FZD10

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Frizzled homolog 10 (Drosophila)
Identifiers
Symbols	FZD10; FZ-10; FzE7; hFz10
External IDs	OMIM: 606147 MGI: 2136761 HomoloGene: 21411 IUPHAR: FZD10 GeneCards: FZD10 Gene
Gene Ontology Molecular function • receptor activity • non-G-protein coupled 7TM receptor activity • G-protein coupled receptor activity • Wnt receptor activity Cellular component • integral to plasma membrane • membrane Biological process • G-protein coupled receptor protein signaling pathway • Wnt receptor signaling pathway • multicellular organismal development Sources: Amigo / EGO
RNA expression pattern
250px
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	11211	93897
Ensembl	ENSG00000111432	n/a
UniProt	Q9ULW2	n/a
RefSeq (mRNA)	NM_007197	XM_974070
RefSeq (protein)	NP_009128	XP_979164
Location (UCSC)	Chr 12: 129.21 - 129.22 Mb	n/a
PubMed search	[1]	[2]

Frizzled-10 is a protein that in humans is encoded by the FZD10 gene. FZD10 has also been designated as CD350 (cluster of differentiation 350).

This gene is a member of the frizzled gene family. Members of this family encode 7-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. Using array analysis, expression of this intronless gene is significantly up-regulated in two cases of primary colon cancer.

See also

• Frizzled

Further reading

• Finch PW, He X, Kelley MJ; et al. (1997). "Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action". Proc. Natl. Acad. Sci. U.S.A. 94 (13): 6770–5. doi:10.1073/pnas.94.13.6770. PMC 21233 Freely accessible. PMID 9192640. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tanaka S, Akiyoshi T, Mori M; et al. (1998). "A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals". Proc. Natl. Acad. Sci. U.S.A. 95 (17): 10164–9. doi:10.1073/pnas.95.17.10164. PMC 21479 Freely accessible. PMID 9707618. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kumar S, Connor JR, Dodds RA; et al. (2001). "Identification and initial characterization of 5000 expressed sequenced tags (ESTs) each from adult human normal and osteoarthritic cartilage cDNA libraries". Osteoarthr. Cartil. 9 (7): 641–53. doi:10.1053/joca.2001.0421. PMID 11597177. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Terasaki H, Saitoh T, Shiokawa K, Katoh M (2002). "Frizzled-10, up-regulated in primary colorectal cancer, is a positive regulator of the WNT - beta-catenin - TCF signaling pathway". Int. J. Mol. Med. 9 (2): 107–12. PMID 11786918. CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241 Freely accessible. PMID 12477932. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Omoto S, Hayashi T, Kitahara K; et al. (2004). "Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R)". Ophthalmic Genet. 25 (2): 81–90. doi:10.1080/13816810490514270. PMID 15370539. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 Freely accessible. PMID 15489334. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

External links

• "Frizzled Receptors: FZD₁₀". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 
• MeSH FZD10+protein,+human

This article incorporates text from the United States National Library of Medicine, which is in the public domain.