Neuropeptides B/W receptor 2
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| Neuropeptides B/W receptor 2 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | NPBWR2; GPR8 | ||||||||||||
| External IDs | OMIM: 600731 HomoloGene: 48336 IUPHAR: NPBW2 GeneCards: NPBWR2 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
| 250px | |||||||||||||
| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 2832 | n/a | |||||||||||
| Ensembl | ENSG00000125522 | n/a | |||||||||||
| UniProt | P48146 | n/a | |||||||||||
| RefSeq (mRNA) | NM_005286 | n/a | |||||||||||
| RefSeq (protein) | NP_005277 | n/a | |||||||||||
| Location (UCSC) | Chr 20: 62.21 - 62.21 Mb | n/a | |||||||||||
| PubMed search | [1] | n/a | |||||||||||
Neuropeptides B/W receptor 2, also known as NPBW2, is a human protein encoded by the NPBWR2 gene.[1]
The protein encoded by this gene is an integral membrane protein and G protein-coupled receptor. The encoded protein is similar in sequence to another G protein-coupled receptor (GPR7), and it is structurally similar to opioid and somatostatin receptors. This protein binds neuropeptides B and W. This gene is intronless and is expressed primarily in the frontal cortex of the brain.[1]
See also
References
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<references />, or <references group="..." />External links
- "Neuropeptide B/W Receptors: NPBW2". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
Further reading
- O'Dowd BF, Scheideler MA, Nguyen T; et al. (1995). "The cloning and chromosomal mapping of two novel human opioid-somatostatin-like receptor genes, GPR7 and GPR8, expressed in discrete areas of the brain". Genomics. 28 (1): 84–91. doi:10.1006/geno.1995.1109. PMID 7590751.
- Deloukas P, Matthews LH, Ashurst J; et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
- Shimomura Y, Harada M, Goto M; et al. (2002). "Identification of neuropeptide W as the endogenous ligand for orphan G-protein-coupled receptors GPR7 and GPR8". J. Biol. Chem. 277 (39): 35826–32. doi:10.1074/jbc.M205337200. PMID 12130646.
- Brezillon S, Lannoy V, Franssen JD; et al. (2003). "Identification of natural ligands for the orphan G protein-coupled receptors GPR7 and GPR8". J. Biol. Chem. 278 (2): 776–83. doi:10.1074/jbc.M206396200. PMID 12401809.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241 Freely accessible. PMID 12477932.
- Tanaka H, Yoshida T, Miyamoto N; et al. (2003). "Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8". Proc. Natl. Acad. Sci. U.S.A. 100 (10): 6251–6. doi:10.1073/pnas.0837789100. PMC 156358 Freely accessible. PMID 12719537.
- Mazzocchi G, Rebuffat P, Ziolkowska A; et al. (2005). "G protein receptors 7 and 8 are expressed in human adrenocortical cells, and their endogenous ligands neuropeptides B and w enhance cortisol secretion by activating adenylate cyclase- and phospholipase C-dependent signaling cascades". J. Clin. Endocrinol. Metab. 90 (6): 3466–71. doi:10.1210/jc.2004-2132. PMID 15797961.
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
