GPR81

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G protein-coupled receptor 81
Identifiers
Symbols	GPR81; FKSG80; GPR104; TA-GPCR
External IDs	OMIM: 606923 MGI: 2441671 HomoloGene: 13060 IUPHAR: GPR81 (temporary name) GeneCards: GPR81 Gene
Gene Ontology Molecular function • rhodopsin-like receptor activity • receptor activity Cellular component • membrane • integral to membrane Biological process • signal transduction • G-protein coupled receptor protein signaling pathway Sources: Amigo / EGO
RNA expression pattern
250px
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	27198	243270
Ensembl	ENSG00000196917	ENSMUSG00000049241
UniProt	Q9BXC0	Q8C131
RefSeq (mRNA)	NM_032554	NM_175520
RefSeq (protein)	NP_115943	NP_780729
Location (UCSC)	Chr 12: 121.78 - 121.78 Mb	Chr 5: 124.14 - 124.14 Mb
PubMed search	[1]	[2]

G protein-coupled receptor 81, also known as GPR81, is a protein that in humans is encoded by the GPR81 gene.

G protein-coupled receptors (GPCRs, or GPRs), such as GPR81, contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.

Lactate activates the GPR81 receptor which in turn inhibits lipolysis in fat cells.

Further reading

• Takeda S, Kadowaki S, Haga T; et al. (2002). "Identification of G protein-coupled receptor genes from the human genome sequence". FEBS Lett. 520 (1-3): 97–101. doi:10.1016/S0014-5793(02)02775-8. PMID 12044878. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241 Freely accessible. PMID 12477932. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mao M, Biery MC, Kobayashi SV; et al. (2005). "T lymphocyte activation gene identification by coregulated expression on DNA microarrays". Genomics. 83 (6): 989–99. doi:10.1016/j.ygeno.2003.12.019. PMID 15177553. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 Freely accessible. PMID 15489334. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)