Pyroglutamylated RFamide peptide receptor

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pyroglutamylated RFamide peptide receptor
Identifiers
Symbols	QRFPR; GPR103 ; AQ27; MGC149217; SP9155
External IDs	OMIM: 606925 MGI: 2677633 HomoloGene: 18865 IUPHAR: QRFP GeneCards: QRFPR Gene
Gene Ontology Molecular function • rhodopsin-like receptor activity • receptor activity • neuropeptide Y receptor activity Cellular component • membrane • integral to membrane Biological process • signal transduction • G-protein coupled receptor protein signaling pathway Sources: Amigo / EGO
Orthologs
Species	Human	Mouse
Entrez	84109	229214
Ensembl	ENSG00000186867	ENSMUSG00000058400
UniProt	Q96P65	Q3UQ27
RefSeq (mRNA)	NM_198179	NM_198192
RefSeq (protein)	NP_937822	NP_937835
Location (UCSC)	Chr 4: 122.47 - 122.52 Mb	Chr 3: 36.37 - 36.41 Mb
PubMed search	[1]	[2]

Pyroglutamylated RFamide peptide receptor also known as orexigenic neuropeptide QRFP receptor or G-protein coupled receptor 103 (GPR103) is a protein that in humans is encoded by the QRFPR gene.

Function

G protein-coupled receptors (GPCRs, or GPRs) contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.

A 26-amino acid RF-amide peptide, P518 functions as a high-affinity ligand of GPR103. Both GPR103 and P518 precursor mRNA exhibited highest expression in brain. The 43-amino acid QRFP peptide, a longer form of the P518 peptide is necessary to exhibit full agonistic activity with GPR103. Intravenous administration QRFP caused release of aldosterone, suggesting that QRFP and GPR103 regulate adrenal function.

Further reading

• Lee DK, Nguyen T, Lynch KR; et al. (2001). "Discovery and mapping of ten novel G protein-coupled receptor genes". Gene. 275 (1): 83–91. doi:10.1016/S0378-1119(01)00651-5. PMID 11574155. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jiang Y, Luo L, Gustafson EL; et al. (2003). "Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155". J. Biol. Chem. 278 (30): 27652–7. doi:10.1074/jbc.M302945200. PMID 12714592. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fukusumi S, Yoshida H, Fujii R; et al. (2004). "A new peptidic ligand and its receptor regulating adrenal function in rats". J. Biol. Chem. 278 (47): 46387–95. doi:10.1074/jbc.M305270200. PMID 12960173. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kimura K, Wakamatsu A, Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Takayasu S, Sakurai T, Iwasaki S; et al. (2006). "A neuropeptide ligand of the G protein-coupled receptor GPR103 regulates feeding, behavioral arousal, and blood pressure in mice". Proc. Natl. Acad. Sci. U.S.A. 103 (19): 7438–43. doi:10.1073/pnas.0602371103. PMID 16648250. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

External links

• "Peptide P518 Receptor". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.