P2RY1

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Purinergic receptor P2Y, G-protein coupled, 1
Identifiers
Symbols	P2RY1; P2Y1
External IDs	OMIM: 601167 MGI: 105049 HomoloGene: 1926 IUPHAR: P2Y1 GeneCards: P2RY1 Gene
Gene Ontology Molecular function • rhodopsin-like receptor activity • receptor activity • purinergic nucleotide receptor activity, G-protein coupled Cellular component • integral to plasma membrane • membrane Biological process • G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) • blood coagulation Sources: Amigo / EGO
RNA expression pattern
250px
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5028	18441
Ensembl	ENSG00000169860	ENSMUSG00000027765
UniProt	P47900	Q544J5
RefSeq (mRNA)	NM_002563	NM_008772
RefSeq (protein)	NP_002554	NP_032798
Location (UCSC)	Chr 3: 154.04 - 154.04 Mb	Chr 3: 61.09 - 61.1 Mb
PubMed search	[1]	[2]

P2Y purinoceptor 1 is a protein that in humans is encoded by the P2RY1 gene.

The product of this gene, P2Y₁ belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor functions as a receptor for extracellular ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation.

See also

• P2Y receptor

External links

• "P2Y Receptors: P2Y₁". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

Further reading

• Janssens R, Communi D, Pirotton S; et al. (1996). "Cloning and tissue distribution of the human P2Y1 receptor". Biochem. Biophys. Res. Commun. 221 (3): 588–93. doi:10.1006/bbrc.1996.0640. PMID 8630005. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Léon C, Vial C, Cazenave JP, Gachet C (1996). "Cloning and sequencing of a human cDNA encoding endothelial P2Y1 purinoceptor". Gene. 171 (2): 295–7. doi:10.1016/0378-1119(96)00027-3. PMID 8666290. CS1 maint: Multiple names: authors list (link)
• Léon C, Hechler B, Vial C; et al. (1997). "The P2Y1 receptor is an ADP receptor antagonized by ATP and expressed in platelets and megakaryoblastic cells". FEBS Lett. 403 (1): 26–30. doi:10.1016/S0014-5793(97)00022-7. PMID 9038354. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ayyanathan K, Naylor SL, Kunapuli SP (1997). "Structural characterization and fine chromosomal mapping of the human P2Y1 purinergic receptor gene (P2RY1)". Somat. Cell Mol. Genet. 22 (5): 419–24. doi:10.1007/BF02369897. PMID 9039850. CS1 maint: Multiple names: authors list (link)
• Maier R, Glatz A, Mosbacher J, Bilbe G (1997). "Cloning of P2Y6 cDNAs and identification of a pseudogene: comparison of P2Y receptor subtype expression in bone and brain tissues". Biochem. Biophys. Res. Commun. 237 (2): 297–302. doi:10.1006/bbrc.1997.7135. PMID 9268704. CS1 maint: Multiple names: authors list (link)
• Jin J, Daniel JL, Kunapuli SP (1998). "Molecular basis for ADP-induced platelet activation. II. The P2Y1 receptor mediates ADP-induced intracellular calcium mobilization and shape change in platelets". J. Biol. Chem. 273 (4): 2030–4. doi:10.1074/jbc.273.4.2030. PMID 9442040. CS1 maint: Multiple names: authors list (link)
• Hall RA, Ostedgaard LS, Premont RT; et al. (1998). "A C-terminal motif found in the beta2-adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na+/H+ exchanger regulatory factor family of PDZ proteins". Proc. Natl. Acad. Sci. U.S.A. 95 (15): 8496–501. doi:10.1073/pnas.95.15.8496. PMC 21104 Freely accessible. PMID 9671706. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sabala P, Czajkowski R, Przybyłek K; et al. (2001). "Two subtypes of G protein-coupled nucleotide receptors, P2Y(1) and P2Y(2) are involved in calcium signalling in glioma C6 cells". Br. J. Pharmacol. 132 (2): 393–402. doi:10.1038/sj.bjp.0703843. PMC 1572584 Freely accessible. PMID 11159687. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yoshioka K, Saitoh O, Nakata H (2001). "Heteromeric association creates a P2Y-like adenosine receptor". Proc. Natl. Acad. Sci. U.S.A. 98 (13): 7617–22. doi:10.1073/pnas.121587098. PMC 34717 Freely accessible. PMID 11390975. CS1 maint: Multiple names: authors list (link)
• James G, Butt AM (2001). "Changes in P2Y and P2X purinoceptors in reactive glia following axonal degeneration in the rat optic nerve". Neurosci. Lett. 312 (1): 33–6. doi:10.1016/S0304-3940(01)02189-9. PMID 11578839. 
• Moore DJ, Chambers JK, Wahlin JP; et al. (2001). "Expression pattern of human P2Y receptor subtypes: a quantitative reverse transcription-polymerase chain reaction study". Biochim. Biophys. Acta. 1521 (1-3): 107–19. PMID 11690642. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Czajkowski R, Lei L, Sabała P, Barańska J (2002). "ADP-evoked phospholipase C stimulation and adenylyl cyclase inhibition in glioma C6 cells occur through two distinct nucleotide receptors, P2Y(1) and P2Y(12)". FEBS Lett. 513 (2-3): 179–83. doi:10.1016/S0014-5793(02)02255-X. PMID 11904146. CS1 maint: Multiple names: authors list (link)
• Aktas B, Hönig-Liedl P, Walter U, Geiger J (2002). "Inhibition of platelet P2Y12 and alpha2A receptor signaling by cGMP-dependent protein kinase". Biochem. Pharmacol. 64 (3): 433–9. doi:10.1016/S0006-2952(02)01113-9. PMID 12147294. CS1 maint: Multiple names: authors list (link)
• Nurden P, Poujol C, Winckler J; et al. (2003). "Immunolocalization of P2Y1 and TPalpha receptors in platelets showed a major pool associated with the membranes of alpha -granules and the open canalicular system". Blood. 101 (4): 1400–8. doi:10.1182/blood-2002-02-0642. PMID 12393588. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241 Freely accessible. PMID 12477932. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Burrell HE, Bowler WB, Gallagher JA, Sharpe GR (2003). "Human keratinocytes express multiple P2Y-receptors: evidence for functional P2Y1, P2Y2, and P2Y4 receptors". J. Invest. Dermatol. 120 (3): 440–7. doi:10.1046/j.1523-1747.2003.12050.x. PMID 12603858. CS1 maint: Multiple names: authors list (link)
• Jagroop IA, Burnstock G, Mikhailidis DP (2003). "Both the ADP receptors P2Y1 and P2Y12, play a role in controlling shape change in human platelets". Platelets. 14 (1): 15–20. doi:10.1080/0953710021000062914. PMID 12623443. CS1 maint: Multiple names: authors list (link)
• Greig AV, Linge C, Terenghi G; et al. (2003). "Purinergic receptors are part of a functional signaling system for proliferation and differentiation of human epidermal keratinocytes". J. Invest. Dermatol. 120 (6): 1007–15. doi:10.1046/j.1523-1747.2003.12261.x. PMID 12787128. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wang L, Ostberg O, Wihlborg AK; et al. (2003). "Quantification of ADP and ATP receptor expression in human platelets". J. Thromb. Haemost. 1 (2): 330–6. doi:10.1046/j.1538-7836.2003.00070.x. PMID 12871508. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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