Neurotensin receptor 1

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Neurotensin receptor 1 (high affinity)
Identifiers
SymbolsNTSR1; NTR
External IDsOMIM: 162651 MGI: 97386 HomoloGene: 68261 IUPHAR: NTS1 GeneCards: NTSR1 Gene
RNA expression pattern
250px
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez492318216
EnsemblENSG00000101188ENSMUSG00000027568
UniProtP30989Q9QZQ2
RefSeq (mRNA)NM_002531XM_989244
RefSeq (protein)NP_002522XP_994338
Location (UCSC)Chr 20:
60.81 - 60.86 Mb		Chr 2:
180.43 - 180.47 Mb
PubMed search[1][2]

Neurotensin receptor type 1 is a protein that in humans is encoded by the NTSR1 gene.[1][2]

Neurotensin receptor 1 belongs to the large superfamily of G-protein coupled receptors. NTSR1 mediates the multiple functions of neurotensin, such as hypotension, hyperglycemia, hypothermia, antinociception, and regulation of intestinal motility and secretion.[2]

See also

References

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External links

Further reading

  • Vincent JP (1996). "Neurotensin receptors: binding properties, transduction pathways, and structure". Cell. Mol. Neurobiol. 15 (5): 501–12. doi:10.1007/BF02071313. PMID 8719037. 
  • Vincent JP, Mazella J, Kitabgi P (1999). "Neurotensin and neurotensin receptors". Trends Pharmacol. Sci. 20 (7): 302–9. doi:10.1016/S0165-6147(99)01357-7. PMID 10390649. 
  • Vita N, Laurent P, Lefort S; et al. (1993). "Cloning and expression of a complementary DNA encoding a high affinity human neurotensin receptor". FEBS Lett. 317 (1-2): 139–42. doi:10.1016/0014-5793(93)81509-X. PMID 8381365. 
  • Le F, Groshan K, Zeng XP, Richelson E (1997). "Characterization of the genomic structure, promoter region, and a tetranucleotide repeat polymorphism of the human neurotensin receptor gene". J. Biol. Chem. 272 (2): 1315–22. doi:10.1074/jbc.272.2.1315. PMID 8995438. 
  • Boudin H, Pélaprat D, Rostène W; et al. (1998). "Correlative ultrastructural distribution of neurotensin receptor proteins and binding sites in the rat substantia nigra". J. Neurosci. 18 (20): 8473–84. PMID 9763490. 
  • Ye X, Mehlen P, Rabizadeh S; et al. (1999). "TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction". J. Biol. Chem. 274 (42): 30202–8. doi:10.1074/jbc.274.42.30202. PMID 10514511. 
  • Wang L, Friess H, Zhu Z; et al. (2000). "Neurotensin receptor-1 mRNA analysis in normal pancreas and pancreatic disease". Clin. Cancer Res. 6 (2): 566–71. PMID 10690540. 
  • Cusack B, Jansen K, McCormick DJ; et al. (2000). "A single amino acid of the human and rat neurotensin receptors (subtype 1) determining the pharmacological profile of a species-selective neurotensin agonist". Biochem. Pharmacol. 60 (6): 793–801. doi:10.1016/S0006-2952(00)00409-3. PMID 10930533. 
  • Oakley RH, Laporte SA, Holt JA; et al. (2001). "Molecular determinants underlying the formation of stable intracellular G protein-coupled receptor-beta-arrestin complexes after receptor endocytosis*". J. Biol. Chem. 276 (22): 19452–60. doi:10.1074/jbc.M101450200. PMID 11279203. 
  • Leplatois P, Josse A, Guillemot M; et al. (2001). "Neurotensin induces mating in Saccharomyces cerevisiae cells that express human neurotensin receptor type 1 in place of the endogenous pheromone receptor". Eur. J. Biochem. 268 (18): 4860–7. doi:10.1046/j.0014-2956.2001.02407.x. PMID 11559354. 
