LPAR3

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Lysophosphatidic acid receptor 3
Identifiers
Symbols	LPAR3; GPCR; EDG7; HOFNH30; LP-A3; LPA3; LPAR3; RP4-678I3
External IDs	OMIM: 605106 MGI: 1929469 HomoloGene: 8123 IUPHAR: LPA3 GeneCards: LPAR3 Gene
Gene Ontology Molecular function • lysosphingolipid and lysophosphatidic acid receptor activity • receptor activity • lipid binding Cellular component • plasma membrane • integral to plasma membrane Biological process • signal transduction • G-protein signaling, coupled to cyclic nucleotide second messenger • elevation of cytosolic calcium ion concentration • synaptic transmission Sources: Amigo / EGO
RNA expression pattern
250px
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	23566	65086
Ensembl	ENSG00000171517	ENSMUSG00000036832
UniProt	Q9UBY5	Q544B4
RefSeq (mRNA)	NM_012152	NM_022983
RefSeq (protein)	NP_036284	NP_075359
Location (UCSC)	Chr 1: 85.05 - 85.1 Mb	Chr 3: 146.16 - 146.22 Mb
PubMed search	[1]	[2]

Lysophosphatidic acid receptor 3 also known as LPA₃ is a protein that in humans is encoded by the LPAR3 gene. LPA₃ is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).

Function

This gene encodes a member of the G protein-coupled receptor family, as well as the EDG family of proteins. This protein functions as a cellular receptor for lysophosphatidic acid and mediates lysophosphatidic acid-evoked calcium mobilization. This receptor couples predominantly to G(q/11) alpha proteins.

See also

• Lysophospholipid receptor

External links

• "Lysophospholipid Receptors: LPA₃". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

Further reading

• Contos JJ, Ishii I, Chun J (2001). "Lysophosphatidic acid receptors". Mol. Pharmacol. 58 (6): 1188–96. PMID 11093753. CS1 maint: Multiple names: authors list (link)
• Im DS, Heise CE, Harding MA; et al. (2000). "Molecular cloning and characterization of a lysophosphatidic acid receptor, Edg-7, expressed in prostate". Mol. Pharmacol. 57 (4): 753–9. PMID 10727522. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fitzgerald LR, Dytko GM, Sarau HM; et al. (2000). "Identification of an EDG7 variant, HOFNH30, a G-protein-coupled receptor for lysophosphatidic acid". Biochem. Biophys. Res. Commun. 273 (3): 805–10. doi:10.1006/bbrc.2000.2943. PMID 10891327. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tokumura A, Sinomiya J, Kishimoto S; et al. (2002). "Human platelets respond differentially to lysophosphatidic acids having a highly unsaturated fatty acyl group and alkyl ether-linked lysophosphatidic acids". Biochem. J. 365 (Pt 3): 617–28. doi:10.1042/BJ20020348. PMID 11982483. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hama K, Bandoh K, Kakehi Y; et al. (2002). "Lysophosphatidic acid (LPA) receptors are activated differentially by biological fluids: possible role of LPA-binding proteins in activation of LPA receptors". FEBS Lett. 523 (1-3): 187–92. doi:10.1016/S0014-5793(02)02976-9. PMID 12123830. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cremers B, Flesch M, Kostenis E; et al. (2003). "Modulation of myocardial contractility by lysophosphatidic acid (LPA)". J. Mol. Cell. Cardiol. 35 (1): 71–80. doi:10.1016/S0022-2828(02)00279-1. PMID 12623301. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fujita T, Miyamoto S, Onoyama I; et al. (2003). "Expression of lysophosphatidic acid receptors and vascular endothelial growth factor mediating lysophosphatidic acid in the development of human ovarian cancer". Cancer Lett. 192 (2): 161–9. doi:10.1016/S0304-3835(02)00713-9. PMID 12668280. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jin Y, Knudsen E, Wang L, Maghazachi AA (2003). "Lysophosphatidic acid induces human natural killer cell chemotaxis and intracellular calcium mobilization". Eur. J. Immunol. 33 (8): 2083–9. doi:10.1002/eji.200323711. PMID 12884281. CS1 maint: Multiple names: authors list (link)
• Xing Y, Ganji SH, Noh JW, Kamanna VS (2005). "Cell density-dependent expression of EDG family receptors and mesangial cell proliferation: role in lysophosphatidic acid-mediated cell growth". Am. J. Physiol. Renal Physiol. 287 (6): F1250–7. doi:10.1152/ajprenal.00342.2003. PMID 15292052. CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.