Cysteinyl leukotriene receptor 1

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Cysteinyl leukotriene receptor 1
Identifiers
Symbols	CYSLTR1; CYSLT1; CYSLT1R; CYSLTR; HG55; HMTMF81; MGC46139
External IDs	OMIM: 300201 MGI: 1926218 HomoloGene: 4837 IUPHAR: CysLT1 GeneCards: CYSLTR1 Gene
Gene Ontology Molecular function • receptor activity • leukotriene receptor activity Cellular component • membrane fraction • integral to plasma membrane • membrane Biological process • defense response • G-protein coupled receptor protein signaling pathway • elevation of cytosolic calcium ion concentration • respiratory gaseous exchange Sources: Amigo / EGO
Orthologs
Species	Human	Mouse
Entrez	10800	58861
Ensembl	ENSG00000173198	ENSMUSG00000052821
UniProt	Q9Y271	Q544P1
RefSeq (mRNA)	NM_006639	NM_021476
RefSeq (protein)	NP_006630	NP_067451
Location (UCSC)	Chr X: 77.41 - 77.47 Mb	Chr X: 102.78 - 102.78 Mb
PubMed search	[1]	[2]

Cysteinyl leukotriene receptor 1 is a protein that in humans is encoded by the CYSLTR1 gene.

The cysteinyl leukotrienes LTC4, LTD4, and LTE4 are important mediators of human bronchial asthma. Pharmacologic studies have determined that cysteinyl leukotrienes activate at least 2 receptors, the protein encoded by this gene and CYSLTR2. This encoded receptor is a member of the superfamily of G protein-coupled receptors. Activation of this receptor by LTD4 results in contraction and proliferation of smooth muscle, oedema, eosinophil migration and damage to the mucus layer in the lung.

See also

• Eicosanoid receptor

External links

• "Leukotriene Receptors: CysLT₁". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

Further reading

• Gronert K, Martinsson-Niskanen T, Ravasi S; et al. (2001). "Selectivity of recombinant human leukotriene D(4), leukotriene B(4), and lipoxin A(4) receptors with aspirin-triggered 15-epi-LXA(4) and regulation of vascular and inflammatory responses". Am. J. Pathol. 158 (1): 3–9. PMC 1850279 Freely accessible. PMID 11141472. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sjöström M, Jakobsson PJ, Heimburger M; et al. (2001). "Human umbilical vein endothelial cells generate leukotriene C4 via microsomal glutathione S-transferase type 2 and express the CysLT(1) receptor". Eur. J. Biochem. 268 (9): 2578–86. doi:10.1046/j.1432-1327.2001.02142.x. PMID 11322876. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mellor EA, Maekawa A, Austen KF, Boyce JA (2001). "Cysteinyl leukotriene receptor 1 is also a pyrimidinergic receptor and is expressed by human mast cells". Proc. Natl. Acad. Sci. U.S.A. 98 (14): 7964–9. doi:10.1073/pnas.141221498. PMC 35451 Freely accessible. PMID 11438743. CS1 maint: Multiple names: authors list (link)
• Mita H, Hasegawa M, Saito H, Akiyama K (2002). "Levels of cysteinyl leukotriene receptor mRNA in human peripheral leucocytes: significantly higher expression of cysteinyl leukotriene receptor 2 mRNA in eosinophils". Clin. Exp. Allergy. 31 (11): 1714–23. doi:10.1046/j.1365-2222.2001.01184.x. PMID 11696047. CS1 maint: Multiple names: authors list (link)
• Shirasaki H, Kanaizumi E, Watanabe K; et al. (2003). "Expression and localization of the cysteinyl leukotriene 1 receptor in human nasal mucosa". Clin. Exp. Allergy. 32 (7): 1007–12. doi:10.1046/j.1365-2222.2002.01425.x. PMID 12100046. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ohshima N, Nagase H, Koshino T; et al. (2002). "A functional study on CysLT(1) receptors in human eosinophils". Int. Arch. Allergy Immunol. 129 (1): 67–75. doi:10.1159/000065175. PMID 12373000. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241 Freely accessible. PMID 12477932. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ohd JF, Nielsen CK, Campbell J; et al. (2003). "Expression of the leukotriene D4 receptor CysLT1, COX-2, and other cell survival factors in colorectal adenocarcinomas". Gastroenterology. 124 (1): 57–70. doi:10.1053/gast.2003.50011. PMID 12512030. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chibana K, Ishii Y, Asakura T, Fukuda T (2003). "Up-regulation of cysteinyl leukotriene 1 receptor by IL-13 enables human lung fibroblasts to respond to leukotriene C4 and produce eotaxin". J. Immunol. 170 (8): 4290–5. PMID 12682264. CS1 maint: Multiple names: authors list (link)
• Espinosa K, Bossé Y, Stankova J, Rola-Pleszczynski M (2003). "CysLT1 receptor upregulation by TGF-beta and IL-13 is associated with bronchial smooth muscle cell proliferation in response to LTD4". J. Allergy Clin. Immunol. 111 (5): 1032–40. doi:10.1067/mai.2003.1451. PMID 12743568. CS1 maint: Multiple names: authors list (link)
• Walch L, Norel X, Gascard JP, Brink C (2003). "Arachidonic acid inhibits cysteinyl-leukotriene receptor activation in human pulmonary vessels". Adv. Exp. Med. Biol. 525: 75–9. PMID 12751740. CS1 maint: Multiple names: authors list (link)
• Nielsen CK, Ohd JF, Wikström K; et al. (2003). "The leukotriene receptor CysLT1 and 5-lipoxygenase are upregulated in colon cancer". Adv. Exp. Med. Biol. 525: 201–4. PMID 12751768. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mechiche H, Naline E, Candenas L; et al. (2003). "Effects of cysteinyl leukotrienes in small human bronchus and antagonist activity of montelukast and its metabolites". Clin. Exp. Allergy. 33 (7): 887–94. doi:10.1046/j.1365-2222.2003.01696.x. PMID 12859443. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yang G, Haczku A, Chen H; et al. (2004). "Transgenic smooth muscle expression of the human CysLT1 receptor induces enhanced responsiveness of murine airways to leukotriene D4". Am. J. Physiol. Lung Cell Mol. Physiol. 286 (5): L992–1001. doi:10.1152/ajplung.00367.2003. PMID 15064240. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 Freely accessible. PMID 15489334. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Naik S, Billington CK, Pascual RM; et al. (2005). "Regulation of cysteinyl leukotriene type 1 receptor internalization and signaling". J. Biol. Chem. 280 (10): 8722–32. doi:10.1074/jbc.M413014200. PMID 15590629. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Corrigan C, Mallett K, Ying S; et al. (2005). "Expression of the cysteinyl leukotriene receptors cysLT(1) and cysLT(2) in aspirin-sensitive and aspirin-tolerant chronic rhinosinusitis". J. Allergy Clin. Immunol. 115 (2): 316–22. doi:10.1016/j.jaci.2004.10.051. PMID 15696087. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

pt:CysLT1