Corticotropin releasing hormone receptor 2

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Corticotropin releasing hormone receptor 2
Identifiers
Symbols	CRHR2; CRFR2
External IDs	OMIM: 602034 MGI: 894312 HomoloGene: 55612 IUPHAR: CRF2 GeneCards: CRHR2 Gene
Gene Ontology Molecular function • receptor activity • G-protein coupled receptor activity • corticotrophin-releasing factor receptor activity Cellular component • plasma membrane • integral to plasma membrane Biological process • signal transduction • G-protein coupled receptor protein signaling pathway • G-protein signaling, coupled to cAMP nucleotide second messenger Sources: Amigo / EGO
RNA expression pattern
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More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1395	12922
Ensembl	ENSG00000106113	ENSMUSG00000003476
UniProt	Q13324	Q3UQP0
RefSeq (mRNA)	NM_001883	NM_009953
RefSeq (protein)	NP_001874	NP_034083
Location (UCSC)	Chr 7: 30.66 - 30.71 Mb	Chr 6: 55.02 - 55.06 Mb
PubMed search	[1]	[2]

Corticotropin releasing hormone receptor 2 (CRHR2) is a human protein, also known as CRF₂, with CRF₂ now being the IUPHAR-recommended name.

See also

• Corticotropin releasing hormone receptor

Further reading

• Perrin MH, Donaldson CJ, Chen R; et al. (1994). "Cloning and functional expression of a rat brain corticotropin releasing factor (CRF) receptor". Endocrinology. 133 (6): 3058–61. doi:10.1210/en.133.6.3058. PMID 8243338. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Liaw CW, Lovenberg TW, Barry G; et al. (1996). "Cloning and characterization of the human corticotropin-releasing factor-2 receptor complementary deoxyribonucleic acid". Endocrinology. 137 (1): 72–7. doi:10.1210/en.137.1.72. PMID 8536644. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Donaldson CJ, Sutton SW, Perrin MH; et al. (1996). "Cloning and characterization of human urocortin". Endocrinology. 137 (5): 2167–70. doi:10.1210/en.137.5.2167. PMID 8612563. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Meyer AH, Ullmer C, Schmuck K; et al. (1997). "Localization of the human CRF2 receptor to 7p21-p15 by radiation hybrid mapping and FISH analysis". Genomics. 40 (1): 189–90. doi:10.1006/geno.1996.4521. PMID 9070940. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Valdenaire O, Giller T, Breu V; et al. (1997). "A new functional isoform of the human CRF2 receptor for corticotropin-releasing factor". Biochim. Biophys. Acta. 1352 (2): 129–32. PMID 9199241. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gottowik J, Goetschy V, Henriot S; et al. (1998). "Labelling of CRF1 and CRF2 receptors using the novel radioligand, [3H]-urocortin". Neuropharmacology. 36 (10): 1439–46. doi:10.1016/S0028-3908(97)00098-1. PMID 9423932. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kostich WA, Chen A, Sperle K, Largent BL (1998). "Molecular identification and analysis of a novel human corticotropin-releasing factor (CRF) receptor: the CRF2gamma receptor". Mol. Endocrinol. 12 (8): 1077–85. doi:10.1210/me.12.8.1077. PMID 9717834. CS1 maint: Multiple names: authors list (link)
• Willenberg HS, Bornstein SR, Hiroi N; et al. (2000). "Effects of a novel corticotropin-releasing-hormone receptor type I antagonist on human adrenal function". Mol. Psychiatry. 5 (2): 137–41. doi:10.1038/sj.mp.4000720. PMID 10822340. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Reyes TM, Lewis K, Perrin MH; et al. (2001). "Urocortin II: a member of the corticotropin-releasing factor (CRF) neuropeptide family that is selectively bound by type 2 CRF receptors". Proc. Natl. Acad. Sci. U.S.A. 98 (5): 2843–8. doi:10.1073/pnas.051626398. PMC 30227 Freely accessible. PMID 11226328. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hsu SY, Hsueh AJ (2001). "Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor". Nat. Med. 7 (5): 605–11. doi:10.1038/87936. PMID 11329063. 
• Lewis K, Li C, Perrin MH; et al. (2001). "Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor". Proc. Natl. Acad. Sci. U.S.A. 98 (13): 7570–5. doi:10.1073/pnas.121165198. PMC 34709 Freely accessible. PMID 11416224. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241 Freely accessible. PMID 12477932. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Scherer SW, Cheung J, MacDonald JR; et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961 Freely accessible. PMID 12690205. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wetzka B, Sehringer B, Schäfer WR; et al. (2004). "Expression patterns of CRH, CRH receptors, and CRH binding protein in human gestational tissue at term". Exp. Clin. Endocrinol. Diabetes. 111 (3): 154–61. doi:10.1055/s-2003-39778. PMID 12784189. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hillier LW, Fulton RS, Fulton LA; et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Karteris E, Hillhouse EW, Grammatopoulos D (2004). "Urocortin II is expressed in human pregnant myometrial cells and regulates myosin light chain phosphorylation: potential role of the type-2 corticotropin-releasing hormone receptor in the control of myometrial contractility". Endocrinology. 145 (2): 890–900. doi:10.1210/en.2003-1210. PMID 14592950. CS1 maint: Multiple names: authors list (link)
• Seres J, Bornstein SR, Seres P; et al. (2004). "Corticotropin-releasing hormone system in human adipose tissue". J. Clin. Endocrinol. Metab. 89 (2): 965–70. doi:10.1210/jc.2003-031299. PMID 14764822. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Brandenberger R, Wei H, Zhang S; et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nanda SA, Roseboom PH, Nash GA; et al. (2004). "Characterization of the human corticotropin-releasing factor2(a) receptor promoter: regulation by glucocorticoids and the cyclic adenosine 5'-monophosphate pathway". Endocrinology. 145 (12): 5605–15. doi:10.1210/en.2004-0907. PMID 15331578. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 Freely accessible. PMID 15489334. CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

External links

• "Corticotropin-releasing Factor Receptors: CRF₂". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 
• MeSH Corticotropin-releasing+hormone+receptors

This article incorporates text from the United States National Library of Medicine, which is in the public domain.