Prokineticin receptor 2

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Prokineticin receptor 2
Identifiers
Symbols	PROKR2; KAL3; PKR2; GPR73L1; GPR73b; GPRg2; dJ680N4.3
External IDs	OMIM: 607123 MGI: 2181363 HomoloGene: 16368 IUPHAR: PKR2 GeneCards: PROKR2 Gene
Gene Ontology Molecular function • rhodopsin-like receptor activity • receptor activity • neuropeptide Y receptor activity Cellular component • membrane • integral to membrane Biological process • signal transduction • G-protein coupled receptor protein signaling pathway • circadian rhythm Sources: Amigo / EGO
RNA expression pattern
250px
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	128674	246313
Ensembl	ENSG00000101292	ENSMUSG00000050558
UniProt	Q8NFJ6	Q6GTF8
RefSeq (mRNA)	NM_144773	NM_144944
RefSeq (protein)	NP_658986	NP_659193
Location (UCSC)	Chr 20: 5.23 - 5.24 Mb	Chr 2: 132.06 - 132.08 Mb
PubMed search	[1]	[2]

Prokineticin receptor 2 (PKR₂), in a G-protein coupled receptor encoded by the PROKR2 gene in humans.

Prokineticins are secreted proteins that can promote angiogenesis and induce strong gastrointestinal smooth muscle contraction. The protein encoded by this gene is an integral membrane protein and G protein-coupled receptor for prokineticins. The encoded protein is similar in sequence to GPR73, another G protein-coupled receptor for prokineticins.

See also

• Prokineticin receptor
• Kallmann syndrome

External links

• "Prokineticin Receptors: PKR₂". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

Further reading

• Deloukas P, Matthews LH, Ashurst J; et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lin DC, Bullock CM, Ehlert FJ; et al. (2002). "Identification and molecular characterization of two closely related G protein-coupled receptors activated by prokineticins/endocrine gland vascular endothelial growth factor". J. Biol. Chem. 277 (22): 19276–80. doi:10.1074/jbc.M202139200. PMID 11886876. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Soga T, Matsumoto S, Oda T; et al. (2003). "Molecular cloning and characterization of prokineticin receptors". Biochim. Biophys. Acta. 1579 (2-3): 173–9. PMID 12427552. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241 Freely accessible. PMID 12477932. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Battersby S, Critchley HO, Morgan K; et al. (2004). "Expression and regulation of the prokineticins (endocrine gland-derived vascular endothelial growth factor and Bv8) and their receptors in the human endometrium across the menstrual cycle". J. Clin. Endocrinol. Metab. 89 (5): 2463–9. doi:10.1210/jc.2003-032012. PMID 15126578. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 Freely accessible. PMID 15489334. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pasquali D, Rossi V, Staibano S; et al. (2006). "The endocrine-gland-derived vascular endothelial growth factor (EG-VEGF)/prokineticin 1 and 2 and receptor expression in human prostate: Up-regulation of EG-VEGF/prokineticin 1 with malignancy". Endocrinology. 147 (9): 4245–51. doi:10.1210/en.2006-0614. PMID 16763065. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dodé C, Teixeira L, Levilliers J; et al. (2006). "Kallmann syndrome: mutations in the genes encoding prokineticin-2 and prokineticin receptor-2". PLoS Genet. 2 (10): e175. doi:10.1371/journal.pgen.0020175. PMC 1617130 Freely accessible. PMID 17054399. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.