Formyl peptide receptor 1

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Formyl peptide receptor 1
Identifiers
SymbolsFPR1; FMLP; FPR
External IDsOMIM: 136537 MGI: 107443 HomoloGene: 20466 IUPHAR: FPR1 GeneCards: FPR1 Gene
RNA expression pattern
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More reference expression data
Orthologs
SpeciesHumanMouse
Entrez235714293
EnsemblENSG00000171051ENSMUSG00000045551
UniProtP21462Q3UV01
RefSeq (mRNA)NM_002029NM_013521
RefSeq (protein)NP_002020NP_038549
Location (UCSC)Chr 19:
56.94 - 56.95 Mb		Chr 17:
17.58 - 17.59 Mb
PubMed search[1][2]

fMet-Leu-Phe receptor also known as the N-formyl peptide receptor is a protein that in humans is encoded by the FPR1 gene.[1][2][3]

See also

References

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Further reading

  • Graves V, Gabig T, McCarthy L; et al. (1992). "Simultaneous mobilization of Mac-1 (CD11b/CD18) and formyl peptide chemoattractant receptors in human neutrophils". Blood. 80 (3): 776–87. PMID 1322204. 
  • Murphy PM, Ozçelik T, Kenney RT; et al. (1992). "A structural homologue of the N-formyl peptide receptor. Characterization and chromosome mapping of a peptide chemoattractant receptor family". J. Biol. Chem. 267 (11): 7637–43. PMID 1373134. 
  • Perez HD, Holmes R, Kelly E; et al. (1992). "Cloning of the gene coding for a human receptor for formyl peptides. Characterization of a promoter region and evidence for polymorphic expression". Biochemistry. 31 (46): 11595–9. doi:10.1021/bi00161a044. PMID 1445895. 
  • Bao L, Gerard NP, Eddy RL; et al. (1992). "Mapping of genes for the human C5a receptor (C5AR), human FMLP receptor (FPR), and two FMLP receptor homologue orphan receptors (FPRH1, FPRH2) to chromosome 19". Genomics. 13 (2): 437–40. doi:10.1016/0888-7543(92)90265-T. PMID 1612600. 
  • Murphy PM, McDermott D (1991). "Functional expression of the human formyl peptide receptor in Xenopus oocytes requires a complementary human factor". J. Biol. Chem. 266 (19): 12560–7. PMID 1712023. 
  • Boulay F, Tardif M, Brouchon L, Vignais P (1991). "The human N-formylpeptide receptor. Characterization of two cDNA isolates and evidence for a new subfamily of G-protein-coupled receptors". Biochemistry. 29 (50): 11123–33. doi:10.1021/bi00502a016. PMID 2176894. 
  • Wahl SM, Allen JB, Gartner S; et al. (1989). "HIV-1 and its envelope glycoprotein down-regulate chemotactic ligand receptors and chemotactic function of peripheral blood monocytes". J. Immunol. 142 (10): 3553–9. PMID 2541200. 
  • Jesaitis AJ, Naemura JR, Painter RG; et al. (1983). "Intracellular localization of N-formyl chemotactic receptor and Mg2+ dependent ATPase in human granulocytes". Biochim. Biophys. Acta. 719 (3): 556–68. PMID 6129903. 
  • Prossnitz ER, Kim CM, Benovic JL, Ye RD (1995). "Phosphorylation of the N-formyl peptide receptor carboxyl terminus by the G protein-coupled receptor kinase, GRK2". J. Biol. Chem. 270 (3): 1130–7. doi:10.1074/jbc.270.3.1130. PMID 7836371. 
  • Klotz KN, Jesaitis AJ (1994). "Physical coupling of N-formyl peptide chemoattractant receptors to G protein is unaffected by desensitization". Biochem. Pharmacol. 48 (6): 1297–300. doi:10.1016/0006-2952(94)90168-6. PMID 7945424. 
  • Bommakanti RK, Dratz EA, Siemsen DW, Jesaitis AJ (1994). "Characterization of complex formation between Gi2 and octyl glucoside solubilized neutrophil N-formyl peptide chemoattractant receptor by sedimentation velocity". Biochim. Biophys. Acta. 1209 (1): 69–76. PMID 7947984. 
