biophys. Res. Commun. 295 (4): 841–8. doi:10.1016/S0006-291X(02)00763-5. PMID 12127971. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241 Freely accessible. PMID 12477932. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Logan DW, Bryson-Richardson RJ, Pagán KE; et al. (2003). "The structure and evolution of the melanocortin and MCH receptors in fish and mammals". Genomics. 81 (2): 184–91. doi:10.1016/S0888-7543(02)00037-X. PMID 12620396. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mungall AJ, Palmer SA, Sims SK; et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Vitale RM, Pedone C, De Benedetti PG, Fanelli F (2004). "Structural features of the inactive and active states of the melanin-concentrating hormone receptors: insights from molecular simulations". Proteins. 56 (3): 430–48. doi:10.1002/prot.20125. PMID 15229878. CS1 maint: Multiple names: authors list (link)
• Hawes BE, Green B, O'Neill K; et al. (2004). "Identification and characterization of single-nucleotide polymorphisms in MCH-R1 and MCH-R2". Obes. Res. 12 (8): 1327–34. doi:10.1038/oby.2004.167. PMID 15340116. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 Freely accessible. PMID 15489334. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

sr:Melanin-koncentrirajući hormonski receptor 2