Free fatty acid receptor 2
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| Free fatty acid receptor 2 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | FFAR2; FFA2R; GPR43 | ||||||||||||
| External IDs | OMIM: 603823 MGI: 2441731 HomoloGene: 74309 IUPHAR: FFA2 GeneCards: FFAR2 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
| 250px | |||||||||||||
| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 2867 | 233079 | |||||||||||
| Ensembl | ENSG00000126262 | ENSMUSG00000051314 | |||||||||||
| UniProt | O15552 | Q8VCK6 | |||||||||||
| RefSeq (mRNA) | NM_005306 | NM_146187 | |||||||||||
| RefSeq (protein) | NP_005297 | NP_666299 | |||||||||||
| Location (UCSC) | Chr 19: 40.63 - 40.63 Mb | Chr 7: 30.53 - 30.53 Mb | |||||||||||
| PubMed search | [1] | [2] | |||||||||||
Free fatty acid receptor 2 (FFA2) is a G-protein coupled receptor encoded by the FFAR2 gene.[1]
See also
References
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- "Free Fatty Acid Receptors: FFA2". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
Further reading
- Brown AJ, Jupe S, Briscoe CP (2005). "A family of fatty acid binding receptors". DNA Cell Biol. 24 (1): 54–61. doi:10.1089/dna.2005.24.54. PMID 15684720.
- Sawzdargo M, George SR, Nguyen T; et al. (1997). "A cluster of four novel human G protein-coupled receptor genes occurring in close proximity to CD22 gene on chromosome 19q13.1". Biochem. Biophys. Res. Commun. 239 (2): 543–7. doi:10.1006/bbrc.1997.7513. PMID 9344866.
- Senga T, Iwamoto S, Yoshida T; et al. (2003). "LSSIG is a novel murine leukocyte-specific GPCR that is induced by the activation of STAT3". Blood. 101 (3): 1185–7. doi:10.1182/blood-2002-06-1881. PMID 12393494.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241 Freely accessible. PMID 12477932.
- Brown AJ, Goldsworthy SM, Barnes AA; et al. (2003). "The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids". J. Biol. Chem. 278 (13): 11312–9. doi:10.1074/jbc.M211609200. PMID 12496283.
- Nilsson NE, Kotarsky K, Owman C, Olde B (2003). "Identification of a free fatty acid receptor, FFA2R, expressed on leukocytes and activated by short-chain fatty acids". Biochem. Biophys. Res. Commun. 303 (4): 1047–52. doi:10.1016/S0006-291X(03)00488-1. PMID 12684041.
- Le Poul E, Loison C, Struyf S; et al. (2003). "Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation". J. Biol. Chem. 278 (28): 25481–9. doi:10.1074/jbc.M301403200. PMID 12711604.
- Grimwood J, Gordon LA, Olsen A; et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 Freely accessible. PMID 15489334.
- Yonezawa T, Kobayashi Y, Obara Y (2007). "Short-chain fatty acids induce acute phosphorylation of the p38 mitogen-activated protein kinase/heat shock protein 27 pathway via GPR43 in the MCF-7 human breast cancer cell line". Cell. Signal. 19 (1): 185–93. doi:10.1016/j.cellsig.2006.06.004. PMID 16887331.
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