  • Murphy PM, Tiffany HL, McDermott D, Ahuja SK (1993). "Sequence and organization of the human N-formyl peptide receptor-encoding gene". Gene. 133 (2): 285–90. doi:10.1016/0378-1119(93)90653-K. PMID 8224916. 
  • Jesaitis AJ, Erickson RW, Klotz KN; et al. (1993). "Functional molecular complexes of human N-formyl chemoattractant receptors and actin". J. Immunol. 151 (10): 5653–65. PMID 8228254. 
  • Särndahl E, Bokoch GM, Boulay F; et al. (1996). "Direct or C5a-induced activation of heterotrimeric Gi2 proteins in human neutrophils is associated with interaction between formyl peptide receptors and the cytoskeleton". J. Biol. Chem. 271 (25): 15267–71. doi:10.1074/jbc.271.25.15267. PMID 8663057. 
  • Maestes DC, Potter RM, Prossnitz ER (1999). "Differential phosphorylation paradigms dictate desensitization and internalization of the N-formyl peptide receptor". J. Biol. Chem. 274 (42): 29791–5. doi:10.1074/jbc.274.42.29791. PMID 10514456. 
  • Liang TS, Wang JM, Murphy PM, Gao JL (2000). "Serum amyloid A is a chemotactic agonist at FPR2, a low-affinity N-formylpeptide receptor on mouse neutrophils". Biochem. Biophys. Res. Commun. 270 (2): 331–5. doi:10.1006/bbrc.2000.2416. PMID 10753626. 
  • Luu NT, Rainger GE, Nash GB (2000). "Differential ability of exogenous chemotactic agents to disrupt transendothelial migration of flowing neutrophils". J. Immunol. 164 (11): 5961–9. PMID 10820279. 
  • Bennett TA, Maestas DC, Prossnitz ER (2000). "Arrestin binding to the G protein-coupled N-formyl peptide receptor is regulated by the conserved "DRY" sequence". J. Biol. Chem. 275 (32): 24590–4. doi:10.1074/jbc.C000314200. PMID 10823817. 
  • Ayala JM, Goyal S, Liverton NJ; et al. (2000). "Serum-induced monocyte differentiation and monocyte chemotaxis are regulated by the p38 MAP kinase signal transduction pathway". J. Leukoc. Biol. 67 (6): 869–75. PMID 10857861. 
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Class A: Rhodopsin like
α1 (A, B, D) · α2 (A, B, C) · β1 · β2 · β3
Adenosine (A1, A2A, A2B, A3) · P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
(all but 5-HT3) 5-HT1 (A, B, D, E, F) · 5-HT2 (A, B, C) · 5-HT (4, 5A, 6, 7)
Other
Acetylcholine (M1, M2, M3, M4, M5) · Dopamine (D1, D2, D3, D4, D5) · Histamine (H1, H2, H3, H4) · Melatonin (1A, 1B, 1C) · TAAR (1, 2, 3, 5, 6, 8, 9)
Metabolites and
signaling molecules
CysLT (1, 2) · LTB4 (1, 2) · FPRL1 · OXE · Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) · Prostacyclin · Thromboxane
Other
Bile acid · Cannabinoid (CB1, CB2, GPR (18, 55, 119)) · EBI2 · Estrogen · Free fatty acid (1, 2, 3, 4) · Lactate  · Lysophosphatidic acid (1, 2, 3, 4, 5, 6)  · Lysophospholipid (1, 2, 3, 4, 5, 6, 7, 8) · Niacin (1, 2) · Oxoglutarate · PAF · Sphingosine-1-phosphate (1, 2, 3, 4, 5) · Succinate
Peptide
B/W (1, 2) · FF (1, 2) · S · Y (1, 2, 4, 5) · Neuromedin (B, U (1, 2)) · Neurotensin (1, 2)
Other
Miscellaneous
GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Other
Class B: Secretin like
GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Other
Class C: Metabotropic
glutamate / pheromone
TAS1R (1, 2, 3) · TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Other
Class F:
Frizzled / Smoothened
Frizzled
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Smoothened
  1. ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
  2. ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
  3. ↑ "Entrez Gene: FPR1 formyl peptide receptor 1". 
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