GPR3

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G protein-coupled receptor 3
Identifiers
Symbols	GPR3; ACCA
External IDs	OMIM: 600241 MGI: 101908 HomoloGene: 31303 IUPHAR: GPR3 GeneCards: GPR3 Gene
Gene Ontology Molecular function • rhodopsin-like receptor activity • receptor activity Cellular component • integral to plasma membrane • membrane Biological process • signal transduction • G-protein coupled receptor protein signaling pathway • G-protein signaling, adenylate cyclase activating pathway Sources: Amigo / EGO
RNA expression pattern
250px
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2827	14748
Ensembl	ENSG00000181773	ENSMUSG00000049649
UniProt	P46089	Q3USD4
RefSeq (mRNA)	NM_005281	NM_008154
RefSeq (protein)	NP_005272	NP_032180
Location (UCSC)	Chr 1: 27.59 - 27.59 Mb	Chr 4: 132.48 - 132.48 Mb
PubMed search	[1]	[2]

G-protein coupled receptor 3 is a protein that in humans is encoded by the GPR3 gene. The protein encoded by this gene is a member of the G protein-coupled receptor family of transmembrane receptors and is involved in signal transduction.

Function

GPR3 activates adenylate cyclase in the absence of ligand. GPR3 is expressed in mammalian oocytes where it maintains meiotic arrest and is thought to be a communication link between oocytes and the surrounding somatic tissue. While GPR3 have a certain level of constitutive activity, it is believed that sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine (SPC) are ligands that further activate the receptor.

Further reading

• Eggerickx D, Denef JF, Labbe O; et al. (1995). "Molecular cloning of an orphan G-protein-coupled receptor that constitutively activates adenylate cyclase". Biochem. J. 309 ( Pt 3): 837–43. PMC 1135708 Freely accessible. PMID 7639700. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Iismaa TP, Kiefer J, Liu ML; et al. (1995). "Isolation and chromosomal localization of a novel human G-protein-coupled receptor (GPR3) expressed predominantly in the central nervous system". Genomics. 24 (2): 391–4. doi:10.1006/geno.1994.1635. PMID 7698767. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Heiber M, Docherty JM, Shah G; et al. (1995). "Isolation of three novel human genes encoding G protein-coupled receptors". DNA Cell Biol. 14 (1): 25–35. doi:10.1089/dna.1995.14.25. PMID 7832990. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Song ZH, Modi W, Bonner TI (1996). "Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors". Genomics. 28 (2): 347–9. doi:10.1006/geno.1995.1154. PMID 8530049. CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241 Freely accessible. PMID 12477932. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Uhlenbrock K, Huber J, Ardati A; et al. (2003). "Fluid shear stress differentially regulates gpr3, gpr6, and gpr12 expression in human umbilical vein endothelial cells". Cell. Physiol. Biochem. 13 (2): 75–84. doi:10.1159/000070251. PMID 12649592. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 Freely accessible. PMID 15489334. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gregory SG, Barlow KF, McLay KE; et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)