TAS2R13
| edit |
| Taste receptor, type 2, member 13 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | TAS2R13; T2R13; TRB3 | ||||||||||||
| External IDs | OMIM: 604792 MGI: 2681259 HomoloGene: 41542 GeneCards: TAS2R13 Gene | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 50838 | 387349 | |||||||||||
| Ensembl | ENSG00000212128 | ENSMUSG00000071150 | |||||||||||
| UniProt | Q9NYV9 | Q7M720 | |||||||||||
| RefSeq (mRNA) | NM_023920 | NM_207024 | |||||||||||
| RefSeq (protein) | NP_076409 | NP_996907 | |||||||||||
| Location (UCSC) | Chr 12: 11.06 - 11.06 Mb | Chr 6: 132.67 - 132.67 Mb | |||||||||||
| PubMed search | [1] | [2] | |||||||||||
Taste receptor type 2 member 13 is a protein that in humans is encoded by the TAS2R13 gene.[1][2][3]
This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13.[3]
See also
References
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- Kinnamon SC (2000). "A plethora of taste receptors". Neuron. 25 (3): 507–10. doi:10.1016/S0896-6273(00)81054-5. PMID 10774719.
- Margolskee RF (2002). "Molecular mechanisms of bitter and sweet taste transduction". J. Biol. Chem. 277 (1): 1–4. doi:10.1074/jbc.R100054200. PMID 11696554.
- Montmayeur JP, Matsunami H (2002). "Receptors for bitter and sweet taste". Curr. Opin. Neurobiol. 12 (4): 366–71. doi:10.1016/S0959-4388(02)00345-8. PMID 12139982.
- Chandrashekar J, Mueller KL, Hoon MA; et al. (2000). "T2Rs function as bitter taste receptors". Cell. 100 (6): 703–11. doi:10.1016/S0092-8674(00)80706-0. PMID 10761935.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241 Freely accessible. PMID 12477932.
- Zhang Y, Hoon MA, Chandrashekar J; et al. (2003). "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways". Cell. 112 (3): 293–301. doi:10.1016/S0092-8674(03)00071-0. PMID 12581520.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 Freely accessible. PMID 15489334.
- Fischer A, Gilad Y, Man O, Pääbo S (2005). "Evolution of bitter taste receptors in humans and apes". Mol. Biol. Evol. 22 (3): 432–6. doi:10.1093/molbev/msi027. PMID 15496549.
- Go Y, Satta Y, Takenaka O, Takahata N (2006). "Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates". Genetics. 170 (1): 313–26. doi:10.1534/genetics.104.037523. PMC 1449719 Freely accessible. PMID 15744053.
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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- ↑ 3.0 3.1 "Entrez Gene: TAS2R13 taste receptor, type 2, member 13".
