Prostaglandin D2 receptor

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Prostaglandin D2 receptor (DP)
Identifiers
Symbols	PTGDR; AS1; ASRT1; DP; MGC49004
External IDs	OMIM: 604687 MGI: 102966 HomoloGene: 736 IUPHAR: DP1 GeneCards: PTGDR Gene
Gene Ontology Molecular function • rhodopsin-like receptor activity • prostaglandin J receptor activity • receptor activity • prostaglandin D receptor activity • thromboxane receptor activity Cellular component • membrane • integral to membrane Biological process • signal transduction • G-protein coupled receptor protein signaling pathway Sources: Amigo / EGO
RNA expression pattern
250px
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5729	19214
Ensembl	ENSG00000168229	ENSMUSG00000071489
UniProt	Q13258	Q8CCM3
RefSeq (mRNA)	NM_000953	NM_008962
RefSeq (protein)	NP_000944	NP_032988
Location (UCSC)	Chr 14: 51.8 - 51.81 Mb	Chr 14: 43.77 - 43.78 Mb
PubMed search	[1]	[2]

Prostaglandin D₂ receptor (DP₁) is a G-protein coupled receptor, encoded by the PTGDR gene, for prostaglandin D₂.

Mechanism

DP₁ is a G-protein-coupled receptor. Its activity is mainly mediated by G-S proteins that stimulate adenylate cyclase resulting in an elevation of intracellular cAMP and Ca²⁺.

Function

Knockout studies in mice suggest that the ligand of this receptor, prostaglandin D₂ (PGD₂), functions as a mast cell-derived mediator to trigger asthmatic responses. It also causes vasodilation

See also

• Eicosanoid receptor

External links

• "Prostanoid Receptors: DP₁". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

Further reading

• Boyce JA (2004). "The role of mast cells in asthma". Prostaglandins Leukot. Essent. Fatty Acids. 69 (2-3): 195–205. doi:10.1016/S0952-3278(03)00081-4. PMID 12895603. 
• Chiba T, Kanda A, Ueki S; et al. (2007). "Possible novel receptor for PGD2 on human bronchial epithelial cells". Int. Arch. Allergy Immunol. 143 Suppl 1: 23–7. doi:10.1159/000101400. PMID 17541272. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Senior J, Sangha R, Baxter GS; et al. (1992). "In vitro characterization of prostanoid FP-, DP-, IP- and TP-receptors on the non-pregnant human myometrium". Br. J. Pharmacol. 107 (1): 215–21. PMC 1907618 Freely accessible. PMID 1422574. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Boie Y, Sawyer N, Slipetz DM; et al. (1995). "Molecular cloning and characterization of the human prostanoid DP receptor". J. Biol. Chem. 270 (32): 18910–6. doi:10.1074/jbc.270.32.18910. PMID 7642548. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ishikawa TO, Tamai Y, Rochelle JM; et al. (1997). "Mapping of the genes encoding mouse prostaglandin D, E, and F and prostacyclin receptors". Genomics. 32 (2): 285–8. doi:10.1006/geno.1996.0118. PMID 8833158. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kobayashi T, Ushikubi F, Narumiya S (2000). "Amino acid residues conferring ligand binding properties of prostaglandin I and prostaglandin D receptors. Identification by site-directed mutagenesis". J. Biol. Chem. 275 (32): 24294–303. doi:10.1074/jbc.M002437200. PMID 10827082. CS1 maint: Multiple names: authors list (link)
• Wright DH, Ford-Hutchinson AW, Chadee K, Metters KM (2001). "The human prostanoid DP receptor stimulates mucin secretion in LS174T cells". Br. J. Pharmacol. 131 (8): 1537–45. doi:10.1038/sj.bjp.0703688. PMC 1572485 Freely accessible. PMID 11139429. CS1 maint: Multiple names: authors list (link)
• Gervais FG, Cruz RP, Chateauneuf A; et al. (2002). "Selective modulation of chemokinesis, degranulation, and apoptosis in eosinophils through the PGD2 receptors CRTH2 and DP". J. Allergy Clin. Immunol. 108 (6): 982–8. doi:10.1067/mai.2001.119919. PMID 11742277. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Noguchi E, Shibasaki M, Kamioka M; et al. (2002). "New polymorphisms of haematopoietic prostaglandin D synthase and human prostanoid DP receptor genes". Clin. Exp. Allergy. 32 (1): 93–6. doi:10.1046/j.0022-0477.2001.01261.x. PMID 12002745. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hakonarson H, Bjornsdottir US, Halapi E; et al. (2002). "A major susceptibility gene for asthma maps to chromosome 14q24". Am. J. Hum. Genet. 71 (3): 483–91. doi:10.1086/342205. PMC 379187 Freely accessible. PMID 12119603. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Iwasaki M, Nagata K, Takano S; et al. (2002). "Association of a new-type prostaglandin D2 receptor CRTH2 with circulating T helper 2 cells in patients with atopic dermatitis". J. Invest. Dermatol. 119 (3): 609–16. doi:10.1046/j.1523-1747.2002.01862.x. PMID 12230502. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241 Freely accessible. PMID 12477932. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Moreland RB, Nehra A, Kim NN; et al. (2003). "Expression of functional prostaglandin D (DP) receptors in human corpus cavernosum smooth muscle". Int. J. Impot. Res. 14 (6): 446–52. doi:10.1038/sj.ijir.3900900. PMID 12494276. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Faveeuw C, Gosset P, Bureau F; et al. (2003). "Prostaglandin D2 inhibits the production of interleukin-12 in murine dendritic cells through multiple signaling pathways". Eur. J. Immunol. 33 (4): 889–98. doi:10.1002/eji.200323330. PMID 12672054. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Angeli V, Staumont D, Charbonnier AS; et al. (2004). "Activation of the D prostanoid receptor 1 regulates immune and skin allergic responses". J. Immunol. 172 (6): 3822–9. PMID 15004188. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 Freely accessible. PMID 15489334. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Oguma T, Palmer LJ, Birben E; et al. (2004). "Role of prostanoid DP receptor variants in susceptibility to asthma". N. Engl. J. Med. 351 (17): 1752–63. doi:10.1056/NEJMoa031785. PMID 15496624. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Spik I, Brénuchon C, Angéli V; et al. (2005). "Activation of the prostaglandin D2 receptor DP2/CRTH2 increases allergic inflammation in mouse". J. Immunol. 174 (6): 3703–8. PMID 15749909. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hirano Y, Shichijo M, Deguchi M; et al. (2007). "Synergistic effect of PGD2 via prostanoid DP receptor on TNF-alpha-induced production of MCP-1 and IL-8 in human monocytic THP-1 cells". Eur. J. Pharmacol. 560 (1): 81–8. doi:10.1016/j.ejphar.2007.01.003. PMID 17307163. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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