Secretin receptor

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Secretin receptor
Identifiers
SymbolsSCTR; SR
External IDsOMIM: 182098 HomoloGene: 68290 IUPHAR: secretin GeneCards: SCTR Gene
RNA expression pattern
250px
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez6344n/a
EnsemblENSG00000080293n/a
UniProtP47872n/a
RefSeq (mRNA)NM_002980n/a
RefSeq (protein)NP_002971n/a
Location (UCSC)Chr 2:
119.91 - 120 Mb		n/a
PubMed search[1]n/a

Human secretin receptor (gene name SCTR) is a G protein-coupled receptor which binds secretin and is the leading member (i.e., first cloned) of the class B GPCR subfamily.[1]

Interactions

Secretin receptor has been shown to interact with Pituitary adenylate cyclase activating peptide.[2]

References

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Further reading

  • Ulrich CD, Holtmann M, Miller LJ (1998). "Secretin and vasoactive intestinal peptide receptors: members of a unique family of G protein-coupled receptors". Gastroenterology. 114 (2): 382–97. doi:10.1016/S0016-5085(98)70491-3. PMID 9453500. 
  • Felley CP, Qian JM, Mantey S; et al. (1993). "Chief cells possess a receptor with high affinity for PACAP and VIP that stimulates pepsinogen release". Am. J. Physiol. 263 (6 Pt 1): G901–7. PMID 1335692. 
  • Ishihara T, Nakamura S, Kaziro Y; et al. (1991). "Molecular cloning and expression of a cDNA encoding the secretin receptor". EMBO J. 10 (7): 1635–41. PMC 452832 Freely accessible. PMID 1646711. 
  • Robberecht P, De Neef P, Waelbroeck M; et al. (1988). "Secretin receptors in human pancreatic membranes". Pancreas. 3 (5): 529–35. doi:10.1097/00006676-198810000-00004. PMID 3186683. 
  • Chow BK (1995). "Molecular cloning and functional characterization of a human secretin receptor". Biochem. Biophys. Res. Commun. 212 (1): 204–11. doi:10.1006/bbrc.1995.1957. PMID 7612008. 
  • Patel DR, Kong Y, Sreedharan SP (1995). "Molecular cloning and expression of a human secretin receptor". Mol. Pharmacol. 47 (3): 467–73. PMID 7700244. 
  • Holtmann MH, Hadac EM, Miller LJ (1995). "Critical contributions of amino-terminal extracellular domains in agonist binding and activation of secretin and vasoactive intestinal polypeptide receptors. Studies of chimeric receptors". J. Biol. Chem. 270 (24): 14394–8. doi:10.1074/jbc.270.24.14394. PMID 7782300. 
  • Jiang S, Ulrich C (1995). "Molecular cloning and functional expression of a human pancreatic secretin receptor". Biochem. Biophys. Res. Commun. 207 (3): 883–90. doi:10.1006/bbrc.1995.1268. PMID 7864894. 
  • Sreedharan SP, Patel DR, Huang JX, Goetzl EJ (1993). "Cloning and functional expression of a human neuroendocrine vasoactive intestinal peptide receptor". Biochem. Biophys. Res. Commun. 193 (2): 546–53. doi:10.1006/bbrc.1993.1658. PMID 8390245. 
  • Mark HF, Chow BK (1996). "Localization of the gene encoding the secretin receptor, SCTR, on human chromosome 2q14.1 by fluorescence in situ hybridization and chromosome morphometry". Genomics. 29 (3): 817–8. doi:10.1006/geno.1995.9922. PMID 8575789. 
  • Vilardaga JP, di Paolo E, de Neef P; et al. (1996). "Lysine 173 residue within the first exoloop of rat secretin receptor is involved in carboxylate moiety recognition of Asp 3 in secretin". Biochem. Biophys. Res. Commun. 218 (3): 842–6. doi:10.1006/bbrc.1996.0150. PMID 8579602. 
  • Chow BK (1998). "Functional antagonism of the human secretin receptor by a recombinant protein encoding the N-terminal ectodomain of the receptor". Receptors & signal transduction. 7 (3): 143–50. PMID 9440501. 
  • Shetzline MA, Premont RT, Walker JK; et al. (1998). "A role for receptor kinases in the regulation of class II G protein-coupled receptors. Phosphorylation and desensitization of the secretin receptor". J. Biol. Chem. 273 (12): 6756–62. doi:10.1074/jbc.273.12.6756. PMID 9506976. 
  • Ho PK, Fong RS, Kai HS; et al. (1999). "The human secretin receptor gene: genomic organization and promoter characterization". FEBS Lett. 455 (3): 209–14. doi:10.1016/S0014-5793(99)00864-9. PMID 10437774. 
  • Pang RT, Ng SS, Cheng CH; et al. (1999). "Role of N-linked glycosylation on the function and expression of the human secretin receptor". Endocrinology. 140 (11): 5102–11. doi:10.1210/en.140.11.5102. PMID 10537138. 
  • Chan KY, Pang RT, Chow BK (2001). "Functional segregation of the highly conserved basic motifs within the third endoloop of the human secretin receptor". Endocrinology. 142 (9): 3926–34. doi:10.1210/en.142.9.3926. PMID 11517171. 
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241 Freely accessible. PMID 12477932. 
  • Pang RT, Lee LT, Ng SS; et al. (2004). "CpG methylation and transcription factors Sp1 and Sp3 regulate the expression of the human secretin receptor gene". Mol. Endocrinol. 18 (2): 471–83. doi:10.1210/me.2003-0245. PMID 14645499. 
  • Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 

External links

40x30px This transmembrane receptor-related article is a stub. You can help ssf by expanding it.
Class A: Rhodopsin like
α1 (A, B, D) · α2 (A, B, C) · β1 · β2 · β3
Adenosine (A1, A2A, A2B, A3) · P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
(all but 5-HT3) 5-HT1 (A, B, D, E, F) · 5-HT2 (A, B, C) · 5-HT (4, 5A, 6, 7)
Other
Acetylcholine (M1, M2, M3, M4, M5) · Dopamine (D1, D2, D3, D4, D5) · Histamine (H1, H2, H3, H4) · Melatonin (1A, 1B, 1C) · TAAR (1, 2, 3, 5, 6, 8, 9)
Metabolites and
signaling molecules
CysLT (1, 2) · LTB4 (1, 2) · FPRL1 · OXE · Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) · Prostacyclin · Thromboxane
Other
Bile acid · Cannabinoid (CB1, CB2, GPR (18, 55, 119)) · EBI2 · Estrogen · Free fatty acid (1, 2, 3, 4) · Lactate  · Lysophosphatidic acid (1, 2, 3, 4, 5, 6)  · Lysophospholipid (1, 2, 3, 4, 5, 6, 7, 8) · Niacin (1, 2) · Oxoglutarate · PAF · Sphingosine-1-phosphate (1, 2, 3, 4, 5) · Succinate
Peptide
B/W (1, 2) · FF (1, 2) · S · Y (1, 2, 4, 5) · Neuromedin (B, U (1, 2)) · Neurotensin (1, 2)
Other
Miscellaneous
GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Other
Class B: Secretin like
GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Other
Class C: Metabotropic
glutamate / pheromone
TAS1R (1, 2, 3) · TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Other
Class F:
Frizzled / Smoothened
Frizzled
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Smoothened
  1. ↑ Dong M, Miller LJ (2002). "Molecular pharmacology of the secretin receptor". Recept. Channels. 8 (3-4): 189–200. doi:10.1080/10606820213686. PMID 12529936. 
  2. ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
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