EMR1

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Egf-like module containing, mucin-like, hormone receptor-like 1
Identifiers
Symbols	EMR1; TM7LN3
External IDs	OMIM: 600493 MGI: 106912 HomoloGene: 1493 IUPHAR: EMR1 GeneCards: EMR1 Gene
Gene Ontology Molecular function • receptor activity • G-protein coupled receptor activity • calcium ion binding Cellular component • integral to plasma membrane • membrane • integral to membrane Biological process • cell adhesion • signal transduction • neuropeptide signaling pathway Sources: Amigo / EGO
RNA expression pattern
250px
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2015	13733
Ensembl	ENSG00000174837	ENSMUSG00000004730
UniProt	Q14246	Q3S4B0
RefSeq (mRNA)	NM_001974	NM_010130
RefSeq (protein)	NP_001965	NP_034260
Location (UCSC)	Chr 19: 6.84 - 6.89 Mb	Chr 17: 57.04 - 57.17 Mb
PubMed search	[1]	[2]

EGF-like module-containing mucin-like hormone receptor-like 1 is a protein that in humans is encoded by the EMR1 gene.

This gene encodes a protein that has a domain resembling seven transmembrane G protein-coupled hormone receptors (7TM receptors) at its C-terminus. The N-terminus of the encoded protein has six EGF-like modules, separated from the transmembrane segments by a serine/threonine-rich domain, a feature reminiscent of mucin-like, single-span, integral membrane glycoproteins with adhesive properties.

See also

• EGF module-containing mucin-like hormone receptor

Further reading

• McKnight AJ, Macfarlane AJ, Seldin MF, Gordon S (1998). "Chromosome mapping of the Emr1 gene". Mamm. Genome. 8 (12): 946. doi:10.1007/s003359900633. PMID 9383301. CS1 maint: Multiple names: authors list (link)
• Carver EA, Hamann J, Olsen AS, Stubbs L (2000). "Physical mapping of EMR1 and CD97 in human Chromosome 19 and assignment of Cd97 to mouse Chromosome 8 suggest an ancient genomic duplication". Mamm. Genome. 10 (10): 1039–40. doi:10.1007/s003359901157. PMID 10501980. CS1 maint: Multiple names: authors list (link)
• Lin HH, Stacey M, Hamann J; et al. (2000). "Human EMR2, a novel EGF-TM7 molecule on chromosome 19p13.1, is closely related to CD97". Genomics. 67 (2): 188–200. doi:10.1006/geno.2000.6238. PMID 10903844. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241 Freely accessible. PMID 12477932. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 Freely accessible. PMID 15489334. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.