FZD5

edit

Frizzled homolog 5 (Drosophila)
Identifiers
Symbols	FZD5; C2orf31; DKFZP434E2135; HFZ5; MGC129692
External IDs	OMIM: 601723 MGI: 108571 HomoloGene: 2590 IUPHAR: FZD5 GeneCards: FZD5 Gene
Gene Ontology Molecular function • receptor activity • non-G-protein coupled 7TM receptor activity • G-protein coupled receptor activity • protein binding Cellular component • integral to plasma membrane • membrane Biological process • establishment of tissue polarity • G-protein coupled receptor protein signaling pathway • multicellular organismal development • Wnt receptor signaling pathway • cell maturation Sources: Amigo / EGO
RNA expression pattern
250px
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7855	14367
Ensembl	ENSG00000163251	ENSMUSG00000045005
UniProt	Q13467	Q149L3
RefSeq (mRNA)	NM_003468	NM_001033193
RefSeq (protein)	NP_003459	NP_001028365
Location (UCSC)	Chr 2: 208.34 - 208.34 Mb	Chr 1: 64.67 - 64.67 Mb
PubMed search	[1]	[2]

Frizzled-5 is a protein that in humans is encoded by the FZD5 gene.

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD5 protein is believed to be the receptor for the Wnt5A ligand.

See also

• Frizzled

External links

• "Frizzled Receptors: FZD₅". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

Further reading

• He X, Saint-Jeannet JP, Wang Y; et al. (1997). "A member of the Frizzled protein family mediating axis induction by Wnt-5A". Science. 275 (5306): 1652–4. doi:10.1126/science.275.5306.1652. PMID 9054360. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Finch PW, He X, Kelley MJ; et al. (1997). "Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action". Proc. Natl. Acad. Sci. U.S.A. 94 (13): 6770–5. doi:10.1073/pnas.94.13.6770. PMC 21233 Freely accessible. PMID 9192640. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tanaka S, Akiyoshi T, Mori M; et al. (1998). "A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals". Proc. Natl. Acad. Sci. U.S.A. 95 (17): 10164–9. doi:10.1073/pnas.95.17.10164. PMC 21479 Freely accessible. PMID 9707618. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tamai K, Semenov M, Kato Y; et al. (2000). "LDL-receptor-related proteins in Wnt signal transduction". Nature. 407 (6803): 530–5. doi:10.1038/35035117. PMID 11029007. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wiemann S, Weil B, Wellenreuther R; et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMC 311072 Freely accessible. PMID 11230166. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yao R, Maeda T, Takada S, Noda T (2001). "Identification of a PDZ domain containing Golgi protein, GOPC, as an interaction partner of frizzled". Biochem. Biophys. Res. Commun. 286 (4): 771–8. doi:10.1006/bbrc.2001.5430. PMID 11520064. CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241 Freely accessible. PMID 12477932. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Weidler C, Schaumburger J, Miller LE; et al. (2004). "Synovial density of frizzled 5-positive cells does not differ between patients with RA and OA and is independent of inflammation". J. Rheumatol. 31 (9): 1874–5. PMID 15338479. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Omoto S, Hayashi T, Kitahara K; et al. (2004). "Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R)". Ophthalmic Genet. 25 (2): 81–90. doi:10.1080/13816810490514270. PMID 15370539. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Holmen SL, Robertson SA, Zylstra CR, Williams BO (2005). "Wnt-independent activation of beta-catenin mediated by a Dkk1-Fz5 fusion protein". Biochem. Biophys. Res. Commun. 328 (2): 533–9. doi:10.1016/j.bbrc.2005.01.009. PMID 15694380. CS1 maint: Multiple names: authors list (link)
• Hillier LW, Graves TA, Fulton RS; et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Blumenthal A, Ehlers S, Lauber J; et al. (2006). "The Wingless homolog WNT5A and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation". Blood. 108 (3): 965–73. doi:10.1182/blood-2005-12-5046. PMID 16601243. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yamamoto H, Komekado H, Kikuchi A (2006). "Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of beta-catenin". Dev. Cell. 11 (2): 213–23. doi:10.1016/j.devcel.2006.07.003. PMID 16890161. CS1 maint: Multiple names: authors list (link)
• Katoh Y, Katoh M (2007). "Conserved POU-binding site linked to SP1-binding site within FZD5 promoter: Transcriptional mechanisms of FZD5 in undifferentiated human ES cells, fetal liver/spleen, adult colon, pancreatic islet, and diffuse-type gastric cancer". Int. J. Oncol. 30 (3): 751–5. PMID 17273778. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.