Neuropeptide Y receptor Y1

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Neuropeptide Y receptor Y1
Identifiers
Symbols	NPY1R; NPYR
External IDs	OMIM: 162641 MGI: 104963 HomoloGene: 700 IUPHAR: Y1 GeneCards: NPY1R Gene
Gene Ontology Molecular function • rhodopsin-like receptor activity • peptide YY receptor activity • pancreatic polypeptide receptor activity • receptor activity • neuropeptide Y receptor activity • protein binding Cellular component • integral to plasma membrane • membrane • integral to membrane Biological process • glucose metabolic process • signal transduction • G-protein signaling, coupled to cyclic nucleotide second messenger • G-protein signaling, adenylate cyclase inhibiting pathway • neuropeptide signaling pathway • locomotory behavior • feeding behavior • blood pressure regulation • sensory perception of pain • regulation of body size Sources: Amigo / EGO
RNA expression pattern
250px
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4886	18166
Ensembl	ENSG00000164128	ENSMUSG00000036437
UniProt	P25929	Q3V1K5
RefSeq (mRNA)	NM_000909	NM_010934
RefSeq (protein)	NP_000900	NP_035064
Location (UCSC)	Chr 4: 164.46 - 164.47 Mb	Chr 8: 69.63 - 69.64 Mb
PubMed search	[1]	[2]

Neuropeptide Y receptor type 1 is a protein that in humans is encoded by the NPY1R gene.

Selective Ligands

Agonists

• Neuropeptide Y (endogenous agonist, non subtype selective)
• Peptide YY

Antagonists

Peptide

• BVD-10 (selective NPY₁ antagonist, CAS# 262418-00-8)
• GR-231,118 (mixed NPY₁ antagonist / NPY₄ agonist, CAS# 158859-98-4)

Non-peptide

• BIBO-3304 (CAS# 191868-14-1)
• BIBP-3226 (CAS# 159013-54-4)
• PD-160,170 (CAS# 181468-88-2)

See also

• Neuropeptide Y receptor

External links

• "Neuropeptide Y Receptors: Y₁". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

Further reading

• Wan CP, Lau BH (1997). "Neuropeptide Y receptor subtypes". Life Sci. 56 (13): 1055–64. doi:10.1016/0024-3205(95)00041-4. PMID 9001438. 
• Parker E, Van Heek M, Stamford A (2002). "Neuropeptide Y receptors as targets for anti-obesity drug development: perspective and current status". Eur. J. Pharmacol. 440 (2-3): 173–87. doi:10.1016/S0014-2999(02)01427-9. PMID 12007534. CS1 maint: Multiple names: authors list (link)
• Bettio A, Beck-Sickinger AG (2002). "Biophysical methods to study ligand-receptor interactions of neuropeptide Y". Biopolymers. 60 (6): 420–37. doi:10.1002/1097-0282(2001)60:6<420::AID-BIP10183>3.0.CO;2-W. PMID 12209475. 
• Larhammar D, Blomqvist AG, Yee F; et al. (1992). "Cloning and functional expression of a human neuropeptide Y/peptide YY receptor of the Y1 type". J. Biol. Chem. 267 (16): 10935–8. PMID 1317848. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Herzog H, Hort YJ, Ball HJ; et al. (1992). "Cloned human neuropeptide Y receptor couples to two different second messenger systems". Proc. Natl. Acad. Sci. U.S.A. 89 (13): 5794–8. doi:10.1073/pnas.89.13.5794. PMC 402104 Freely accessible. PMID 1321422. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rose PM, Fernandes P, Lynch JS; et al. (1995). "Cloning and functional expression of a cDNA encoding a human type 2 neuropeptide Y receptor". J. Biol. Chem. 270 (39): 22661–4. doi:10.1074/jbc.270.39.22661. PMID 7559383. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gicquiaux H, Lecat S, Gaire M; et al. (2002). "Rapid internalization and recycling of the human neuropeptide Y Y(1) receptor". J. Biol. Chem. 277 (8): 6645–55. doi:10.1074/jbc.M107224200. PMID 11741903. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sheriff S, F Qureshy A, T Chance W; et al. (2002). "Predominant role by CaM kinase in NPY Y(1) receptor signaling: involvement of CREB [corrected]". Peptides. 23 (1): 87–96. doi:10.1016/S0196-9781(01)00583-6. PMID 11814622. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cox HM, Tough IR (2002). "Neuropeptide Y, Y1, Y2 and Y4 receptors mediate Y agonist responses in isolated human colon mucosa". Br. J. Pharmacol. 135 (6): 1505–12. doi:10.1038/sj.bjp.0704604. PMC 1573267 Freely accessible. PMID 11906964. 
• Uddman R, Möller S, Nilsson T; et al. (2003). "Neuropeptide Y Y1 and neuropeptide Y Y2 receptors in human cardiovascular tissues". Peptides. 23 (5): 927–34. doi:10.1016/S0196-9781(02)00003-7. PMID 12084524. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cantó Soler MV, Gallo JE, Dodds RA; et al. (2002). "Y1 receptor of neuropeptide Y as a glial marker in proliferative vitreoretinopathy and diseased human retina". Glia. 39 (3): 320–4. doi:10.1002/glia.10107. PMID 12203398. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241 Freely accessible. PMID 12477932. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Berglund MM, Schober DA, Statnick MA; et al. (2003). "The use of bioluminescence resonance energy transfer 2 to study neuropeptide Y receptor agonist-induced beta-arrestin 2 interaction". J. Pharmacol. Exp. Ther. 306 (1): 147–56. doi:10.1124/jpet.103.051227. PMID 12665544. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147 Freely accessible. PMID 15231747. 
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 Freely accessible. PMID 15489334. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Körner M, Waser B, Reubi JC (2005). "High expression of neuropeptide y receptors in tumors of the human adrenal gland and extra-adrenal paraganglia". Clin. Cancer Res. 10 (24): 8426–33. doi:10.1158/1078-0432.CCR-04-0821. PMID 15623622. CS1 maint: Multiple names: authors list (link)