  • Deloukas P, Matthews LH, Ashurst J; et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052. 
  • Lundquist JT, Büllesbach EE, Golden PL, Dix TA (2002). "Topography of the neurotensin (NT)(8-9) binding site of human NT receptor-1 probed with NT(8-13) analogs". J. Pept. Res. 59 (2): 55–61. PMID 11906607. 
  • Somaï S, Gompel A, Rostène W, Forgez P (2002). "Neurotensin counteracts apoptosis in breast cancer cells". Biochem. Biophys. Res. Commun. 295 (2): 482–8. doi:10.1016/S0006-291X(02)00703-9. PMID 12150975. 
  • Martin S, Navarro V, Vincent JP, Mazella J (2002). "Neurotensin receptor-1 and -3 complex modulates the cellular signaling of neurotensin in the HT29 cell line". Gastroenterology. 123 (4): 1135–43. doi:10.1053/gast.2002.36000. PMID 12360476. 
  • Toy-Miou-Leong M, Cortes CL, Beaudet A; et al. (2004). "Receptor trafficking via the perinuclear recycling compartment accompanied by cell division is necessary for permanent neurotensin cell sensitization and leads to chronic mitogen-activated protein kinase activation". J. Biol. Chem. 279 (13): 12636–46. doi:10.1074/jbc.M303384200. PMID 14699144. 
  • Magazin M, Poszepczynska-Guigné E, Bagot M; et al. (2004). "Sezary syndrome cells unlike normal circulating T lymphocytes fail to migrate following engagement of NT1 receptor". J. Invest. Dermatol. 122 (1): 111–8. doi:10.1046/j.0022-202X.2003.22131.x. PMID 14962098. 
  • Brun P, Mastrotto C, Beggiao E; et al. (2005). "Neuropeptide neurotensin stimulates intestinal wound healing following chronic intestinal inflammation". Am. J. Physiol. Gastrointest. Liver Physiol. 288 (4): G621–9. doi:10.1152/ajpgi.00140.2004. PMID 15764810. 
40x30px This transmembrane receptor-related article is a stub. You can help ssf by expanding it.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Class A: Rhodopsin like
α1 (A, B, D) · α2 (A, B, C) · β1 · β2 · β3
Adenosine (A1, A2A, A2B, A3) · P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
(all but 5-HT3) 5-HT1 (A, B, D, E, F) · 5-HT2 (A, B, C) · 5-HT (4, 5A, 6, 7)
Other
Acetylcholine (M1, M2, M3, M4, M5) · Dopamine (D1, D2, D3, D4, D5) · Histamine (H1, H2, H3, H4) · Melatonin (1A, 1B, 1C) · TAAR (1, 2, 3, 5, 6, 8, 9)
Metabolites and
signaling molecules
CysLT (1, 2) · LTB4 (1, 2) · FPRL1 · OXE · Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) · Prostacyclin · Thromboxane
Other
Bile acid · Cannabinoid (CB1, CB2, GPR (18, 55, 119)) · EBI2 · Estrogen · Free fatty acid (1, 2, 3, 4) · Lactate  · Lysophosphatidic acid (1, 2, 3, 4, 5, 6)  · Lysophospholipid (1, 2, 3, 4, 5, 6, 7, 8) · Niacin (1, 2) · Oxoglutarate · PAF · Sphingosine-1-phosphate (1, 2, 3, 4, 5) · Succinate
Peptide
B/W (1, 2) · FF (1, 2) · S · Y (1, 2, 4, 5) · Neuromedin (B, U (1, 2)) · Neurotensin (1, 2)
Other
Miscellaneous
GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Other
Class B: Secretin like
GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Other
Class C: Metabotropic
glutamate / pheromone
TAS1R (1, 2, 3) · TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Other
Class F:
Frizzled / Smoothened
Frizzled
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Smoothened
  1. ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
  2. ↑ 2.0 2.1 "Entrez Gene: NTSR1 neurotensin receptor 1 (high affinity)". 
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