GPR98

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G protein-coupled receptor 98
Identifiers
Symbols	GPR98; USH2B; DKFZp761P0710; FEB4; KIAA0686; MASS1; USH2C; VLGR1; VLGR1b
External IDs	OMIM: 602851 MGI: 1274784 HomoloGene: 19815 IUPHAR: GPR98 GeneCards: GPR98 Gene
Gene Ontology Molecular function • receptor activity • G-protein coupled receptor activity • calcium ion binding Cellular component • membrane • integral to membrane Biological process • cell communication • signal transduction • neuropeptide signaling pathway • nervous system development • visual perception • sensory perception of sound • cell-cell adhesion • response to stimulus Sources: Amigo / EGO
RNA expression pattern
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More reference expression data
Orthologs
Species	Human	Mouse
Entrez	84059	110789
Ensembl	ENSG00000164199	ENSMUSG00000069170
UniProt	Q8WXG9	Q8C1E5
RefSeq (mRNA)	NM_032119	NM_054053
RefSeq (protein)	NP_115495	NP_473394
Location (UCSC)	Chr 5: 89.95 - 90.5 Mb	Chr 13: 81.56 - 82.07 Mb
PubMed search	[1]	[2]

G protein-coupled receptor 98, also known as GPR98, is a human protein and gene.

This gene encodes a member of the G-protein coupled receptor superfamily. The protein binds calcium and is expressed in the central nervous system. It is also known as very large G-protein coupled receptor 1 because it is 6300 residues long. It contains a C-terminal 7-transmembrane receptor domain, whereas the large N-terminal segment (5900 residues) includes 35 calcium binding Calx-beta domains, and 6 EAR domains. Mutations in this gene are associated with Usher syndrome 2 and familial febrile seizures. Several alternatively spliced transcripts have been described.

External Links

• GeneReviews/NCBI/NIH/UW entry on Usher Syndrome Type II

Further reading

• Nakajima D, Okazaki N, Yamakawa H; et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Staub E, Pérez-Tur J, Siebert R; et al. (2002). "The novel EPTP repeat defines a superfamily of proteins implicated in epileptic disorders". Trends Biochem. Sci. 27 (9): 441–4. doi:10.1016/S0968-0004(02)02163-1. PMID 12217514. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ishikawa K, Nagase T, Suyama M; et al. (1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nakayama J, Hamano K, Iwasaki N; et al. (2000). "Significant evidence for linkage of febrile seizures to chromosome 5q14-q15". Hum. Mol. Genet. 9 (1): 87–91. doi:10.1093/hmg/9.1.87. PMID 10587582. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pieke-Dahl S, Möller CG, Kelley PM; et al. (2000). "Genetic heterogeneity of Usher syndrome type II: localisation to chromosome 5q". J. Med. Genet. 37 (4): 256–62. doi:10.1136/jmg.37.4.256. PMC 1734554 Freely accessible. PMID 10745043. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nikkila H, McMillan DR, Nunez BS; et al. (2001). "Sequence similarities between a novel putative G protein-coupled receptor and Na+/Ca2+ exchangers define a cation binding domain". Mol. Endocrinol. 14 (9): 1351–64. doi:10.1210/me.14.9.1351. PMID 10976914. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wiemann S, Weil B, Wellenreuther R; et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMC 311072 Freely accessible. PMID 11230166. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Skradski SL, Clark AM, Jiang H; et al. (2001). "A novel gene causing a mendelian audiogenic mouse epilepsy". Neuron. 31 (4): 537–44. doi:10.1016/S0896-6273(01)00397-X. PMID 11545713. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• McMillan DR, Kayes-Wandover KM, Richardson JA, White PC (2002). "Very large G protein-coupled receptor-1, the largest known cell surface protein, is highly expressed in the developing central nervous system". J. Biol. Chem. 277 (1): 785–92. doi:10.1074/jbc.M108929200. PMID 11606593. CS1 maint: Multiple names: authors list (link)
• Nagase T, Kikuno R, Ohara O (2002). "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins". DNA Res. 8 (6): 319–27. doi:10.1093/dnares/8.6.319. PMID 11853319. CS1 maint: Multiple names: authors list (link)
• Nakayama J, Fu YH, Clark AM; et al. (2002). "A nonsense mutation of the MASS1 gene in a family with febrile and afebrile seizures". Ann. Neurol. 52 (5): 654–7. doi:10.1002/ana.10347. PMID 12402266. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241 Freely accessible. PMID 12477932. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Weston MD, Luijendijk MW, Humphrey KD; et al. (2004). "Mutations in the VLGR1 gene implicate G-protein signaling in the pathogenesis of Usher syndrome type II". Am. J. Hum. Genet. 74 (2): 357–66. doi:10.1086/381685. PMC 1181933 Freely accessible. PMID 14740321. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bjarnadóttir TK, Fredriksson R, Höglund PJ; et al. (2005). "The human and mouse repertoire of the adhesion family of G-protein-coupled receptors". Genomics. 84 (1): 23–33. doi:10.1016/j.ygeno.2003.12.004. PMID 15203201. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fu GK, Wang JT, Yang J; et al. (2005). "Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes". Genomics. 84 (1): 205–10. doi:10.1016/j.ygeno.2004.01.011. PMID 15203218. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Schwartz SB, Aleman TS, Cideciyan AV; et al. (2005). "Disease expression in Usher syndrome caused by VLGR1 gene mutation (USH2C) and comparison with USH2A phenotype". Invest. Ophthalmol. Vis. Sci. 46 (2): 734–43. doi:10.1167/iovs.04-1136. PMID 15671307. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kimura K, Wakamatsu A, Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129 Freely accessible. PMID 16344560. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)