TAS1R3

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Taste receptor, type 1, member 3
Identifiers
SymbolsTAS1R3; T1R3
External IDsOMIM: 605865 MGI: 1933547 HomoloGene: 12890 GeneCards: TAS1R3 Gene
Orthologs
SpeciesHumanMouse
Entrez8375683771
EnsemblENSG00000169962ENSMUSG00000029072
UniProtQ7RTX0Q925D8
RefSeq (mRNA)NM_152228NM_031872
RefSeq (protein)NP_689414NP_114078
Location (UCSC)Chr 1:
1.26 - 1.26 Mb		Chr 4:
154.7 - 154.71 Mb
PubMed search[1][2]

Taste receptor type 1 member 3 is a protein that in humans is encoded by the TAS1R3 gene.[1][2]

The TAS1R3 gene encodes the human homolog of mouse Sac, a major determinant of differences between sweet-sensitive and -insensitive mouse strains in their responsiveness to sucrose, saccharin, and other sweeteners.[supplied by OMIM][2]

See also

References

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Further reading

  • Chandrashekar J, Hoon MA, Ryba NJ, Zuker CS (2007). "The receptors and cells for mammalian taste". Nature. 444 (7117): 288–94. doi:10.1038/nature05401. PMID 17108952. 
  • Max M, Shanker YG, Huang L; et al. (2001). "Tas1r3, encoding a new candidate taste receptor, is allelic to the sweet responsiveness locus Sac". Nat. Genet. 28 (1): 58–63. doi:10.1038/88270. PMID 11326277. 
  • Nelson G, Chandrashekar J, Hoon MA; et al. (2002). "An amino-acid taste receptor". Nature. 416 (6877): 199–202. doi:10.1038/nature726. PMID 11894099. 
  • Li X, Staszewski L, Xu H; et al. (2002). "Human receptors for sweet and umami taste". Proc. Natl. Acad. Sci. U.S.A. 99 (7): 4692–6. doi:10.1073/pnas.072090199. PMC 123709 Freely accessible. PMID 11917125. 
  • Spadaccini R, Trabucco F, Saviano G; et al. (2003). "The mechanism of interaction of sweet proteins with the T1R2-T1R3 receptor: evidence from the solution structure of G16A-MNEI". J. Mol. Biol. 328 (3): 683–92. doi:10.1016/S0022-2836(03)00346-2. PMID 12706725. 
  • Ariyasu T, Matsumoto S, Kyono F; et al. (2004). "Taste receptor T1R3 is an essential molecule for the cellular recognition of the disaccharide trehalose". In Vitro Cell. Dev. Biol. Anim. 39 (1-2): 80–8. doi:10.1290/1543-706X(2003)039<0080:TRTIAE>2.0.CO;2. PMID 12892531. 
  • Jiang P, Ji Q, Liu Z; et al. (2004). "The cysteine-rich region of T1R3 determines responses to intensely sweet proteins". J. Biol. Chem. 279 (43): 45068–75. doi:10.1074/jbc.M406779200. PMID 15299024. 
  • Xu H, Staszewski L, Tang H; et al. (2005). "Different functional roles of T1R subunits in the heteromeric taste receptors". Proc. Natl. Acad. Sci. U.S.A. 101 (39): 14258–63. doi:10.1073/pnas.0404384101. PMC 521102 Freely accessible. PMID 15353592. 
  • Taniguchi K (2005). "Expression of the sweet receptor protein, T1R3, in the human liver and pancreas". J. Vet. Med. Sci. 66 (11): 1311–4. doi:10.1292/jvms.66.1311. PMID 15585941. 
  • Jiang P, Cui M, Zhao B; et al. (2005). "Lactisole interacts with the transmembrane domains of human T1R3 to inhibit sweet taste". J. Biol. Chem. 280 (15): 15238–46. doi:10.1074/jbc.M414287200. PMID 15668251. 
  • Galindo-Cuspinera V, Winnig M, Bufe B; et al. (2006). "A TAS1R receptor-based explanation of sweet 'water-taste'". Nature. 441 (7091): 354–7. doi:10.1038/nature04765. PMID 16633339. 
  • Gregory SG, Barlow KF, McLay KE; et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414. 
  • Behrens M, Bartelt J, Reichling C; et al. (2006). "Members of RTP and REEP gene families influence functional bitter taste receptor expression". J. Biol. Chem. 281 (29): 20650–9. doi:10.1074/jbc.M513637200. PMID 16720576. 
  • Koizumi A, Nakajima K, Asakura T; et al. (2007). "Taste-modifying sweet protein, neoculin, is received at human T1R3 amino terminal domain". Biochem. Biophys. Res. Commun. 358 (2): 585–9. doi:10.1016/j.bbrc.2007.04.171. PMID 17499612. 
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Class A: Rhodopsin like
α1 (A, B, D) · α2 (A, B, C) · β1 · β2 · β3
Adenosine (A1, A2A, A2B, A3) · P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
(all but 5-HT3) 5-HT1 (A, B, D, E, F) · 5-HT2 (A, B, C) · 5-HT (4, 5A, 6, 7)
Other
Acetylcholine (M1, M2, M3, M4, M5) · Dopamine (D1, D2, D3, D4, D5) · Histamine (H1, H2, H3, H4) · Melatonin (1A, 1B, 1C) · TAAR (1, 2, 3, 5, 6, 8, 9)
Metabolites and
signaling molecules
CysLT (1, 2) · LTB4 (1, 2) · FPRL1 · OXE · Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) · Prostacyclin · Thromboxane
Other
Bile acid · Cannabinoid (CB1, CB2, GPR (18, 55, 119)) · EBI2 · Estrogen · Free fatty acid (1, 2, 3, 4) · Lactate  · Lysophosphatidic acid (1, 2, 3, 4, 5, 6)  · Lysophospholipid (1, 2, 3, 4, 5, 6, 7, 8) · Niacin (1, 2) · Oxoglutarate · PAF · Sphingosine-1-phosphate (1, 2, 3, 4, 5) · Succinate
Peptide
B/W (1, 2) · FF (1, 2) · S · Y (1, 2, 4, 5) · Neuromedin (B, U (1, 2)) · Neurotensin (1, 2)
Other
Miscellaneous
GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Other
Class B: Secretin like
GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Other
Class C: Metabotropic
glutamate / pheromone
TAS1R (1, 2, 3) · TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Other
Class F:
Frizzled / Smoothened
Frizzled
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Smoothened
  1. ↑ Lua error in package.lua at line 80: module 'Module:Citation/CS1/Suggestions' not found.
  2. ↑ 2.0 2.1 "Entrez Gene: TAS1R3 taste receptor, type 1, member 3". 
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